Pandemic potential of henipaviruses

Authors

  • Aleksandra Wojtkiewicz Faculty of Veterinary Medicine, Nicolaus Copernicus University in Toruń, Poland https://orcid.org/0009-0003-7926-8025
  • Maciej Szota Department of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland https://orcid.org/0000-0001-6611-675X
  • Kornelia Kędziora–Kornatowska Department of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń Bydgoszcz, Nicolaus Copernicus University in Toruń https://orcid.org/0000-0003-4777-5252

DOI:

https://doi.org/10.20883/medical.e929

Keywords:

pandemic potential, Hendra virus, Nipah virus, epizootics, public health

Abstract

Introduction and purpose. Hendra and Nipah are two highly dangerous zoonotic viruses belonging to the group of henipaviruses. Although they have been known for over 20 years, no human drug or vaccine has been invented. This paper aims to to describe the epidemiology of the reported paramyxoviruses, the pandemic potential of henipaviruses, and a standardised action plan to counter their spread. This paper reviews scientific articles from 2012-2023 published in scientific databases such as Pubmed, Researchgate, and Google Scholar. The keywords used were pandemic potential of henipaviruses, Hendra virus, Nipah virus, and henipavirus epidemics.

State of knowledge description. The mortality rate of henipaviruses varies between 50 and 100%. The Nipah virus is particularly dangerous, with epidemics recurring virtually every year in Asia since 1998. The Hendra virus situation may be manageable because there is an effective vaccine for horses most vulnerable to infection. Due to human activity, the habitats and climate of the animals serving as virus reservoirs are changing. Because of frequent henipavirus outbreaks in Asia and Australia, extensive efforts are being made to contain and neutralise them rapidly..

Conclusions. As henipaviruses pose a high pandemic threat, more research into drugs and vaccines is required. It is also essential to develop effective bio-assurance plans, introduce controls on their operation and educate the population on the issue. Reservoir animals, through anthropogenic environmental changes, are changing habitats and feeding sites, making more and more territories vulnerable to the disease. New species of henipaviruses constantly emerge and pose an epizootic challenge to public health. Hence, an essential action is to increase the amount of research into the virus's epidemic development and conduct it as widely as possible.

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References

Ang BSP, Lim TCC, Wang L. Nipah Virus Infection. J Clin Microbiol. 2018 May 25;56(6):e01875-17. doi: 10.1128/JCM.01875-17. PMID: 29643201; PMCID: PMC5971524. DOI: https://doi.org/10.1128/JCM.01875-17

DeBuysscher BL, de Wit E, Munster VJ, Scott D, Feldmann H, Prescott J. Comparison of the pathogenicity of Nipah virus isolates from Bangladesh and Malaysia in the Syrian hamster. PLoS Negl Trop Dis. 2013;7(1):e2024. doi: 10.1371/journal.pntd.0002024. Epub 2013 Jan 17. PMID: 23342177; PMCID: PMC3547834. DOI: https://doi.org/10.1371/journal.pntd.0002024

Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT. Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review. Vet Q. 2019 Dec;39(1):26-55. doi: 10.1080/01652176.2019.1580827. PMID: 31006350; PMCID: PMC6830995. DOI: https://doi.org/10.1080/01652176.2019.1580827

Sharma V, Kaushik S, Kumar R, Yadav JP, Kaushik S. Emerging trends of Nipah virus: A review. Rev Med Virol. 2019 Jan;29(1):e2010. doi: 10.1002/rmv.2010. Epub 2018 Sep 24. PMID: 30251294; PMCID: PMC7169151. DOI: https://doi.org/10.1002/rmv.2010

Clayton BA. Nipah virus: transmission of a zoonotic paramyxovirus. Curr Opin Virol. 2017 Feb;22:97-104. doi: 10.1016/j.coviro.2016.12.003. Epub 2017 Jan 11. PMID: 28088124. DOI: https://doi.org/10.1016/j.coviro.2016.12.003

Islam MR, Dhar PS, Rahman MM. Newly outbreak of Nipah virus: epidemiology, symptoms, transmission, diagnostic testing, treatment, and global health concern. Int J Surg. 2023 Mar 1;109(3):507-508. doi: 10.1097/JS9.0000000000000050. PMID: 37093080; PMCID: PMC10389207. DOI: https://doi.org/10.1097/JS9.0000000000000050

Skowron K, Bauza-Kaszewska J, Grudlewska-Buda K, Wiktorczyk-Kapischke N, Zacharski M, Bernaciak Z, Gospodarek-Komkowska E. Nipah Virus-Another Threat From the World of Zoonotic Viruses. Front Microbiol. 2022 Jan 25;12:811157. doi: 10.3389/fmicb.2021.811157. PMID: 35145498; PMCID: PMC8821941. DOI: https://doi.org/10.3389/fmicb.2021.811157

Khusro A, Aarti C, Pliego AB, Cipriano-Salazar M. Hendra Virus Infection in Horses: A Review on Emerging Mystery Paramyxovirus. J Equine Vet Sci. 2020 Aug;91:103149. doi: 10.1016/j.jevs.2020.103149. Epub 2020 May 30. PMID: 32684248. DOI: https://doi.org/10.1016/j.jevs.2020.103149

Yuen KY, Fraser NS, Henning J, Halpin K, Gibson JS, Betzien L, Stewart AJ. Hendra virus: Epidemiology dynamics in relation to climate change, diagnostic tests and control measures. One Health. 2021 Jun;12:100207. doi: 10.1016/j.onehlt.2020.100207. Epub 2020 Dec 21. PMID: 33363250; PMCID: PMC7750128. DOI: https://doi.org/10.1016/j.onehlt.2020.100207

Li T, Liang Z, Huang W, Wang Y. Pseudotyped Virus for Henipavirus. Adv Exp Med Biol. 2023;1407:175-190. doi: 10.1007/978-981-99-0113-5_9. PMID: 36920697. DOI: https://doi.org/10.1007/978-981-99-0113-5_9

Dawes BE, Freiberg AN. Henipavirus infection of the central nervous system. Pathog Dis. 2019 Mar 1;77(2):ftz023. doi: 10.1093/femspd/ftz023. PMID: 30985897; PMCID: PMC6974701. DOI: https://doi.org/10.1093/femspd/ftz023

Quarleri J, Galvan V, Delpino MV. Henipaviruses: an expanding global public health concern? Geroscience. 2022 Oct;44(5):2447-2459. doi: 10.1007/s11357-022-00670-9. Epub 2022 Oct 11. PMID: 36219280; PMCID: PMC9550596.

Lawrence P, Escudero-Pérez B. Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models. Viruses. 2022 Apr 29;14(5):936. doi: 10.3390/v14050936. PMID: 35632678; PMCID: PMC9146692. DOI: https://doi.org/10.3390/v14050936

Broder CC, Weir DL, Reid PA. Hendra virus and Nipah virus animal vaccines. Vaccine. 2016 Jun 24;34(30):3525-34. doi: 10.1016/j.vaccine.2016.03.075. Epub 2016 May 4. PMID: 27154393; PMCID: PMC4933500. DOI: https://doi.org/10.1016/j.vaccine.2016.03.075

Amaya M, Broder CC. Vaccines to Emerging Viruses: Nipah and Hendra. Annu Rev Virol. 2020 Sep 29;7(1):447-473. doi: 10.1146/annurev-virology-021920-113833. PMID: 32991264; PMCID: PMC8782152. DOI: https://doi.org/10.1146/annurev-virology-021920-113833

Marsh GA, Wang LF. Hendra and Nipah viruses: why are they so deadly? Curr Opin Virol. 2012 Jun;2(3):242-7. doi: 10.1016/j.coviro.2012.03.006. Epub 2012 Apr 5. PMID: 22483665. DOI: https://doi.org/10.1016/j.coviro.2012.03.006

Satterfield BA, Dawes BE, Milligan GN. Status of vaccine research and development of vaccines for Nipah virus. Vaccine. 2016 Jun 3;34(26):2971-2975. doi: 10.1016/j.vaccine.2015.12.075. Epub 2016 Mar 11. PMID: 26973068. DOI: https://doi.org/10.1016/j.vaccine.2015.12.075

Gazal S, Sharma N, Gazal S, Tikoo M, Shikha D, Badroo GA, Rashid M, Lee SJ. Nipah and Hendra Viruses: Deadly Zoonotic Paramyxoviruses with the Potential to Cause the Next Pandemic. Pathogens. 2022 Nov 25;11(12):1419. doi: 10.3390/pathogens11121419. PMID: 36558753; PMCID: PMC9784551. DOI: https://doi.org/10.3390/pathogens11121419

Luby SP, Gurley ES. Epidemiology of henipavirus disease in humans. Curr Top Microbiol Immunol. 2012;359:25-40. doi: 10.1007/82_2012_207. PMID: 22752412. DOI: https://doi.org/10.1007/82_2012_207

Venkatesan A, Murphy OC. Viral Encephalitis. Neurol Clin. 2018 Nov;36(4):705-724. doi: 10.1016/j.ncl.2018.07.001. Epub 2018 Sep 20. PMID: 30366550. DOI: https://doi.org/10.1016/j.ncl.2018.07.001

Aditi, Shariff M. Nipah virus infection: A review. Epidemiol Infect. 2019 Jan;147:e95. doi: 10.1017/S0950268819000086. PMID: 30869046; PMCID: PMC6518547. DOI: https://doi.org/10.1017/S0950268819000086

Rathish B, Vaishnani K. Nipah Virus. 2023 Apr 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 34033338.

Sanchez S, Ly H. Langya henipavirus: Is it a potential cause for public health concern? Virulence. 2023 Dec;14(1):2154188. doi: 10.1080/21505594.2022.2154188. PMID: 36599832; PMCID: PMC9815250. DOI: https://doi.org/10.1080/21505594.2022.2154188

Soman Pillai V, Krishna G, Valiya Veettil M. Nipah Virus: Past Outbreaks and Future Containment. Viruses. 2020 Apr 20;12(4):465. doi: 10.3390/v12040465. PMID: 32325930; PMCID: PMC7232522.

Liew YJM, Ibrahim PAS, Ong HM, Chong CN, Tan CT, Schee JP, Gómez Román R, Cherian NG, Wong WF, Chang LY. The Immunobiology of Nipah Virus. Microorganisms. 2022 Jun 6;10(6):1162. doi: 10.3390/microorganisms10061162. PMID: 35744680; PMCID: PMC9228579. DOI: https://doi.org/10.3390/microorganisms10061162

Hanif M, Huang H, Sonkar V, Jaiswal V. The recent emergence of Langya henipavirus in China: Should we be concerned? Ann Med Surg (Lond). 2022 Nov 12;84:104896. doi: 10.1016/j.amsu.2022.104896. PMID: 36426096; PMCID: PMC9679479. DOI: https://doi.org/10.1016/j.amsu.2022.104896

Alam AM. Nipah virus, an emerging zoonotic disease causing fatal encephalitis. Clin Med (Lond). 2022 Jul;22(4):348-352. doi: 10.7861/clinmed.2022-0166. Epub 2022 Jun 27. PMID: 35760448; PMCID: PMC9345211. DOI: https://doi.org/10.7861/clinmed.2022-0166

Singhai M, Jain R, Jain S, Bala M, Singh S, Goyal R. Nipah Virus Disease: Recent Perspective and One Health Approach. Ann Glob Health. 2021 Oct 12;87(1):102. doi: 10.5334/aogh.3431. PMID: 34712599; PMCID: PMC8516003. DOI: https://doi.org/10.5334/aogh.3431

Weatherman S, Feldmann H, de Wit E. Transmission of henipaviruses. Curr Opin Virol. 2018 Feb;28:7-11. doi: 10.1016/j.coviro.2017.09.004. Epub 2017 Oct 14. PMID: 29035743; PMCID: PMC5835161. DOI: https://doi.org/10.1016/j.coviro.2017.09.004

Chakraborty S, Chandran D, Mohapatra RK, Islam MA, Alagawany M, Bhattacharya M, Chakraborty C, Dhama K. Langya virus, a newly identified Henipavirus in China - Zoonotic pathogen causing febrile illness in humans, and its health concerns: Current knowledge and counteracting strategies - Correspondence. Int J Surg. 2022 Sep;105:106882. doi: 10.1016/j.ijsu.2022.106882. Epub 2022 Sep 6. PMID: 36075552; PMCID: PMC9444302. DOI: https://doi.org/10.1016/j.ijsu.2022.106882

Raval RD, Mehta M. Nipah: An Interesting stance. Health Promot Perspect. 2020 Jan 28;10(1):5-7. doi: 10.15171/hpp.2020.03. PMID: 32104651; PMCID: PMC7036213. DOI: https://doi.org/10.15171/hpp.2020.03

Kummer S, Kranz DC. Henipaviruses-A constant threat to livestock and humans. PLoS Negl Trop Dis. 2022 Feb 18;16(2):e0010157. doi: 10.1371/journal.pntd.0010157. PMID: 35180217; PMCID: PMC8856525.

The Lancet. Nipah virus control needs more than R&D. Lancet. 2018 Jun 9;391(10137):2295. doi: 10.1016/S0140-6736(18)31264-9. PMID: 29900857. DOI: https://doi.org/10.1016/S0140-6736(18)31264-9

Quarleri J, Galvan V, Delpino MV. Henipaviruses: an expanding global public health concern? Geroscience. 2022 Oct;44(5):2447-2459. doi: 10.1007/s11357-022-00670-9. Epub 2022 Oct 11. PMID: 36219280; PMCID: PMC9550596. DOI: https://doi.org/10.1007/s11357-022-00670-9

Johnson K, Vu M, Freiberg AN. Recent advances in combating Nipah virus. Fac Rev. 2021 Sep 29;10:74. doi: 10.12703/r/10-74. PMID: 34632460; PMCID: PMC8483238. DOI: https://doi.org/10.12703/r/10-74

Gilkerson JR. Hendra virus: to vaccinate or not to vaccinate? What is the alternative? Aust Vet J. 2020 Dec;98(12):575-577. doi: 10.1111/avj.13028. PMID: 33258486 DOI: https://doi.org/10.1111/avj.13028

Gliński Z., Żmuda A., Risk factors for zoonoses emergence, Życie weterynaryje 2019,Faculty of Veterinary Medicine, University of Life Science in Lublin

Gliński Z., Żmuda A., Hendra – animal and human henipaviral disease with pandemic potential, Życie weterynaryjne 2023, Faculty of Veterinary Medicine, University of Life Sciences in Lublin

Kummer S, Kranz DC. Henipaviruses-A constant threat to livestock and humans. PLoS Negl Trop Dis. 2022 Feb 18;16(2):e0010157. doi: 10.1371/journal.pntd.0010157. PMID: 35180217; PMCID: PMC8856525 DOI: https://doi.org/10.1371/journal.pntd.0010157

Schemann K, Annand EJ, Reid PA, Lenz MF, Thomson PC, Dhand NK. Investigation of the effect of Equivac® HeV Hendra virus vaccination on Thoroughbred racing performance. Aust Vet J. 2018 Apr;96(4):132-141. doi: 10.1111/avj.12679. Epub 2018 Feb 4. PMID: 29399777. DOI: https://doi.org/10.1111/avj.12679

Thakur V, Thakur P, Ratho RK. Nipah Outbreak: Is it the beginning of another pandemic in the era of COVID-19 and Zika. Brain Behav Immun. 2022 Jan;99:25-26. doi: 10.1016/j.bbi.2021.09.015. Epub 2021 Sep 22. PMID: 34562598; PMCID: PMC8506197. DOI: https://doi.org/10.1016/j.bbi.2021.09.015

Soman Pillai V, Krishna G, Valiya Veettil M. Nipah Virus: Past Outbreaks and Future Containment. Viruses. 2020 Apr 20;12(4):465. doi: 10.3390/v12040465. PMID: 32325930; PMCID: PMC7232522. DOI: https://doi.org/10.3390/v12040465

Thiagarajan K. Nipah virus: India's Kerala state moves quickly to control fresh outbreak. BMJ. 2023 Sep 15;382:2117. doi: 10.1136/bmj.p2117. PMID: 37714528. DOI: https://doi.org/10.1136/bmj.p2117

https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON490#:~:text=Between%2012%20and%2015%20September%202023%2C%20a%20total,were%20reported%20within%20the%20Kozhikode%20district%20of%20Kerala.

Garbuglia AR, Lapa D, Pauciullo S, Raoul H, Pannetier D. Nipah Virus: An Overview of the Current Status of Diagnostics and Their Role in Preparedness in Endemic Countries. Viruses. 2023 Oct 7;15(10):2062. doi: 10.3390/v15102062. PMID: 37896839; PMCID: PMC10612039. DOI: https://doi.org/10.3390/v15102062

Orosco FL. Advancing the frontiers: Revolutionary control and prevention paradigms against Nipah virus. Open Vet J. 2023 Sep;13(9):1056-1070. doi: 10.5455/OVJ.2023.v13.i9.1. Epub 2023 Sep 30. PMID: 37842102; PMCID: PMC10576574. DOI: https://doi.org/10.5455/OVJ.2023.v13.i9.1

Mazzola LT, Kelly-Cirino C. Diagnostics for Nipah virus: a zoonotic pathogen endemic to Southeast Asia. BMJ Glob Health. 2019 Feb 1;4(Suppl 2):e001118. doi: 10.1136/bmjgh-2018-001118. PMID: 30815286; PMCID: PMC6361328. DOI: https://doi.org/10.1136/bmjgh-2018-001118

Churchil Livingstone. Virology, 2012, Pages 80-83. Chapter Paromyxoviruses; Stephen NJ., Korsman MMed FCPath DOI: https://doi.org/10.1016/B978-0-443-07367-0.00033-1

Akçali A. Biyolojik silah olarak viruslar [Viruses as biological weapons]. Mikrobiyol Bul. 2005 Jul;39(3):383-97. Turkish. PMID: 16358499.

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Published

2023-12-07

How to Cite

1.
Wojtkiewicz A, Szota M, Kędziora–Kornatowska K. Pandemic potential of henipaviruses. JMS [Internet]. 2023 Dec. 7 [cited 2024 Jun. 16];93(1):e929. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/929

Issue

Section

Review Papers
Received 2023-09-13
Accepted 2023-12-03
Published 2023-12-07