Trends in Cancer and Pulmonary Embolism-related mortality in the adult U.S. population: A CDC WONDER database analysis from 1999 to 2020

Obieda Altobaishat; Basma Ehab Amer; Ahmed Farid Gadelmawla; Amna Nadeem; Yehya Khlidj; Hashim Almasri; Mustafa Turkmani; Mohamed Abouzid

doi:10.20883/medical.e1396

Authors

Obieda Altobaishat Jordan University of Science and Technology https://orcid.org/0000-0001-7213-0507
Basma Ehab Amer Benha University
Ahmed Farid Gadelmawla Menoufia University , Medical Research Group of Egypt, Negida Academy, Arlington, USA
Amna Nadeem University of Faisalabad
Yehya Khlidj University of Algiers Benyoucef Benkhedda https://orcid.org/0000-0002-3448-9946
Hashim Almasri Jordan University of Science and Technology
Mustafa Turkmani Michigan State University , McLaren Health Care
Mohamed Abouzid Poznan University of Medical Sciences

DOI:

https://doi.org/10.20883/medical.e1396

Keywords:

neoplasm, malignancy, cancer, CDC, pulmonary embolism

Abstract

Introduction. Cancer and pulmonary embolism (PE) remain significant global health challenges, with approximately 20 million new cancer cases diagnosed worldwide, resulting in 9.7 million deaths. We aimed to assess trends in PE-associated mortality among U.S. cancer patients (1999–2020).
Material and methods. CDC WONDER death certificate data identified 179,044 PE-associated deaths in cancer patients (age ≥25). Age-adjusted mortality rates (AAMRs) per 100,000 were obtained, stratified by year, sex, race/ethnicity, region, and cancer type, with 95% confidence intervals. Joinpoint regression identified trends.
Results. A total of 179,044 PE-associated deaths in U.S. adults with cancer were recorded from 1999 to 2020, with AAMRs rising during this period. Overall, men had higher AAMRs than women (4.2, 95% CI: 4.0–4.3 vs 3.4, 95% CI: 3.3–3.5). AAMRs were highest among NH Black/African Americans (5.7, 95% CI: 5.7–5.8); the largest absolute number of deaths occurred in Whites, and the fewest in American Indians/Alaska Natives. Most deaths (64%) occurred in medical facilities. Among cancer types, lung cancer showed the highest mortality (AAMR 1.0, 95% CI: 0.97–1.05), whereas prostate cancer had the lowest (AAMR 0.20, 95% CI: 0.20–0.21).
Conclusions. PE-associated mortality in cancer patients rose from 1999 to 2020, disproportionately affecting men, NH Black/African Americans, Midwest residents, and lung cancer patients.

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Author Biographies

Obieda Altobaishat, Jordan University of Science and Technology

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Basma Ehab Amer, Benha University

Faculty of Medicine, Benha University, Benha, Egypt
Ahmed Farid Gadelmawla, Menoufia University, Medical Research Group of Egypt, Negida Academy, Arlington, USA

Faculty of Medicine, Menoufia University, Menoufia, Egypt
Medical Research Group of Egypt, Negida Academy, Arlington, USA
Amna Nadeem, University of Faisalabad

Faculty of Medicine, Faisalabad Medical University, Faisalabad, Pakistan
Yehya Khlidj, University of Algiers Benyoucef Benkhedda

Faculty of Medicine, University of Algiers Benyoucef Benkhedda, Algiers, Algeria
Hashim Almasri, Jordan University of Science and Technology

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Mustafa Turkmani, Michigan State University, McLaren Health Care

Michigan State University, Faculty of Medicine, East Lansing, Michigan, USA
McLaren Health Care, Oakland, Michigan, USA
Mohamed Abouzid, Poznan University of Medical Sciences

Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznań, Poland

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