The angiotensin converting enzyme inhibitors – alternative clinical applications

  • Beata Stanisz Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poland
  • Katarzyna Regulska Greater Poland Oncology Center
  • Miłosz Regulski Chair and Department of Toxicology, Poznan University of Medical Sciences, Poland
Keywords: renin-angiotensin system, off-label use, cancer


Angiotensin converting enzyme inhibitors have emerged as a useful strategy in the management of hypertension and other cardiovascular system-related diseases. However, a wide range of their biological effects has turned the scientific interest towards other possible clinical applications of these drugs. The present review demonstrates the available data on the reported angiotensin-converting enzyme inhibitors – based therapies in the treatment of the following human disturbances: cancer, obesity, Barrett syndrome, erythrocytosis, a high-dose-chemotherapy-induced cardiotoxicity, Marfan syndrome, Duchenne muscular dystrophy, migraine, Raynaud’s syndrome and Alzheimer disease.