Insights into solid dosage forms with nonlinear optical imaging

Teemu Tomberg; Alba Maria Arbiol Enguita; Clare J. Strachan

doi:10.20883/medical.e914

Authors

Teemu J. Tomberg Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland https://orcid.org/0000-0003-3448-2880
Alba Maria Arbiol Enguita Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland https://orcid.org/0009-0009-8721-4100
Clare J. Strachan Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland https://orcid.org/0000-0003-3134-8918

DOI:

https://doi.org/10.20883/medical.e914

Keywords:

solid-state, chemical imaging, coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), second harmonic generation (SHG), pharmaceutical

Abstract

Microscopic chemical and solid-state structures and their changes in solid drugs and dosage forms can profoundly affect pharmaceutical performance and patient safety. Despite this, their detailed spatially-resolved analysis can be difficult or impossible with established analytical technologies. Multimodal non-linear optical imaging presents opportunities for sensitive and specific chemical and solid-state pharmaceutical imaging. Non-linear optical imaging encompasses several nonlinear optical phenomena, including coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), and sum frequency/second harmonic generation (SFG/SHG). Imaging in 3D with (sub)micron resolution is rapid, non-destructive, possible in situ in aqueous media, and generally does not require prior sample preparation. This mini-review explores several applications of non-linear optical imaging for solid drug and dosage form analysis.

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Author Biography

Teemu J. Tomberg, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Postdoctoral researcher, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy

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