The angiotensin converting enzyme inhibitors – alternative clinical applications
Chair and Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poland
Greater Poland Oncology Center
Chair and Department of Toxicology, Poznan University of Medical Sciences, Poland
renin-angiotensin system, off-label use, cancer
Angiotensin converting enzyme inhibitors have emerged as a useful strategy in the management of hypertension and other cardiovascular system-related diseases. However, a wide range of their biological effects has turned the scientific interest towards other possible clinical applications of these drugs. The present review demonstrates the available data on the reported angiotensin-converting enzyme inhibitors – based therapies in the treatment of the following human disturbances: cancer, obesity, Barrett syndrome, erythrocytosis, a high-dose-chemotherapy-induced cardiotoxicity, Marfan syndrome, Duchenne muscular dystrophy, migraine, Raynaud’s syndrome and Alzheimer disease.