Thousand words about alcohol use disorder in inflammatory bowel disease
DOI:
https://doi.org/10.20883/medical.e506Keywords:
ulcerative colitis, primary sclerosing cholangitis, colorectal cancer, liver transplantation, alcohol use disordersAbstract
Patients with inflammatory bowel disease (IBD), especially those with severe disease and extraintestinal manifestations, are more frequently affected by anxiety and depressive disorders compared to the healthy population. This in turn may favour the expansion of alcohol use disorders but the role of alcohol consumption in the development of IBD and its impact on IBD course remains controversial. Importantly, ethanol is a significant factor contributing to liver failure and increased risk of various malignancies, including colorectal cancer (CRC). Primary sclerosing cholangitis (PSC) is a fatal extraintestinal manifestation of IBD leading to liver failure and promoting the development of cholangiocarcinoma and colorectal cancer. Indeed, alcohol abuse by patients with IBD and PSC may promote the progression of those complications but is difficult to diagnose. The underlying disease may cause similar abnormalities in laboratory and imaging tests to ethanol thus masking the problem, therefore gastroenterologists should pay special attention to the alcohol consumption of IBD patients.
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References
de Souza HSP, Fiocchi C, Iliopoulos D. The IBD interactome: an integrated view of aetiology, pathogenesis and therapy. Nature Reviews Gastroenterology & Hepatology. 2017 Aug 23;14(12):739-749. https://doi.org/10.1038/nrgastro.2017.110
Emek E, Serin A, Sahin T, Yazici P, Yuzer Y, Tokat Y, Bozkurt B. Experience in Liver Transplantation Due to Primary Sclerosing Cholangitis: A Single Center Experience. Transplantation Proceedings. 2019 Sep;51(7):2439-2441. https://doi.org/10.1016/j.transproceed.2019.01.156
Alcohol. World Health Organization. https://www.who.int/health-topics/alcohol#tab=tab_1
Alcohol-Use Disorders: Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence. National Collaborating Centre for Mental Health (UK). Leicester (UK): British Psychological Society; 2011.
Hammer J, Parent M, Spiker D. Global status report on alcohol and health 2018 65.1 (2018).. Global status report on alcohol. 2018;65(1).
World Health Organization. Alcohol. https://www.who.int/news-room/fact-sheets/detail/alcohol. Accessed 2018.
Mantzouranis G. Alcohol and narcotics use in inflammatory bowel disease. Annals of Gastroenterology. 2018;. https://doi.org/10.20524/aog.2018.0302
Bergmann MM, Hernandez V, Bernigau W, Boeing H, Chan SSM, Luben R, Khaw K, van Schaik F, Oldenburg B, Bueno-de-Mesquita B, Overvad K, Palli D, Masala G, Carbonnel F, Boutron-Ruault M, Olsen A, Tjonneland A, Kaaks R, Katzke V, Riboli E, Hart AR. No association of alcohol use and the risk of ulcerative colitis or Crohn’s disease: data from a European Prospective cohort study (EPIC). European Journal of Clinical Nutrition. 2017 Jan 25;71(4):512-518. https://doi.org/10.1038/ejcn.2016.271
Nie J, Zhao Q. Beverage consumption and risk of ulcerative colitis. Medicine. 2017 Dec;96(49):e9070. https://doi.org/10.1097/md.0000000000009070
Cohen AB, Lee D, Long MD, Kappelman MD, Martin CF, Sandler RS, Lewis JD. Dietary Patterns and Self-Reported Associations of Diet with Symptoms of Inflammatory Bowel Disease. Digestive Diseases and Sciences. 2012 Aug 26;58(5):1322-1328. https://doi.org/10.1007/s10620-012-2373-3
Swanson GR, Sedghi S, Farhadi A, Keshavarzian A. Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease. Alcohol. 2010 May;44(3):223-228. https://doi.org/10.1016/j.alcohol.2009.10.019
Rossi M, Anwar MJ, Usman A, Keshavarzian A, Bishehsari F. Colorectal Cancer and Alcohol Consumption—Populations to Molecules. Cancers. 2018 Jan 30;10(2):38. https://doi.org/10.3390/cancers10020038
Wang R, Leong R. Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: a review of the literature. World J Gastroenterol. 2014 Jul 21;20(27):8783-9. https://doi.org/10.3748/wjg.v20.i27.8783 PMID 25083052
Hagström H. Alcohol Consumption in Concomitant Liver Disease: How Much is Too Much?. Current Hepatology Reports. 2017 Apr 22;16(2):152-157. https://doi.org/10.1007/s11901-017-0343-0
Hagström H. Alcohol consumption in patients with primary sclerosing cholangitis. World Journal of Gastroenterology. 2012;18(24):3105. https://doi.org/10.3748/wjg.v18.i24.3105
Faure S, Herrero A, Jung B, Duny Y, Daures J, Mura T, Assenat E, Bismuth M, Bouyabrine H, Donnadieu-Rigole H, Navarro F, Jaber S, Larrey D, Pageaux G. Excessive alcohol consumption after liver transplantation impacts on long-term survival, whatever the primary indication. Journal of Hepatology. 2012 Aug;57(2):306-312. https://doi.org/10.1016/j.jhep.2012.03.014
Rice JP, Eickhoff J, Agni R, Ghufran A, Brahmbhatt R, Lucey MR. Abusive drinking after liver transplantation is associated with allograft loss and advanced allograft fibrosis. Liver Transplantation. 2013 Nov 27;19(12):1377-1386. https://doi.org/10.1002/lt.23762
Häuser W, Janke K, Klump B, Hinz A. Anxiety and depression in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 2011 Feb;17(2):621-632. https://doi.org/10.1002/ibd.21346
Kuźnicki P, Kempiński R, Neubauer K. The emerging role of mood disorders in inflammatory bowel diseases. Advances in Clinical and Experimental Medicine. 2020 Dec 31;29(12):1505-1510. https://doi.org/10.17219/acem/127676
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Copyright (c) 2021 The copyright to the submitted manuscript is held by the Author, who grants the Journal of Medical Science (JMS) a nonexclusive licence to use, reproduce, and distribute the work, including for commercial purposes.
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Accepted 2021-04-02
Published 2021-03-30
