Violation of the regulation of cytokine in chronic catarrhal gingivitis in overweight children
Keywords:cytokine, chronic catarrhal gingivitis, overweight children, oral fluid
AbstractIntroduction. The development of inflammation in the periodontium is inextricably linked to the system processes in the organism, including an accompanying pathology, which is often parallel. The WHO particularly emphasizes the dissemination of overweight among children. Against the background of excessive weight gain in children there are the series metabolic disorders that provoke chronic diseases, including chronic catarrhal gingivitis.
Aim. The aim of this study was to identify the dynamics of cytokines (IL-4, IL-6) in oral fluid and characterize the immune system of the oral cavity in children with overweight and obesity.
Material and Methods. This study presents the results of examination of 80 children with overweight and obese patients with chronic catarrhal gingivitis (CCG), aged 12–15 years. Based on anthropometric surveys body mass index (BMI) was calculated. Also the obtained measurements and calculations were evaluated by percentile tables that were designed by the WHO in 2007 for children and adolescents 5 to 19 years for both sexes separately (WHO, 2007). The content of interleukin (IL-4; IL-6) in oral fluid in children was determined by using kits of reagents of company "Vector-Best" (Russia), based on solid-phase "sandwich" variant of immunoenzyme analysis.
Results. The level of IL-4 in the oral fluid of children with chronic catarrhal gingivitis decreases (1.8 times) with increasing of age and with the deepening of violations of fat metabolism. The level of IL-6 in the oral fluid of children with chronic catarrhal gingivitis increases (2.9 times) with increasing of age and the presence of excess body weight and obesity.
Conclusions. Further study of interleukin imbalance in the oral fluid of patients with chronic catarrhal gingivitis and overweight is a promising area of research to develop methods of prevention and pathogenic therapy.
Abaturov ?E Peculiarities of the metabolic syndrome in children. Pediatrician. 2011;4:54–61.
?ntonova IN, Levyn MY, ?osova ?V. The regulatory role of cytokines in the development of inflammation in the acute phase of a chronic catarrhal gingivitis in athletes. Cytokines and inflammation. 2014;4:56–60.
Dixon AE. Obesity: changing asthma in the 21st century. Am J Respir Crit Care Med. 2012;186(5):395–396.
Kaskova LF, ?bramova OE. The prevalence of chronic catarrhal gingivitis in children in Poltava. Ukrainian Dental Almanac. 2002;(2):51–53.
Khomenko LA, Bidenko NV, Ostapko EI. Periodontal disease in young adults: problem of risk and diagnosis. Dentistry. 2006;1–2:54–58.
Modena TN, Mamayeva EV, Lopatkina ?I. Pathology of periodontal tissues and the functional state of the organism in adolescents. Pediatric Dentistry and Prevention. 2006;1–2:78–84.
Pischon, N, Heng N, Bernimoulin JP, Kleber BM, Willich SN, Pischon T. Obesity, inflammation, and periodontal disease. J Dent Res. 2007;5:400–409.
Pobedynnaya GP, Yartseva SV. On the issue of comorbid diseases: asthma and obesity. Asthma and allergy. 2014;2:54–61.
Prystupa LN, Opimakh OI. The role of leptin in the pathogenesis of osteoarthritis in obesity. Ukrainian Journal of Rheumatology. 2010;3:64–67.
Shilina NM, Lashenkova EA, Surkov AG. The study of the spectrum of leukotrienes in children with obesity. Abstracts of XI All-Russian Congress of Dietitians and Nutritionists "Nutrition and Health", Moscow; 2009. p. 184.
Volkova MN, Yanchenko VV. The study of interleukin 1ß, interferon ?, interleukin-2 in oral fluid of patients with chronic generalized periodontitis, gingivitis and periodontally healthy patients. Cytokines and inflammation. 2011;4(10):46–51.
[Internet] World Health Organization (2007). BMI-for-age (5–19 years). Available at: www.who.int/growthref/who2007_bmi_for_age/en.
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