Genetic background of Meniere’s disease
DOI:
https://doi.org/10.20883/jms.2018.289Keywords:
Meniere’s disease, genetic background, gene identificationAbstract
Meniere’s disease (MD) as an inner ear disorder including such symptoms as recurrent vertigo attacks, tinnitus, fluctuating or progressive sensorineural hearing loss. Its relatively frequent familial incidence implicates a genetic background. An autosomal dominant inheritance was commonly observed with a few exceptions. It was established that Meniere’s disease is not a monogenic disorder. Instead a group of genes of genomic and mitochondrial genes was established as determinants of hearing loss. Another group of genes was associated with inner ear (vestibulum, labyrinth, endolymph) alterations followed by dizziness and tinnitus. Altogether, many studies suggest a multigenic interaction to predispose to develop Meniere’s disease.Downloads
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Copyright (c) 2018 Krzysztof Szyfter, Wojciech Gawęcki, Witold Szyfter
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Accepted 2018-09-28
Published 2018-09-30
