Cervical expression of elafin and secretory leukocyte peptidase inhibitor does not predict preterm delivery in twin pregnancy – results from a pilot study

Aleksandra Saletra-Bielińska; Katarzyna Kosińska-Kaczyńska; Iwona Szymusik; Justyna Niderla-Bielińska; Jacek Malejczyk; Mirosław Wielgoś

doi:10.20883/medical.e490

Authors

Aleksandra Saletra-Bielińska 1st Department of Obstetrics and Gynecology, First Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland https://orcid.org/0000-0003-1802-3334
Katarzyna Kosińska-Kaczyńska Second Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education https://orcid.org/0000-0001-5461-273X
Iwona Szymusik 1st Department of Obstetrics and Gynecology, First Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland https://orcid.org/0000-0001-8106-5428
Justyna Niderla-Bielińska Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw https://orcid.org/0000-0002-9295-480X
Jacek Malejczyk Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw https://orcid.org/0000-0002-5371-8476
Mirosław Wielgoś 1st Department of Obstetrics and Gynecology, First Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland https://orcid.org/0000-0003-2581-3668

DOI:

https://doi.org/10.20883/medical.e490

Keywords:

twin pregnancy, elafin, secretory leukocyte peptidase inhibitor, preterm delivery

Abstract

Background. Elafin and secretory leukocyte peptidase inhibitor may serve as the predictors of cervical shortening and preterm delivery in twin gestation.

Material and Methods. A prospective observational study was conducted between September 2016 and March 2017. Cervicovaginal swabs collected from 40 women with twin gestation were analysed and the mRNA expression of elafin and secretory leukocyte peptidase inhibitor (SLPI) correlated with preterm delivery.

Results. The mean gestational age at delivery was 35.6 ± 5.8 weeks, with 23 women delivering before 37 weeks (57.5%), 7 before 34 weeks (17.5%) and 3 before 32 weeks of gestation (7.5%). The mRNA expression of elafin and SLPI was not dependent on chorionicity and did not correlate with gestational age at delivery.

Conclusions. Elafin and SLPI are not appropriate predictors of preterm delivery in twins.

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Author Biography

Katarzyna Kosińska-Kaczyńska, Second Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education

Assoc. Prof. Katarzyna Kosinska-Kaczynska, MD, PhD, Second Department of Obstetrics and Gynecology, Canter of Postgraduate Medical Education, Marymoncka St. 99/103, 01-813 Warsaw, Poland; phone: +48225690274; e-mail: katarzyna.kosinska-kaczynska@cmkp.edu.pl

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