Impact of testosterone levels and testosterone replacement therapy on men’s health

Authors

  • Zuzanna Karbowska Faculty of Medicine, Poznan University od Medical Sciences, Poland
  • Katarzyna Cierpiszewska Faculty of Medicine, Poznan University of Medical Sciences, Poland
  • Klara Maruszczak Faculty of Medicine, Poznan University of Medical Sciences, Poland
  • Ivanna Sukhachova Faculty of Medicine, Poznan University of Medical Sciences, Poland
  • Dominika Szwankowska Faculty of Medicine, Poznan University of Medical Sciences, Poland
  • Igor Piotrowski Department of Electroradiology, Poznan University of Medical Sciences, Poland; Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poland https://orcid.org/0000-0002-4985-9321

DOI:

https://doi.org/10.20883/medical.e856

Keywords:

testosterone, testosterone deficiency, functional hypogonadism, late-onset hypogonadism (LOH), testosterone replacement therapy (TRT)

Abstract

Various studies have shown that testosterone levels have a heavy impact on areas of a man’s health. Low serum testosterone (and, by analogy, late-onset hypogonadism) may be responsible for such conditions as type 2 diabetes, obesity in the abdominal area, and, most of all, heightened cardiovascular risk (CV). Among other outcomes, researchers have pointed out metabolic syndrome and dyslipidemia, as well as an increased risk of anxiety disorders and major depressive disorders. There have also been reports of testosterone’s influence on fertility, bone mineral density, and the development of polycythemia. Low testosterone can have a variety of effects, all of which increase the risk of premature death by raising inflammatory marker levels.

Overly high testosterone, however, has been proven to have a notable influence on men's personalities, as well as other psychological and social traits, both in endogenously elevated testosterone levels and in patients with a history of anabolic-androgenic steroid use.

The last decade’s research on testosterone’s impact on the organism has yielded contradictory results. Therefore, examination and understanding of the influence of its abnormal levels prove essential to not only guarantee the best quality of hypogonadism treatment but also to efficiently prevent any side effects or complications associated with testosterone use.

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References

Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR; Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001 Feb;86(2):724-31. doi: 10.1210/jcem.86.2.7219. PMID: 11158037. DOI: https://doi.org/10.1210/jcem.86.2.7219

Üçer O, Gümüş B. The treatment of late-onset hypogonadism. Turk J Urol. 2014 Sep;40(3):170-9. doi: 10.5152/tud.2013.97752. Epub 2014 Mar 24. PMID: 26328172; PMCID: PMC4548387. DOI: https://doi.org/10.5152/tud.2013.97752

Salter CA, Mulhall JP. Guideline of guidelines: testosterone therapy for testosterone deficiency. BJU Int. 2019 Nov;124(5):722-729. doi: 10.1111/bju.14899. Epub 2019 Sep 11. PMID: 31420972. DOI: https://doi.org/10.1111/bju.14899

Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, Vanderschueren D, Wu FC. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology. Andrology. 2020 Sep;8(5):970-987. doi: 10.1111/andr.12770. Epub 2020 Mar 20. PMID: 32026626. DOI: https://doi.org/10.1111/andr.12770

Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006 Mar 15;295(11):1288-99. doi: 10.1001/jama.295.11.1288. PMID: 16537739. DOI: https://doi.org/10.1001/jama.295.11.1288

Muraleedharan V, Marsh H, Kapoor D, Channer KS, Jones TH. Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. Eur J Endocrinol. 2013 Oct 21;169(6):725-33. doi: 10.1530/EJE-13-0321. PMID: 23999642. DOI: https://doi.org/10.1530/EJE-13-0321

Boden WE, Miller MG, McBride R, Harvey C, Snabes MC, Schmidt J, McGovern ME, Fleg JL, Desvigne-Nickens P, Anderson T, Kashyap M, Probstfield JL. Testosterone concentrations and risk of cardiovascular events in androgen-deficient men with atherosclerotic cardiovascular disease. Am Heart J. 2020 Jun;224:65-76. doi: 10.1016/j.ahj.2020.03.016. Epub 2020 Mar 20. PMID: 32335402. DOI: https://doi.org/10.1016/j.ahj.2020.03.016

Lester JF, Mason MD. Cardiovascular effects of hormone therapy for prostate cancer. Drug Healthc Patient Saf. 2015 Jul 23;7:129-38. doi: 10.2147/ DHPS.S50549. PMID: 26229507; PMCID: PMC4516188.

Rodriguez A, Muller DC, Metter EJ, Maggio M, Harman SM, Blackman MR, Andres R. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab. 2007 Sep;92(9):3568-72. doi: 10.1210/ jc.2006-2764. Epub 2007 Jun 26. PMID: 17595254. DOI: https://doi.org/10.1210/jc.2006-2764

Rodrigo Blaya, Leonardo Dalla Giacomassa Rocha Thomaz, Fernanda Guilhermano, Artur de Oliveira Paludo, Luiza Rhoden, Graziele Halmenschlager & Ernani Luis Rhoden (2016) Total testosterone levels are correlated to metabolic syndrome components, The Aging Male, 19:2, 85-89, DOI: 10.3109/13685538.2016.1154523 DOI: https://doi.org/10.3109/13685538.2016.1154523

Fantus RJ, Chang C, Platz EA, Bennett NE, Helfand BT, Brannigan RE, Halpern JA. Serum Total Testosterone and Premature Mortality Among Men in the USA. Eur Urol Open Sci. 2021 Jun 7;29:89-92. doi: 10.1016/j.euros.2021.05.008. PMID: 34337538; PMCID: PMC8317905. DOI: https://doi.org/10.1016/j.euros.2021.05.008

Çatakoğlu AB, Kendirci M. Testosterone replacement therapy and cardiovascular events. Turk Kardiyol Dern Ars. 2017 Oct;45(7):664-672. doi: 10.5543/tkda.2017.00531. PMID: 28990951. DOI: https://doi.org/10.5543/tkda.2017.00531

Ide V, Vanderschueren D, Antonio L. Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy. Int J Mol Sci. 2020 Dec 22;22(1):21. doi: 10.3390/ijms22010021. PMID: 33375030; PMCID: PMC7792781. DOI: https://doi.org/10.3390/ijms22010021

Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev. 1987 Feb;8(1):1-28. doi: 10.1210/edrv-8-1-1. PMID: 3549275. DOI: https://doi.org/10.1210/edrv-8-1-1

Xu HY, Zhang HX, Xiao Z, Qiao J, Li R. Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility. Asian J Androl. 2019 Mar-Apr;21(2):109-114. doi: 10.4103/aja.aja_83_18. PMID: 30381580; PMCID: PMC6413543. DOI: https://doi.org/10.4103/aja.aja_83_18

Pinyerd B, Zipf WB. Puberty-timing is everything! J Pediatr Nurs. 2005 Apr;20(2):75-82. doi: 10.1016/j.pedn.2004.12.011. PMID: 15815567. DOI: https://doi.org/10.1016/j.pedn.2004.12.011

Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Semin Cell Dev Biol. 2014 Jun;30:2-13. doi: 10.1016/j.semcdb.2014.02.012. Epub 2014 Mar 2. PMID: 24598768; PMCID: PMC4043871. DOI: https://doi.org/10.1016/j.semcdb.2014.02.012

Sapienza P, Zingales L, Maestripieri D. Gender differences in financial risk aversion and career choices are affected by testosterone. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15268-73. doi: 10.1073/pnas.0907352106. Epub 2009 Aug 24. PMID: 19706398; PMCID: PMC2741240. DOI: https://doi.org/10.1073/pnas.0907352106

Beauchet O. Testosterone and cognitive function: current clinical evidence of a relationship. Eur J Endocrinol. 2006 Dec;155(6):773-81. doi: 10.1530/eje.1.02306. PMID: 17132744. DOI: https://doi.org/10.1530/eje.1.02306

Bianchi VE. The Anti-Inflammatory Effects of Testosterone. J Endocr Soc. 2018 Oct 22;3(1):91-107. doi: 10.1210/js.2018-00186. PMID: 30582096; PMCID: PMC6299269. DOI: https://doi.org/10.1210/js.2018-00186

Corona G, Rastrelli G, Di Pasquale G, Sforza A, Mannucci E, Maggi M. Endogenous Testosterone Levels and Cardiovascular Risk: Meta-Analysis of Observational Studies. J Sex Med. 2018 Sep;15(9):1260-1271. doi: 10.1016/j.jsxm.2018.06.012. Epub 2018 Aug 23. PMID: 30145097. DOI: https://doi.org/10.1016/j.jsxm.2018.06.012

Marriott RJ, Harse J, Murray K, Yeap BB. Systematic review and meta-analyses on associations of endogenous testosterone concentration with health outcomes in community-dwelling men. BMJ Open. 2021 Nov 2;11(11):e048013. doi: 10.1136/bmjopen-2020-048013. PMID: 34728442; PMCID: PMC8565564. DOI: https://doi.org/10.1136/bmjopen-2020-048013

Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, Eder R, Tennstedt S, Ulloor J, Zhang A, Choong K, Lakshman KM, Mazer NA, Miciek R, Krasnoff J, Elmi A, Knapp PE, Brooks B, Appleman E, Aggarwal S, Bhasin G, Hede-Brierley L, Bhatia A, Collins L, LeBrasseur N, Fiore LD, Bhasin S. Adverse events associated with testosterone administration. N Engl J Med. 2010 Jul 8;363(2):109-22. doi: 10.1056/NEJMoa1000485. Epub 2010 Jun 30. PMID: 20592293; PMCID: PMC3440621. DOI: https://doi.org/10.1056/NEJMoa1000485

Xu L, Freeman G, Cowling BJ, Schooling CM. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med. 2013 Apr 18;11:108. doi: 10.1186/1741-7015-11-108. PMID: 23597181; PMCID: PMC3648456. DOI: https://doi.org/10.1186/1741-7015-11-108

Vigen R, O'Donnell CI, Barón AE, Grunwald GK, Maddox TM, Bradley SM, Barqawi A, Woning G, Wierman ME, Plomondon ME, Rumsfeld JS, Ho PM. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013 Nov 6;310(17):1829-36. doi: 10.1001/jama.2013.280386. Erratum in: JAMA. 2014 Mar 5;311(9):967. PMID: 24193080. DOI: https://doi.org/10.1001/jama.2013.280386

Finkle WD, Greenland S, Ridgeway GK, Adams JL, Frasco MA, Cook MB, Fraumeni JF Jr, Hoover RN. Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men. PLoS One. 2014 Jan 29;9(1):e85805. doi: 10.1371/journal.pone.0085805. PMID: 24489673; PMCID: PMC3905977. DOI: https://doi.org/10.1371/journal.pone.0085805

Corona G, Rastrelli G, Di Pasquale G, Sforza A, Mannucci E, Maggi M. Testosterone and Cardiovascular Risk: Meta-Analysis of Interventional Studies. J Sex Med. 2018 Jun;15(6):820-838. doi: 10.1016/j.jsxm.2018.04.641. PMID: 29803351. DOI: https://doi.org/10.1016/j.jsxm.2018.04.641

Fallara G, Pozzi E, Belladelli F, Corsini C, Boeri L, Capogrosso P, Montorsi F, Salonia A. Cardiovascular Morbidity and Mortality in Men - Findings From a Meta-analysis on the Time-related Measure of Risk of Exogenous Testosterone. J Sex Med. 2022 Aug;19(8):1243-1254. doi: 10.1016/j.jsxm.2022.05.145. Epub 2022 Jun 23. PMID: 35753891. DOI: https://doi.org/10.1016/j.jsxm.2022.05.145

Hudson J, Cruickshank M, Quinton R, Aucott L, Aceves-Martins M, Gillies K, Bhasin S, Snyder PJ, Ellenberg SS, Grossmann M, Travison TG, Gianatti EJ, van der Schouw YT, Emmelot-Vonk MH, Giltay EJ, Hackett G, Ramachandran S, Svartberg J, Hildreth KL, Groti Antonic K, Brock GB, Tenover JL, Tan HM, Kong CHC, Tan WS, Marks LS, Ross RJ, Schwartz RS, Manson P, Roberts S, Andersen MS, Magnussen LV, Hernández R, Oliver N, Wu F, Dhillo WS, Bhattacharya S, Brazzelli M, Jayasena CN. Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis. Lancet Healthy Longev. 2022 Jun;3(6):e381-e393. doi: 10.1016/S2666-7568(22)00096-4. PMID: 35711614; PMCID: PMC9184259. DOI: https://doi.org/10.1016/S2666-7568(22)00096-4

Ayele HT, Brunetti VC, Renoux C, Tagalakis V, Filion KB. Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials. Thromb Res. 2021 Mar;199:123-131. doi: 10.1016/j.thromres.2020.12.029. Epub 2021 Jan 6. PMID: 33486321. DOI: https://doi.org/10.1016/j.thromres.2020.12.029

Mangolim AS, Brito LAR, Nunes-Nogueira VDS. Effectiveness of testosterone replacement in men with obesity: a systematic review and meta-analysis. Eur J Endocrinol. 2021 Dec 3;186(1):123-135. doi: 10.1530/EJE-21-0473. PMID: 34738915. DOI: https://doi.org/10.1530/EJE-21-0473

Cannarella R, Barbagallo F, Crafa A, Mongioì LM, Aversa A, Greco E, Condorelli RA, LA Vignera S, Calogero AE. Testosterone replacement therapy in hypogonadal male patients with hypogonadism and heart failure: a meta-analysis of randomized controlled studies. Minerva Urol Nephrol. 2022 Aug;74(4):418-427. doi: 10.23736/S2724-6051.21.04307-X. Epub 2021 Mar 29. PMID: 33781026. DOI: https://doi.org/10.23736/S2724-6051.21.04307-X

Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, Boden WE, Cunningham GR, Granger CB, Khera M, Thompson IM Jr, Wang Q, Wolski K, Davey D, Kalahasti V, Khan N, Miller MG, Snabes MC, Chan A, Dubcenco E, Li X, Yi T, Huang B, Pencina KM, Travison TG, Nissen SE; TRAVERSE Study Investigators. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023 Jul 13;389(2):107-117. doi: 10.1056/NEJMoa2215025. Epub 2023 Jun 16. PMID: 37326322. DOI: https://doi.org/10.1056/NEJMoa2215025

Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T. Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum Reprod Update. 2018 Jan 1;24(1):86-105.doi:10.1093/humupd/ dmx033. PMID: 29136166. DOI: https://doi.org/10.1093/humupd/dmx033

Corona G, Maggi M. Patients with testosterone deficiency syndrome and type 2 diabetes. Arch Esp Urol. 2013 Sep;66(7):711-22. PMID: 24047631.

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R; IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov;157:107843. doi: 10.1016/j.diabres.2019.107843. Epub 2019 Sep 10. PMID: 31518657. DOI: https://doi.org/10.1016/j.diabres.2019.107843

Kumari N, Khan A, Shaikh U, Lobes K, Kumar D, Suman F, Bhutto NS, Anees F, Shahid S, Rizwan A. Comparison of Testosterone Levels in Patients With and Without Type 2 Diabetes. Cureus. 2021 Jul 9;13(7): e16288.doi:10.7759/cureus. 16288. PMID: 34381648; PMCID: PMC8350217. DOI: https://doi.org/10.7759/cureus.16288

Leutner M, Matzhold C, Bellach L, Wohlschläger-Krenn E, Winker R, Nistler S, Endler G, Thurner S, Klimek P, Kautzky-Willer A. Increase in testosterone levels is related to a lower risk of conversion of prediabetes to manifest diabetes in prediabetic males. Wien Klin Wochenschr. 2022 Jan;134(1-2):1-6. doi: 10.1007/ s00508-021-01903-1. Epub 2021 Jul 5. PMID: 34223999; PMCID: PMC8813729. DOI: https://doi.org/10.1007/s00508-021-01903-1

Gouda SI, Aboelnaga MM, Elbeltagy AMG, Elbaz A. Testosterone deficiency in non-obese type 2 diabetic male patients. Arch Ital Urol Androl. 2022 Dec 27;94(4):464-469. doi: 10.4081/aiua.2022.4.464. PMID: 36576479. DOI: https://doi.org/10.4081/aiua.2022.4.464

Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F. Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab. 2016 May 10;23(5):837-51. doi: 10.1016/ j.cmet.2016.03.015. Epub 2016 Apr 28. PMID: 27133133; PMCID: PMC4864089. DOI: https://doi.org/10.1016/j.cmet.2016.03.015

Yassin A, Haider A, Haider KS, Caliber M, Doros G, Saad F, Garvey WT. Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study. Diabetes Care. 2019 Jun;42(6):1104-1111. doi: 10.2337/dc18-2388. Epub 2019 Mar 12. PMID: 30862651. DOI: https://doi.org/10.2337/dc18-2388

Boyanov MA, Boneva Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male. 2003 Mar;6(1):1-7. PMID: 12809074. DOI: https://doi.org/10.1080/tam.6.1.1.7

Hautanen A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S64-70. doi: 10.1038/ sj.ijo.0801281. PMID: 10997612. Int J Obes Relat Metab Disord 2000; 24 Suppl 2: S64–70. DOI: https://doi.org/10.1038/sj.ijo.0801281

Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004 May;27(5):1036-41. doi: 10.2337/diacare.27.5.1036. PMID: 15111517. DOI: https://doi.org/10.2337/diacare.27.5.1036

Vermeulen A, Goemaere S, Kaufman JM. Testosterone, body composition and aging. J Endocrinol Invest. 1999;22(5 Suppl):110-6. PMID: 10442580.

LeBlanc ES, Wang PY, Lee CG, Barrett-Connor E, Cauley JA, Hoffman AR, Laughlin GA, Marshall LM, Orwoll ES. Higher testosterone levels are associated with less loss of lean body mass in older men. J Clin Endocrinol Metab. 2011 Dec;96(12):3855-63. doi: 10.1210/jc.2011-0312. Epub 2011 Oct 5. PMID: 21976718; PMCID: PMC3232620. DOI: https://doi.org/10.1210/jc.2011-0312

Bauman WA, Cirnigliaro CM, La Fountaine MF, Jensen AM, Wecht JM, Kirshblum SC, Spungen AM. A small-scale clinical trial to determine the safety and efficacy of testosterone replacement therapy in hypogonadal men with spinal cord injury. Horm Metab Res. 2011 Jul;43(8):574-9. doi: 10.1055/s-0031-1280797. Epub 2011 Jun 29. PMID: 21717386. DOI: https://doi.org/10.1055/s-0031-1280797

Grinspoon S, Corcoran C, Askari H, Schoenfeld D, Wolf L, Burrows B, Walsh M, Hayden D, Parlman K, Anderson E, Basgoz N, Klibanski A. Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998 Jul 1;129(1):18-26. doi: 10.7326/0003-4819-129-1-199807010-00005. PMID: 9652995. DOI: https://doi.org/10.7326/0003-4819-129-1-199807010-00005

Kaipainen A, Zhang A, Gil da Costa RM, Lucas J, Marck B, Matsumoto AM, Morrissey C, True LD, Mostaghel EA, Nelson PS. Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion. Prostate. 2019 Sep;79(13):1530-1542. doi: 10.1002/pros.23874. Epub 2019 Aug 2. PMID: 31376206;PMCID: PMC6783279. DOI: https://doi.org/10.1002/pros.23874

Claps M, Petrelli F, Caffo O, Amoroso V, Roca E, Mosca A, Maines F, Barni S, Berruti A. Testosterone Levels and Prostate Cancer Prognosis: Systematic Review and Meta-analysis. Clin Genitourin Cancer. 2018 Jun;16(3):165-175.e2. doi: 10.1016/j.clgc.2018.01.005. Epub 2018 Feb 2. PMID: 29454638. DOI: https://doi.org/10.1016/j.clgc.2018.01.005

Walsh TJ, Shores MM, Krakauer CA, Forsberg CW, Fox AE, Moore KP, Korpak A, Heckbert SR, Zeliadt SB, Kinsey CE, Thompson ML, Smith NL, Matsumoto AM. Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels. PLoS One. 2018 Jun 22;13(6):e0199194. doi: 10.1371/ journal.pone.0199194. PMID: 29933385; PMCID: PMC6014638. DOI: https://doi.org/10.1371/journal.pone.0199194

Morales A, Black A. Testosterone deficiency syndrome and prostate cancer: illustrative annotations for a debate. Can Urol Assoc J. 2008 Feb;2(1):52-4. doi: 10.5489/cuaj.528. PMID: 18542732; PMCID: PMC2422889. DOI: https://doi.org/10.5489/cuaj.528

Khosla S, Monroe DG. Regulation of Bone Metabolism by Sex Steroids. Cold Spring Harb Perspect Med. 2018 Jan 2;8(1):a031211. doi: 10.1101/cshperspect.a031211. PMID: 28710257; PMCID: PMC5749141. DOI: https://doi.org/10.1101/cshperspect.a031211

Golds G, Houdek D, Arnason T. Male Hypogonadism and Osteoporosis: The Effects, Clinical Consequences, and Treatment of Testosterone Deficiency in Bone Health. Int J Endocrinol. 2017;2017:4602129. doi: 10.1155/2017/4602129. Epub 2017 Mar 16. PMID: 28408926; PMCID: PMC5376477. DOI: https://doi.org/10.1155/2017/4602129

Bandeira L, Silva BC, Bilezikian JP. Male osteoporosis. Arch Endocrinol Metab. 2022 Nov 11;66(5):739-747. doi: 10.20945/2359-3997000000563. PMID: 36382763; PMCID: PMC10118818. DOI: https://doi.org/10.20945/2359-3997000000563

Stĕpán JJ, Lachman M, Zvĕrina J, Pacovský V, Baylink DJ. Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab. 1989 Sep;69(3):523-7. doi: 10.1210/jcem-69-3-523. PMID: 2788171. DOI: https://doi.org/10.1210/jcem-69-3-523

Hocking WG, Golde DW. Polycythemia: evaluation and management. Blood Rev. 1989 Mar;3(1):59-65. doi: 10.1016/0268-960x(89)90026-x. PMID: 2650777. DOI: https://doi.org/10.1016/0268-960X(89)90026-X

Randi ML, Bertozzi I, Cosi E, Santarossa C, Peroni E, Fabris F. Idiopathic erythrocytosis: a study of a large cohort with a long follow-up. Ann Hematol. 2016 Jan;95(2):233-7. doi: 10.1007/s00277-015-2548-z. Epub 2015 Nov 7. PMID: 26547864. DOI: https://doi.org/10.1007/s00277-015-2548-z

Haider MZ, Anwer F. Secondary Polycythemia. 2023 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32965904.

Bachman E, Travison TG, Basaria S, Davda MN, Guo W, Li M, Connor Westfall J, Bae H, Gordeuk V, Bhasin S. Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):725-35. doi: 10.1093/gerona/glt154. Epub 2013 Oct 24. PMID: 24158761; PMCID: PMC4022090. DOI: https://doi.org/10.1093/gerona/glt154

Levcikova M, Breza J Jr, Luha J, Dubravicky J, Kovacova E, Fillo J. Testosterone replacement therapy (TRT) and its effect on bone marrow. How serious is it and is there a true polyglobulia? Bratisl Lek Listy. 2017;118(11):654-657. doi: 10.4149/BLL_2017_124. PMID: 29216720. DOI: https://doi.org/10.4149/BLL_2017_124

Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, Morley JE, Schulman C, Thompson IM, Weidner W, Wu FC. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol. 2008 Nov;159(5):507-14. doi: 10.1530/EJE-08-0601. PMID: 18955511; PMCID: PMC2754376. DOI: https://doi.org/10.1530/EJE-08-0601

Bassil N, Alkaade S, Morley JE. The benefits and risks of testosterone replacement therapy: a review. Ther Clin Risk Manag. 2009 Jun;5(3):427-48. doi: 10.2147/tcrm.s3025. Epub 2009 Jun 22. PMID: 19707253; PMCID: PMC2701485.

Christou MA, Christou PA, Markozannes G, Tsatsoulis A, Mastorakos G, Tigas S. Effects of Anabolic Androgenic Steroids on the Reproductive System of Athletes and Recreational Users: A Systematic Review and Meta-Analysis. Sports Med. 2017 Sep;47(9):1869-1883. doi: 10.1007/s40279-017-0709-z. PMID: 28258581. DOI: https://doi.org/10.1007/s40279-017-0709-z

Rastrelli G, Corona G, Mannucci E, Maggi M. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology. 2014 Nov;2(6):794-808. doi: 10.1111/andr.262. Epub 2014 Oct 1. PMID: 25271205. DOI: https://doi.org/10.1111/andr.262

James M. Dabbs, Timothy S. Carr, Robert L. Frady, Jasmin K. Riad, Testosterone, crime, and misbehavior among 692 male prison inmates, Personality and Individual Differences, Volume 18, Issue 5, 1995, Pages 627-633, ISSN 0191-8869, https://doi.org/10.1016/0191-8869(94)00177-T. DOI: https://doi.org/10.1016/0191-8869(94)00177-T

Dabbs JM Jr, Frady RL, Carr TS, Besch NF. Saliva testosterone and criminal violence in young adult prison inmates. Psychosom Med. 1987 Mar- Apr;49(2):174-82. doi: 10.1097/00006842-198703000-00007. PMID: 3575604. DOI: https://doi.org/10.1097/00006842-198703000-00007

Anu S Aromäki, Ralf E Lindman, C.J.Peter Eriksson, Testosterone, sexuality and antisocial personality in rapists and child molesters: a pilot study, Psychiatry Research, Volume 110, Issue 3, 2002, Pages 239-247, ISSN 0165-1781, https://doi.org/10.1016/S0165-1781(02)00109-9. DOI: https://doi.org/10.1016/S0165-1781(02)00109-9

House, S.J., Laan, J.M., Molden, R.K., Ritchie, J.C. and Stowe, Z.N. (2017), Preliminary Study of Testosterone and Empathy in Determining Recidivism and Antisocial Behavior. J Forensic Sci, 62: 1360-1365. https://doi.org/ 10.1111/1556-4029.13469 DOI: https://doi.org/10.1111/1556-4029.13469

Coccaro EF, Beresford B, Minar P, Kaskow J, Geracioti T. CSF testosterone: relationship to aggression, impulsivity, and venturesomeness in adult males with personality disorder. J Psychiatr Res. 2007 Sep;41(6):488-92. doi: 10.1016/ j.jpsychires.2006.04.009. PMID: 16765987. DOI: https://doi.org/10.1016/j.jpsychires.2006.04.009

Yildirim BO, Derksen JJ. A review on the relationship between testosterone and life-course persistent antisocial behavior. Psychiatry Res. 2012 Dec 30;200(2-3):984-1010. doi: 10.1016/j.psychres.2012.07.044. Epub 2012 Aug 25. PMID: 22925371. DOI: https://doi.org/10.1016/j.psychres.2012.07.044

Welker KM, Lozoya E, Campbell JA, Neumann CS, Carré JM. Testosterone, cortisol, and psychopathic traits in men and women. Physiol Behav. 2014 Apr 22;129:230-6. doi: 10.1016/j.physbeh.2014.02.057. Epub 2014 Mar 11. PMID: 24631306. DOI: https://doi.org/10.1016/j.physbeh.2014.02.057

Dreher JC, Dunne S, Pazderska A, Frodl T, Nolan JJ, O'Doherty JP. Testosterone causes both prosocial and antisocial status-enhancing behaviors in human males. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11633-11638. doi: 10.1073/pnas.1608085113. Epub 2016 Sep 26. PMID: 27671627; PMCID: PMC5068300. DOI: https://doi.org/10.1073/pnas.1608085113

Lisa E. Hauger, Ingrid A. Havnes, Marie L. Jørstad, Astrid Bjørnebekk, Anabolic androgenic steroids, antisocial personality traits, aggression and violence, Drug and Alcohol Dependence, Volume 221, 2021, 108604, ISSN 0376-8716, https://doi.org/ 10.1016/j.drugalcdep.2021.108604 DOI: https://doi.org/10.1016/j.drugalcdep.2021.108604

Piacentino D, Kotzalidis GD, Del Casale A, Aromatario MR, Pomara C, Girardi P, Sani G. Anabolic-androgenic steroid use and psychopathology in athletes. A systematic review. Curr Neuropharmacol. 2015 Jan;13(1):101-21. doi: 10.2174/1570159X13666141210222725. PMID: 26074746; PMCID: PMC4462035. DOI: https://doi.org/10.2174/1570159X13666141210222725

McHenry J, Carrier N, Hull E, Kabbaj M. Sex differences in anxiety and depression: role of testosterone. Front Neuroendocrinol. 2014 Jan;35(1):42-57. doi: 10.1016/j.yfrne.2013.09.001. Epub 2013 Sep 24. PMID: 24076484; PMCID: PMC3946856. DOI: https://doi.org/10.1016/j.yfrne.2013.09.001

Li D, Liu R, Wang M, Peng R, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z, Wang G, Li Y, Liu T. 3β- Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host Microbe. 2022 Mar 9;30(3):329-339.e5. doi: 10.1016/j.chom.2022.01.001. Epub 2022 Feb 1. PMID: 35108497. DOI: https://doi.org/10.1016/j.chom.2022.01.001

Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M. Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract. 2009 Jul;15(4):289-305. doi: 10.1097/01.pra.0000358315.88931.fc. PMID: 19625884. DOI: https://doi.org/10.1097/01.pra.0000358315.88931.fc

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2023-12-07

How to Cite

1.
Karbowska Z, Cierpiszewska K, Maruszczak K, Sukhachova I, Szwankowska D, Piotrowski I. Impact of testosterone levels and testosterone replacement therapy on men’s health. JMS [Internet]. 2023 Dec. 7 [cited 2024 Jun. 16];93(1):e856. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/856

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Review Papers
Received 2023-05-17
Accepted 2023-09-22
Published 2023-12-07