App-assured essential physical activity for the prevention of cognitive decline: changing paradigms in public health – a study protocol for a randomised controlled trial: A study protocol of the PA PROTECT study

Małgorzata Jamka; Aleksandra Makarewicz; Maria Wasiewicz-Gajdzis; Jan Brylak; Hanna Wielińska-Wiśniewska; Zuzanna Pawlak; Jan Krzysztof Nowak; Karl-Heinz Herzig; Edyta Mądry; Jarosław Walkowiak

doi:10.20883/medical.e530

Authors

Małgorzata Jamka Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-0257-6180
Aleksandra Makarewicz Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-9310-9643
Maria Wasiewicz-Gajdzis Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-7084-663X
Jan Brylak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0003-1398-3387
Hanna Wielińska-Wiśniewska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-5242-1059
Zuzanna Pawlak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-1947-1481
Jan Krzysztof Nowak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0003-0953-2188
Karl-Heinz Herzig Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland & Research Unit of Biomedicine, University of Oulu, Oulu, Finland https://orcid.org/0000-0003-4460-2604
Edyta Mądry Department of Physiology, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-0081-6558
Jarosław Walkowiak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-5813-5707

DOI:

https://doi.org/10.20883/medical.e530

Keywords:

physical activity, cognitive functions, mild cognitive impairment

Abstract

This study aims to assess the effect of an increase in daily physical activity to prevent cognitive decline, sustain brain volumes and maintain healthy biomarker levels in mild cognitive impairment (MCI) subjects aged 50-70 years. In total, 198 subjects with MCI (assessed using the Montreal Cognitive Assessment test) will be recruited and randomised into two groups: active and passive. The active group will be instructed, encouraged and motivated to increase their physical activity to at least a moderate level (≥ 10,000 steps/day), whereas the passive group should maintain their normal activity levels. All subjects will undergo cognitive assessment, neuroimaging and biomarker tests prior to and after a one-year intervention. During the intervention, physical activity will be measured by the Fitbit Inspire HR wristband. The study was registered in the German Clinical Trials Register database (registration no. DRKS00020943, date of registration: 09.03.2020, protocol version: 1.0).

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