The role of bisphenol A and its analogues as endocrine disruptors influencing the thyroid gland: a short review




bisphenol A, thyroid, hypothyroidism, endocrine disrupting chemical, plastic, autoimmunity


Bisphenols (BPs) are common plastic additives widely used in industry, hence, human exposure to BPs is inevitable. The best known BP is bisphenol A (BPA), the production of which and its analogues has been increasing worldwide. This chemical is classified as an endocrine-disrupting chemical, inferring with hormonal homeostasis. Indeed, BPA is associated with the development of oestrogen-dependent neoplasms, infertility, metabolic disorders and neurobehavioral disturbances. However, there is a lack of evidence regarding the impact of BPA and its analogues on the thyroid, with most studies mainly performed on animals or in vitro. This review aims to summarise the knowledge regarding the relationship between BPA and its analogues on the thyroid gland.


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Braun JM, Hauser R. Bisphenol A and childrenʼs health. Current Opinion in Pediatrics. 2011 Apr;23(2):233-239.

Carwile JL, Luu HT, Bassett LS, Driscoll DA, Yuan C, Chang JY, Ye X, Calafat AM, Michels KB. Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations. Environmental Health Perspectives. 2009 Sep;117(9):1368-1372.

Fenichel P, Chevalier N, Brucker-Davis F. Bisphenol A: An endocrine and metabolic disruptor. Annales d'Endocrinologie. 2013 Jul;74(3):211-220.

Geens T, Goeyens L, Kannan K, Neels H, Covaci A. Levels of bisphenol-A in thermal paper receipts from Belgium and estimation of human exposure. Science of The Total Environment. 2012 Oct;435-436:30-33.

Hehn RS. NHANES Data Support Link between Handling of Thermal Paper Receipts and Increased Urinary Bisphenol A Excretion. Environmental Science & Technology. 2015 Dec 17;50(1):397-404.

Rubin BS. Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects. The Journal of Steroid Biochemistry and Molecular Biology. 2011 Oct;127(1-2):27-34.

Geens T, Aerts D, Berthot C, Bourguignon J, Goeyens L, Lecomte P, Maghuin-Rogister G, Pironnet A, Pussemier L, Scippo M, Van Loco J, Covaci A. A review of dietary and non-dietary exposure to bisphenol-A. Food and Chemical Toxicology. 2012 Oct;50(10):3725-3740.

Vandenberg LN, Chahoud I, Heindel JJ, Padmanabhan V, Paumgartten FJ, Schoenfelder G. Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A. Environmental Health Perspectives. 2010 Aug;118(8):1055-1070.

La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, Guyton KZ, Kortenkamp A, Cogliano VJ, Woodruff TJ, Rieswijk L, Sone H, Korach KS, Gore AC, Zeise L, Zoeller RT. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nature Reviews Endocrinology. 2019 Nov 12;16(1):45-57.

Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Vom Saal FS. Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society. Endocrinology. 2012 Sep 1;153(9):4097-4110.

Rutkowska A, Rachoń D, Milewicz A, Ruchała M, Bolanowski M, Jędrzejuk D, Bednarczuk T, Górska M, Hubalewska-Dydejczyk A, Kos-Kudła B, Lewiński A, Zgliczyński W. Polish Society of Endocrinology Position statement on endocrine disrupting chemicals (EDCs). Endokrynologia Polska. 2015;66(3):276-85.

Konduracka E, Krzemieniecki K, Gajos G. Relationship between everyday use cosmetics and female breast cancer. Polish Archives of Internal Medicine. 2014 Apr 2;124(5):264-269.

López-Carrillo L, Hernández-Ramírez RU, Calafat AM, Torres-Sánchez L, Galván-Portillo M, Needham LL, Ruiz-Ramos R, Cebrián ME. Exposure to Phthalates and Breast Cancer Risk in Northern Mexico. Environmental Health Perspectives. 2010 Apr;118(4):539-544.

Rutkowska AZ, Szybiak A, Serkies K, Rachoń D. Endocrine disrupting chemicals as the potential risk factor for estrogen-dependent cancers. Polish Archives of Internal Medicine. 2016 Aug 9;.

Mantzouki C, Bliatka D, Iliadou PK, Margeli A, Papassotiriou I, Mastorakos G, Kousta E, Goulis DG. Serum Bisphenol A concentrations in men with idiopathic infertility. Food and Chemical Toxicology. 2019 Mar;125:562-565.

Konieczna A, Rachoń D, Owczarek K, Kubica P, Kowalewska A, Kudłak B, Wasik A, Namieśnik J. Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome. Reproductive Toxicology. 2018 Dec;82:32-37.

Wassenaar PNH, Trasande L, Legler J. Systematic Review and Meta-Analysis of Early-Life Exposure to Bisphenol A and Obesity-Related Outcomes in Rodents. Environmental Health Perspectives. 2017 Oct 3;125(10):106001.

Perera F, Nolte EL, Wang Y, Margolis AE, Calafat AM, Wang S, Garcia W, Hoepner LA, Peterson BS, Rauh V, Herbstman J. Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10–12 years of age. Environmental Research. 2016 Nov;151:195-202.

Kitamura S. Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds. Toxicological Sciences. 2005 Jan 19;84(2):249-259.

Chevrier J, Gunier RB, Bradman A, Holland NT, Calafat AM, Eskenazi B, Harley KG. Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study. Environmental Health Perspectives. 2013 Jan;121(1):138-144.

Moriyama K, Tagami T, Akamizu T, Usui T, Saijo M, Kanamoto N, Hataya Y, Shimatsu A, Kuzuya H, Nakao K. Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist. The Journal of Clinical Endocrinology & Metabolism. 2002 Nov 1;87(11):5185-5190.

Lee S, Kim C, Youn H, Choi K. Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Toxicology in Vitro. 2017 Apr;40:297-304.

Lee J, Kim S, Choi K, Ji K. Effects of bisphenol analogs on thyroid endocrine system and possible interaction with 17β-estradiol using GH3 cells. Toxicology in Vitro. 2018 Dec;53:107-113.

Higashihara N, Shiraishi K, Miyata K, Oshima Y, Minobe Y, Yamasaki K. Subacute oral toxicity study of bisphenol F based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”. Archives of Toxicology. 2007 Jul 13;81(12):825-832.

Zoeller RT, Bansal R, Parris C. Bisphenol-A, an Environmental Contaminant that Acts as a Thyroid Hormone Receptor Antagonist in Vitro, Increases Serum Thyroxine, and Alters RC3/Neurogranin Expression in the Developing Rat Brain. Endocrinology. 2005 Feb 1;146(2):607-612.

Lee S, Kim C, Shin H, Kho Y, Choi K. Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish. Chemosphere. 2019 Apr;221:115-123.

Völkel W, Colnot T, Csanády GA, Filser JG, Dekant W. Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration. Chemical Research in Toxicology. 2002 Oct;15(10):1281-1287.

Andrianou XD, Gängler S, Piciu A, Charisiadis P, Zira C, Aristidou K, Piciu D, Hauser R, Makris KC. Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function. Carvalho DPD. PLOS ONE. 2016 Oct 26;11(10):e0155237.

Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL. Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population. Environmental Health Perspectives. 2005 Apr;113(4):391-395.

Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reproductive Toxicology. 2007 Aug;24(2):139-177.

Schmutzler C, Bacinski A, Gotthardt I, Huhne K, Ambrugger P, Klammer H, Schlecht C, Hoang-Vu C, Grüters A, Wuttke W, Jarry H, Köhrle J. The Ultraviolet Filter Benzophenone 2 Interferes with the Thyroid Hormone Axis in Rats and Is a Potent in Vitro Inhibitor of Human Recombinant Thyroid Peroxidase. Endocrinology. 2007 Jun 1;148(6):2835-2844.

Kudo Y. In Vitro and in Vivo Analysis of the Thyroid Disrupting Activities of Phenolic and Phenol Compounds in Xenopus laevis. Toxicological Sciences. 2005 Jan 5;84(1):29-37.

Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neuroscience Research. 2007 Jun;58(2):149-155.

Nieminen P, Lindström-Seppä P, Juntunen M, Asikainen J, Mustonen A, Karonen S, Mussalo-Rauhamaa H, Kukkonen J. In vivo effects of bisphenol A on the polecat (mustela putorius). Journal of Toxicology and Environmental Health. Part A. 2002;65:933-45.

Aung MT, Johns LE, Ferguson KK, Mukherjee B, McElrath TF, Meeker JD. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environment International. 2017 Jul;104:33-40.

Romano ME, Webster GM, Vuong AM, Thomas Zoeller R, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: The HOME Study. Environmental Research. 2015 Apr;138:453-460.

Meeker JD, Ferguson KK. Relationship between Urinary Phthalate and Bisphenol A Concentrations and Serum Thyroid Measures in U.S. Adults and Adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007–2008. Environmental Health Perspectives. 2011 Oct;119(10):1396-1402.

Geens T, Dirtu AC, Dirinck E, Malarvannan G, Van Gaal L, Jorens PG, Covaci A. Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals. Environment International. 2015 Mar;76:98-105.

Minatoya M, Sasaki S, Araki A, Miyashita C, Itoh S, Yamamoto J, Matsumura T, Mitsui T, Moriya K, Cho K, Morioka K, Minakami H, Shinohara N, Kishi R. Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates. Epidemiology. 2017 Oct;28:S3-S9.

Derwahl M, Nicula D. Estrogen and its role in thyroid cancer. Endocrine Related Cancer. 2014 Jul 22;21(5):T273-T283.

Klinge. Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors α and β. International Journal of Oncology. 2010 Mar 24;36(5).

Liu J, Chen G, Meng X, Liu Z, Dong S. Serum levels of sex hormones and expression of their receptors in thyroid tissue in female patients with various types of thyroid neoplasms. Pathology - Research and Practice. 2014 Dec;210(12):830-835.

Zhou Z, Zhang J, Jiang F, Xie Y, Zhang X, Jiang L. Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. Bioscience Reports. 2017 Jul 27;37(4).

Marotta V, Russo G, Gambardella C, Grasso M, La Sala D, Chiofalo MG, D'Anna R, Puzziello A, Docimo G, Masone S, Barbato F, Colao A, Faggiano A, Grumetto L. Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules. Chemosphere. 2019 Mar;218:885-894.

Li L, Ying Y, Zhang C, Wang W, Li Y, Feng Y, Liang J, Song H, Wang Y. Bisphenol A exposure and risk of thyroid nodules in Chinese women: A case-control study. Environment International. 2019 May;126:321-328.

Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q, Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. Gao C. PLOS ONE. 2015 Oct 23;10(10):e0141248.

Chailurkit L, Aekplakorn W, Ongphiphadhanakul B. The Association of Serum Bisphenol A with Thyroid Autoimmunity. International Journal of Environmental Research and Public Health. 2016 Nov 17;13(11):1153.

Özaydın T, Öznurlu Y, Sur E, Çelik İ, Uluışık D. The effects of bisphenol A on some plasma cytokine levels and distribution of CD8+ and CD4+ T lymphocytes in spleen, ileal Peyer’s patch and bronchus associated lymphoid tissue in rats. Acta Histochemica. 2018 Nov;120(8):728-733.

Aljadeff G, Longhi E, Shoenfeld Y. Bisphenol A: A notorious player in the mosaic of autoimmunity. Autoimmunity. 2018 Nov 17;51(8):370-377.

Kharrazian D. The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity. Autoimmune Diseases. 2014;2014:1-12.

Jensen CD, Andersen KE. Two cases of occupational allergic contact dermatitis from a cycloaliphatic epoxy resin in a neat oil: Case Report. Environmental Health. 2003 Mar 26;2(1).

Hannu T, Frilander H, Kauppi P, Kuuliala O, Alanko K. IgE-Mediated Occupational Asthma from Epoxy Resin. International Archives of Allergy and Immunology. 2009;148(1):41-44.




How to Cite

Milczarek-Banach J, Miśkiewicz P. The role of bisphenol A and its analogues as endocrine disruptors influencing the thyroid gland: a short review. JMS [Internet]. 2020 Sep. 30 [cited 2023 Dec. 11];89(3):e441. Available from:



Review Papers
Received 2020-06-12
Accepted 2020-07-31
Published 2020-09-30