Future Opportunities in the Field of Drug Delivery Research
DOI:
https://doi.org/10.20883/medical.e925Keywords:
drug delivery, infectious disease, fungal infection, burn injury, organometallic antibiotics, peptide drugs, electrospun fiber mats, tyrosine-based polymersAbstract
Much of the priorities in drug delivery research are focused on targeted drug delivery for cancer therapies and a wide range of controlled drug release systems for commonly used active pharmaceutical ingredients (APIs). In this “thousand words article” we highlight some of the emerging health threats and future opportunities for drug delivery research.
Important emerging health threats include viral pandemics beyond COVID, antibiotic-resistant pathogens, the need for new antifungal therapies, and emerging diseases caused by increasing pollution and climate change. Fundamentally new drugs may be needed. For example, one little known research effort focuses on the development of new antibiotics based on metal-organic frameworks. Finally, new delivery approaches will be needed. This is illustrated by the development of a topical peptide delivery system as a wound dressing for burn patients, combining biotechnology (a new peptide) with polymer science (a new topical delivery system) to address a medical need (burn injury) for which there is currently no effective treatment. Another important trend is the shift in our collective understanding of impact, moving away from “counting papers” to considering the societal benefit of the research including its potential for commercialization. To remain relevant in the coming decade, we need to anticipate and embrace future challenges. This is particularly important for younger scientists.
Downloads
References
Ren H, Jia W, Xie Y, Yu M, Chen Y. Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chem Soc Rev. 2023 Jul 31;52(15):5172–254. DOI: https://doi.org/10.1039/D2CS00848C
Kassem AA. Nanotechnology Inspired Advanced Engineering Fundamentals for Optimizing Drug Delivery. Curr Drug Targets. 2018;19(15):1839–54. DOI: https://doi.org/10.2174/1389450119666180207092831
Schito GC, Debbia EA, Marchese A. The evolving threat of antibiotic resistance in Europe: new data from the Alexander Project. J Antimicrob Chemother. 2000 Jul;46 Suppl T1:3–9. DOI: https://doi.org/10.1093/oxfordjournals.jac.a020891
Fouladkhah AC, Thompson B, Camp JS. The Threat of Antibiotic Resistance in Changing Climate. Microorganisms [Internet]. 2020 May 16;8(5). Available from: http://dx.doi.org/10.3390/microorganisms8050748 DOI: https://doi.org/10.3390/microorganisms8050748
Lansdown ABG. Silver in Healthcare: Its Antimicrobial Efficacy and Safety in Use. Royal Society of Chemistry; 2010. 261 p.
Sekhon BS. Iodine: A support against infections and emerging as an antibiotic. Journal of Pharmaceutical Education & Research [Internet]. 2012;3(1). Available from: https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=09768173&asa=Y&AN=77554346&h=4GATUigcennnG%2Bt8TexQ6QFzbtUu6W0fGlPImPpsWSTNZMlNKjR%2FVn9z8w9qW4XEoYIcGV%2B4GCPmHve4yJIZAA%3D%3D&crl=c
Jaros SW, Król J, Bażanów B, Poradowski D, Chrószcz A, Nesterov DS, et al. Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid. Molecules [Internet]. 2020 May 1;25(9). Available from: http://dx.doi.org/10.3390/molecules25092119 DOI: https://doi.org/10.3390/molecules25092119
Jaros SW, Krogul-Sobczak A, Bażanów B, Florek M, Poradowski D, Nesterov DS, et al. Self-assembly and multifaceted bioactivity of a silver(I) quinolinate coordination polymer. Inorg Chem. 2021 Oct 18;60(20):15435–44. DOI: https://doi.org/10.1021/acs.inorgchem.1c02110
Impact of fungal diseases in the United States [Internet]. 2023 [cited 2023 Sep 4]. Available from: https://www.cdc.gov/fungal/cdc-and-fungal/burden.html
Jacobs SE, Zagaliotis P, Walsh TJ. Novel antifungal agents in clinical trials. F1000Res. 2021 Jun 28;10:507. DOI: https://doi.org/10.12688/f1000research.28327.1
Vera-González N, Shukla A. Advances in Biomaterials for the Prevention and Disruption of Candida Biofilms. Front Microbiol. 2020 Sep 17;11:538602. DOI: https://doi.org/10.3389/fmicb.2020.538602
Espiritu MJ, Collier AC, Bingham JP. A 21st-century approach to age-old problems: the ascension of biologics in clinical therapeutics. Drug Discov Today. 2014 Aug;19(8):1109–13. DOI: https://doi.org/10.1016/j.drudis.2014.01.008
Singer AJ, Hirth D, McClain SA, Crawford L, Lin F, Clark RAF. Validation of a vertical progression porcine burn model. J Burn Care Res. 2011 Nov-Dec;32(6):638–46. DOI: https://doi.org/10.1097/BCR.0b013e31822dc439
Prasad A, Lin F, Clark RAF. Fibronectin-derived Epiviosamines enhance PDGF-BB-stimulated human dermal fibroblast migration in vitro and granulation tissue formation in vivo. Wound Repair Regen. 2019 Nov;27(6):634–49. DOI: https://doi.org/10.1111/wrr.12744
Lin F, Prasad A, Weber-Fishkin S, Clark RA. Engineered Fibronectin Peptide Resists Elastase Digestion, Speeds Healing, and Attenuates Scarring in Porcine Burns. J Invest Dermatol. 2020 Jul;140(7):1480–3. DOI: https://doi.org/10.1016/j.jid.2019.10.021
Macri LK, Sheihet L, Singer AJ, Kohn J, Clark RAF. Ultrafast and fast bioerodible electrospun fiber mats for topical delivery of a hydrophilic peptide. J Control Release. 2012 Aug 10;161(3):813–20. DOI: https://doi.org/10.1016/j.jconrel.2012.04.035
Jain S, John A, George CE, Johnson RP. Tyrosine-Derived Polymers as Potential Biomaterials: Synthesis Strategies, Properties, and Applications. Biomacromolecules. 2023 Feb 13;24(2):531–65. DOI: https://doi.org/10.1021/acs.biomac.2c01232
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 The copyright to the submitted manuscript is held by the Author, who grants the Journal of Medical Science (JMS) a nonexclusive licence to use, reproduce, and distribute the work, including for commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Accepted 2023-09-13
Published 2023-09-29
