Some nitroimidazole derivatives as antibacterial and antifungal agents in in vitro study

Justyna Żwawiak; Dorota Olender; Lucjusz Zaprutko

doi:10.20883/jms.218

Authors

Justyna Żwawiak Chair and Department of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0002-5420-6499
Dorota Olender Chair and Department of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0001-8320-5201
Lucjusz Zaprutko Chair and Department of Organic Chemistry, Pharmaceutical Faculty, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0003-1121-6272

DOI:

https://doi.org/10.20883/jms.218

Keywords:

nitroimidazoles, nitroimidazooxazoles, nitroimidazotetrahydropyrimidines, M. tuberculosis, antifungals

Abstract

Nitroimidazoles have wide range of therapeutic uses mainly as anaerobic antibacterials and antiprotozoal agents. Some bicyclic nitroimidazodihydrooxazoles and nitroimidazotetrahydrooxazines are found to be antituberculosis agents. Hence, the biological and chemical properties of mentioned substances are of great interest to scientists. The aim of this review is to show the general knowledge concerning the chemistry and biological activity of some nitroimidazole derivatives, based on experimental studies. The results of biological tests provide many useful information on the effects of particular groups or other structural elements on the level of pharmacological activity. Also, these studies can be helpful in further planning of syntheses of active substances with using nitroimidazole moiety.

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