Published: 2020-07-28

The role of STAT3 in the colorectal cancer therapy : Running title: STAT3 in colorectal cancer

Poznan University of Medical Sciences, Department of Pharmaceutical Biochemistry
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences
STAT3, colorectal cancer, kinase JAK, SOCS proteins

Abstract

Colorectal cancer is a type of a malignant tumor in the digestive system and its incidence rate in the United States and the European Union increases by an average of 4.2% to 4.6% annually. Colorectal cancer is a common tumor affecting rather elderly than younger individuals. An increasing number of studies prove that deregulation of the signaling pathway and abnormal expression and activation of genes can be the main reason for the development of colorectal cancer. Signal transducer and activator of transcription (STAT3) is a transcription factor of signal transduction and transcriptional activation of target genes and plays important roles in proliferation, differentiation apoptosis and other physiological processes. Several data confirm that abnormal activation of STAT3 is involved in the development of tumors. Identifying compounds that inhibit STAT3 is a promising strategy for cancer chemoprevention and treatment of colorectal cancer. In this review, the roles of STAT3 in pathogenesis and treatment of colorectal cancer are discussed.

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How to Cite

1.
Krajka-Kuźniak V, Papierska K. The role of STAT3 in the colorectal cancer therapy : Running title: STAT3 in colorectal cancer. JMS [Internet]. 2020Jul.28 [cited 2020Aug.11];. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/427