Brain segmentation unmasks association between body composition and central nervous system structures
Keywords:body fat, body mass index, gray matter volume, hippocampus, thalamus, brain segmentation
Introduction. Excess body fat is currently the major health problem. We suggest that marker of fatness like BMI or percent of body fat are associated with gray matter volume (GMV) or brain areas responsible for cognitive functions.
Material and methods. Study was performed in 89 healthy individuals (mean age 58 yrs, 51 women).
For brain segmentation and GMV we used whole-brain, high-resolution 3D T1-weighted images. For assessment of the fat content as a proportion of total body mass a bio-impedance analyzer was used.
Result. GMV was correlated, significantly and negatively with age but was not associated either with BMI nor body fat content. Body fat content was significantly and negatively associated with hippocampus and thalamus.
Conclusion. We demonstrate that brain segmentation was able to unmask the association between body fat content and brain structures particularly involved in cognitive function.
Messerli FH. Cardiovascular effects of obesity and hypertension. Lancet. 1982;2:1165–8.
Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322:882–9.
Abbott RD, Behrens GR, Sharp DS, Rodriguez BL, Burchfiel CM, Ross GW, Yano K, Curb JD. Body mass index and thromboembolic stroke in nonsmoking men in older middle age: the Honolulu Heart Program. Stroke. 1994;25:2370–6.
Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol. 2010;68: 136–44.
Nourhashémi F, Deschamps V, Larrieu S, et al. Personnes Agées Quid. Body mass index and incidence of dementia:the PAQUID study. Neurology. 2003;60:117–9.
Chu LW, Tam S, Lee PW, et al. Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis. 2009; 17:223–32.
Kanaya AM, Lindquist K, Harris TB, et al. Total and regional adiposity and cognitive change in older adults: the Health, Aging and Body Composition (ABC) study. Arch Neurol. 2009;66:329–35.
Gustafson DR, Steen B, Skoog I. Body mass index and white matter lesions in elderly women. An 18-year longitudinal study. Int Psychogeriatr. 2004;16:327–36.
Gustafson D, Lissner L, Bengtsson C, Björkelund C, Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology. 2004;63:1876–81.
Taki Y, Kinomura S, Sato K, Inoue K, Goto R, Okada K, Uchida S, Kawashima R, Fukuda H. Relationship between body mass index and gray matter volume in 1,428 healthy individuals. Obesity. 2008;16:119–24.
Sweatt JD. Hippocampal function in cognition. Psychopharmacology. 2004;174:99–110.
Saalmann YB, Kastner S. Cognitive and perceptual functions of the visual thalamus. Neuron. 2011;28;71: 209–23.
Yoon DH, Choi SH, Yu JH, Ha JH, Ryu SH, Park DH. The relationship between visceral adiposity and cognitive performance in older adults. Age Ageing. 2012;41: 456–61.
Mujica-Parodi LR, Renelique R, Taylor MK. Higher body fat percentage is associated with increased cortisol reactivity and impaired cognitive resilience in response to acute emotional stress. Int J Obes. 2009;33:157–65.
How to Cite
Copyright (c) 2014 Katarzyna Katulska, Mateusz Wykrętowicz, Jarosław Piskorski
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.