Benefits of prenatal and postnatal vitamin D supplementation
DOI:
https://doi.org/10.20883/medical.e498Keywords:
vitamin D deficiency, supplementation in pregnancy, infants, neonatesAbstract
The best evidence for the role of vitamin D in infants is its influence on skeletal growth, however, the pleiotropic actions of vitamin D in the foetus and neonates are under-researched. The systematic reviews, based mostly on observational studies, suggest correlations between prenatal and postnatal supplementation and the occurrence of allergy, respiratory infections, sepsis or mental and behavioural development. Some of these studies focused on subgroups of neonates, such as preterm infants, investigating the influence inter alia on sepsis, bronchopulmonary dysplasia, and necrotising enterocolitis. Currently, there is a need for randomised trials for proof of the skeletal and pleiotropic effects of vitamin D in infants.
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Montecimo M. Biological and Molecular Effects of Vitamin D on Bone. In: Holick M, ed. Nutrition and Health. Vitamin D: Physiology, Molecular Biology, and Clinical Applications. 2nd edition. New York: Springer Science & Business Media; 2010:189-211, 651-669.
Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, Turck D, van Goudoever J. Vitamin D in the Healthy European Paediatric Population. Journal of Pediatric Gastroenterology & Nutrition. 2013 Jun;56(6):692-701. https://doi.org/10.1097/mpg.0b013e31828f3c05
Winzenberg T, Powell S, Shaw KA, Jones G. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ. 2011 Jan 25;342(jan25 1):c7254-c7254. https://doi.org/10.1136/bmj.c7254
Tan ML, Abrams SA, Osborn DA. Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health. . Cochrane Database of Systematic Reviews. 2020 Dec 11;. https://doi.org/10.1002/14651858.cd013046.pub2
Czech-Kowalska J. Osteopenia wcześniaków - algorytm postępowania. Klinika Pediatryczna. 2019;21:11-7.
Czech-Kowalska J. Vitamin D in preterm infants. In: Watson R, Mahadevan D, eds. Handbook of nutrition and diet in therapy of bone diseases. The Netherlands: Wageningen Academic Publishers; 2016:233-46.
Maugeri A, Barchitta M, Blanco I, Agodi A. Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2019 Feb 20;11(2):442. https://doi.org/10.3390/nu11020442
Tous M, Villalobos M, Iglesias L, Fernández-Barrés S, Arija V. Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies. European Journal of Clinical Nutrition. 2019 Jan 25;74(1):36-53. https://doi.org/10.1038/s41430-018-0373-x
McDonnell SL, Baggerly KA, Baggerly CA, Aliano JL, French CB, Baggerly LL, Ebeling MD, Rittenberg CS, Goodier CG, Mateus Niño JF, Wineland RJ, Newman RB, Hollis BW, Wagner CL. Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center. Rosenfeld CS. PLOS ONE. 2017 Jul 24;12(7):e0180483. https://doi.org/10.1371/journal.pone.0180483
Bärebring L, Bullarbo M, Glantz A, Hulthén L, Ellis J, Jagner Å, Schoenmakers I, Winkvist A, Augustin H. Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: a prospective cohort study. BMC Pregnancy and Childbirth. 2018 Feb 13;18(1). https://doi.org/10.1186/s12884-018-1683-7
Zhou S, Tao Y, Huang K, Zhu B, Tao F. Vitamin D and risk of preterm birth: Up-to-date meta-analysis of randomized controlled trials and observational studies. Journal of Obstetrics and Gynaecology Research. 2017 Feb;43(2):247-256. https://doi.org/10.1111/jog.13239
Fewtrell MS, Cole TJ, Bishop NJ, Lucas A. Neonatal factors predicting childhood height in preterm infants: Evidence for a persisting effect of early metabolic bone disease?. The Journal of Pediatrics. 2000 Nov;137(5):668-673. https://doi.org/10.1067/mpd.2000.108953
Balasuriya CND, Evensen KAI, Mosti MP, Brubakk A, Jacobsen GW, Indredavik MS, Schei B, Stunes AK, Syversen U. Peak Bone Mass and Bone Microarchitecture in Adults Born With Low Birth Weight Preterm or at Term: A Cohort Study. The Journal of Clinical Endocrinology & Metabolism. 2017 Apr 27;102(7):2491-2500. https://doi.org/10.1210/jc.2016-3827
Xie LF, Alos N, Cloutier A, Béland C, Dubois J, Nuyt AM, Luu TM. The long-term impact of very preterm birth on adult bone mineral density. Bone Reports. 2019 Jun;10:100189. https://doi.org/10.1016/j.bonr.2018.100189
Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. British Medical Bulletin. 2018 Apr 19;126(1):57-77. https://doi.org/10.1093/bmb/ldy010
Berdal A, Papagerakis P, Hotton D, Bailleul-Forestier I, Davideau J. Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review. Int J Dev Biol. 1995;31(1):257-62. PMID 7626415
Nørrisgaard PE, Haubek D, Kühnisch J, Chawes BL, Stokholm J, Bønnelykke K, Bisgaard H. Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring. JAMA Pediatrics. 2019 Oct 1;173(10):924. https://doi.org/10.1001/jamapediatrics.2019.2545
Schwalfenberg GK. A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency. Molecular Nutrition & Food Research. 2010 Sep 7;55(1):96-108. https://doi.org/10.1002/mnfr.201000174
Zipitis C, Akobeng A. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Archives of Disease in Childhood. 2008 Jun 1;93(6):512-517. https://doi.org/10.1136/adc.2007.128579
Hyppönen E, Läärä E, Reunanen A, Järvelin M, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. The Lancet. 2001 Nov;358(9292):1500-1503. https://doi.org/10.1016/s0140-6736(01)06580-1
Yepes-Nuñez JJ, Brożek JL, Fiocchi A, Pawankar R, Cuello-García C, Zhang Y, Morgano GP, Agarwal A, Gandhi S, Terracciano L, Schünemann HJ. Vitamin D supplementation in primary allergy prevention: Systematic review of randomized and non-randomized studies. Allergy. 2017 Aug 11;73(1):37-49. https://doi.org/10.1111/all.13241
Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J, Stokholm J, Bønnelykke K, Bisgaard H, Weiss ST. Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: A combined analysis of two randomized controlled trials. Cameron DW. PLOS ONE. 2017 Oct 27;12(10):e0186657. https://doi.org/10.1371/journal.pone.0186657
HYPPöNEN E, SOVIO U, WJST M, PATEL S, PEKKANEN J, HARTIKAINEN A, JäRVELINB M. Infant Vitamin D Supplementation and Allergic Conditions in Adulthood: Northern Finland Birth Cohort 1966. Annals of the New York Academy of Sciences. 2004 Dec;1037(1):84-95. https://doi.org/10.1196/annals.1337.013
Giannetti A, Bernardini L, Cangemi J, Gallucci M, Masetti R, Ricci G. Role of Vitamin D in Prevention of Food Allergy in Infants. Frontiers in Pediatrics. 2020 Aug 18;8. https://doi.org/10.3389/fped.2020.00447
Zisi D, Challa A, Makis A. The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood. Hormones. 2019 Nov 25;18(4):353-363. https://doi.org/10.1007/s42000-019-00155-z
Christensen N, Søndergaard J, Fisker N, Christesen HT. Infant Respiratory Tract Infections or Wheeze and Maternal Vitamin D in Pregnancy. Pediatric Infectious Disease Journal. 2017 Apr;36(4):384-391. https://doi.org/10.1097/inf.0000000000001452
Workneh Bitew Z, Worku T, Alemu A. Effects of vitamin D on neonatal sepsis: A systematic review and meta‐analysis. Food Science & Nutrition. 2020 Nov 10;9(1):375-388. https://doi.org/10.1002/fsn3.2003
Cetinkaya M, Erener-Ercan T, Kalayci-Oral T, Babayiğit A, Cebeci B, Semerci SY, Buyukkale G. Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?. Journal of Perinatology. 2017 Mar 23;37(6):673-678. https://doi.org/10.1038/jp.2017.18
Say B, Uras N, Sahin S, Degirmencioglu H, Oguz SS, Canpolat FE. Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants. Korean Journal of Pediatrics. 2017;60(8):248. https://doi.org/10.3345/kjp.2017.60.8.248
Park HW, Lim G, Park Y, Chang M, Son JS, Lee R. Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. Ehrhardt H. PLOS ONE. 2020 Jul 6;15(7):e0235332. https://doi.org/10.1371/journal.pone.0235332
Whitehouse AJO, Holt BJ, Serralha M, Holt PG, Kusel MMH, Hart PH. Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development. PEDIATRICS. 2012 Feb 13;129(3):485-493. https://doi.org/10.1542/peds.2011-2644
Morales E, Guxens M, Llop S, Rodriguez-Bernal CL, Tardon A, Riano I, Ibarluzea J, Lertxundi N, Espada M, Rodriguez A, Sunyer J. Circulating 25-Hydroxyvitamin D3 in Pregnancy and Infant Neuropsychological Development. PEDIATRICS. 2012 Sep 17;130(4):e913-e920. https://doi.org/10.1542/peds.2011-3289
Strøm M, Halldorsson TI, Hansen S, Granström C, Maslova E, Petersen SB, Cohen AS, Olsen SF. Vitamin D Measured in Maternal Serum and Offspring Neurodevelopmental Outcomes: A Prospective Study with Long-Term Follow-Up. Annals of Nutrition and Metabolism. 2014;64(3-4):254-261. https://doi.org/10.1159/000365030
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