Published: 2016-02-17

Ketoprofen, an emerging photoallergen

Heliodor Święcicki University Hospital, Poznan University of Medical Sciences, Poland
Department of Dermatology, Poznan University of Medical Sciences, Poland
Department of Dermatology, Poznan University of Medical Sciences, Poland
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poland
Department of Dermatology, Poznan University of Medical Sciences, Poland
ketoprofen photoallergic contact dermatitis photoallergy photosensitivity photopatch testing


Introduction. Ketoprofen, which belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), is an emerging photoallergen. Especially its topical use may be a cause of drug-induced photosensitivity.
Material and methods. We report two cases of photoallergic and one case of phototaggravated contact dermatitis due to topical ketoprofen application, confirmed by photopatch testing.
Results. All patients presented positive reactions to ketoprofen at an irradiated site. Only one patient demonstrated a positive reaction to ketoprofen both at an irradiated and non-irradiated site.
Conclusions. Photosensitive reactions due to topical application of ketoprofen being of significant clinical importance need to be properly diagnosed. It is crucial to provide patients with a detailed instruction how to protect photoexposed areas during therapy with ketoprofen.


Download data is not yet available.


  1. Alomar A. Ketoprofen photodermatitis. Contact Dermatitis. 1985 Feb;12(2):112–113.
  2. Mozzanica N, Pigatto P. Contact and photocontact allergy to ketoprofen: clinical and experimental study. Contact Dermatitis. 1990 Nov;23(5):336–340.
  3. Sugiura M, Hayakawa R, Kato Y, Sugiura K, Ueda H. 4 cases of photocontact dermatitis due to ketoprofen. Contact Dermatitis. 2000 Jul;43(1):16–19.
  4. Sugiyama M, Nakada T, Hosaka H, Sueki H, Iijima M. Photocontact dermatitis to ketoprofen. Am J Contact Dermatitis. 2001 Sep;12(3):180–181.
  5. Matthieu L, Meuleman L, Van Hecke E, Van Hecke E, Blondeel A, Dezfoulian B, et al. Contact and photocontact allergy to ketoprofen. The Belgian experience. Contact Dermatitis. 2004;50(4):238–241.
  6. Hindsenn M, Zimerson E, Bruze M. Photoallergic contact dermatitis from ketoprofen in southern Sweden. Contact Dermatitis. 2006 Mar;54(3):150–157.
  7. Jenerowicz D, Jakubowicz O, Polańska A, Sadowska-Przytocka A, Dańczak-Pazdrowska A, Żaba R. Photosensitivity to selected topical nonsteroidal anti-inflammatory drugs preparations – a review of literature dataand author’s own experience. Centr Eur J Immunol. 2001;36 (3): 197–203.
  8. Bruynzeel DP, Ferguson F, Andersen KM. Gonçalo M, English J, Goossens A, et al. Photopatch testing: a consensus methodology for Europe. J Eur Acad Dermatol Venereol. 2004 Nov;18(6): 679–682.
  9. Kerr AC, Ferguson J, Haylett AK, Rhodes LE, Adamski H, Alomar A, et al. AEuropean multicentre photopatch test study. Br J Dermatol. 2012 May;166(5):1002–1009.
  10. Chuah SY, Leow YH, Goon AT, Theng CT, Chong WS. Photopatch testing in Asians: a 5-year experience in Singapore. Photodermatol Photoimmunol Photomed. 2013 Jun; 29(3):116–120.
  11. De la Cuadra-Oyanguren J, Pérez-Ferriols A, Lecha-Carrelero M, Gimenez-Arnau AM, Fernandez-Redondo V, Ortiz de Frutos FJ, et al. Results and Assessment of Photopatch Testing in Spain:Towards a New Standard Set of Photoallergens. Actas Dermosifiliogr. 2007 Mar;98(2):96–101.
  12. Foti C, Cassano N, Vena GA, Angelini G. Photodermatitis caused by oral ketoprofen: two case reports. Contact Dermatitis. 2011 Mar;64(3):181–183.
  13. Conti R, Bassi A, Difonzo EM, Moretti S, Francalanci S. A case of photoallergic contact dermatitis caused by unusual exposure to ketoprofen. Dermatitis. 2012 Nov-Dec;23(6):295–296.
  14. Avenel-Audran M, Dutartre H, Goossens An, Jeanmougin M, Comte Ch, Bernier C, et al. Octocrylene, an Emerging Photoallergen. Arch Dermatol. 2010 Jul;146(7):753–775.
  15. Devleeschouwer V, Roelandts R, Garmyn M, Goossens A. Allergic and photoallergic contact dermatitis from ketoprofen: results of (photo) patch testing and follow-up of 42 patients. Contact Dermatitis. 2008 Mar;58(3):159–166.
  16. Atarashi K, Takano M, Kato S, Kuma H, Nakanishi M, Tokura Y. Addition of UA-absorber butyl methoxydibenzoylmethane to topical ketoprofen formulation reduces ketoprofen-photoallergic reaction. J Photochem Photobiol B. 2012 Aug;113:56–62.
  17. European Medicines Agency confirms positive benefit-risk balance of topical formulations of ketoprofen. EA/CMP/465633/2010.
  18. Gonçalo M, Ferguson J, Bonevalle A, Bruynzeel DP, Giménez-Arnau A, Goossens A, et al. Photopatch testing: recommendations for a European photopatch test baseline series. Contact Dermatitis. 2013 Apr;68(4):239–243.

How to Cite

Zuba EB, Osmola-Mańkowska A, Jenerowicz D, Stawny M, Czarnecka-Operacz M. Ketoprofen, an emerging photoallergen. JMS [Internet]. 2016Feb.17 [cited 2020Aug.5];83(3):260-4. Available from: