Liposuction-induced metabolic alterations – the effect on insulin sensitivity, adiponectin, leptin and resistin


  • Magdalena Gibas-Dorna Department of Physiology, Poznan University of Medical Sciences, Poland
  • Piotr Turkowski Samir Ibrahim Mandala Beauty Clinic, Poznan, Poland
  • Małgorzata Bernatek Chair of Social Medicine, Poznan University of Medical Sciences, Poland
  • Kinga Mikrut Department of Physiology, Poznan University of Medical Sciences, Poland
  • Justyna Kupsz Department of Physiology, Poznan University of Medical Sciences, Poland
  • Jacek Piątek Department of Physiology, Poznan University of Medical Sciences, Poland



liposuction, insulin sensitivity, adiponectin, leptin, resistin, metabolic outcomes


Liposuction surgically removes subcutaneous abdominal tissue (SAT) and has almost no effect on visceral abdominal tissue (VAT) depot. However, some authors suggest that deep layers of SAT are functionally similar to VAT and the amount of deep subcutaneous abdominal adipose tissue is strongly related to insulin resistance in a manner nearly identical to that of visceral adiposity. Moreover, SAT determines leptin secretion which indirectly reflects the level of insulin sensitivity in the body. Thus, the immediate removal of SAT could potentially affect metabolic profile of a patient. The current data are conflicting and cannot bring a clear evidence suggesting that liposuction itself results in important metabolic outcomes and, on the other hand, cannot exclude such a possibility. This review summarizes the liposuction-induced metabolic changes with regard to release of major adipokines and insulin sensitivity.


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How to Cite

Gibas-Dorna M, Turkowski P, Bernatek M, Mikrut K, Kupsz J, Piątek J. Liposuction-induced metabolic alterations – the effect on insulin sensitivity, adiponectin, leptin and resistin. JMS [Internet]. 2015 Dec. 30 [cited 2022 Jul. 2];84(4):249-56. Available from:



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