Effect of vitamin K supplementation on anthropometric parameters and adipokine levels – a systematic review

Vitamin K and anthropometric parameters

Authors

DOI:

https://doi.org/10.20883/medical.402

Keywords:

vitamin K, dietary supplements, body weight, leptin, adiponectin

Abstract

Aim. The aim of this systematic review was to assess the effect of vitamin K supplementation on anthropometric parameters and adipokine levels in adults.
Material and Methods. Four databases (PubMed, Web of Sciences, Scopus and the Cochrane Library) were searched to select studies in which the effect of vitamin K supplementation on body weight, body mass index (BMI), fat mass, leptin and adiponectin levels were assessed.
Results. We identified nine studies that included a total of 542 subjects. Vitamin K supplementation did not influence body weight, BMI and percentage of fat mass. In addition, the effect of vitamin K supplementation on adipokines levels was equivocal.
Conclusions. Vitamin K supplementation did not affect anthropometric parameters and adipokines levels. Nevertheless, further studies are needed to clarify the effect of vitamin K supplementation on these parameters in adults.

Downloads

Download data is not yet available.

References

Schurgers LJ, Vermeer C. Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis. 2000 Nov‑Dec;30(6):298–307.

Bolton‑Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJ. Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr. 2000 Apr;83(4):389–399.

Cranenburg ECM, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost. 2007 Jul;98(1):120–125.

Booth SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, McLean RR, et al. Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr. 2003 Feb;77(2):512–516.

Dam V, Dalmeijer GW, Vermeer C, Drummen NE, Knapen MH, van der Schouw YT, et al. Association between vitamin K and the metabolic syndrome: a 10-year follow‑up study in adults. J Clin Endocrinol Metab. 2015 Jun;100(6):2472–2479.

Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, et al. Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the health, aging, and body composition study (Health ABC). J Nutr. 2017 May;147(5):888–895.

Sakamoto N, Nishiike T, Iguchi H, Sakamoto K. Relationship between acute insulin response and vitamin K intake in healthy young male volunteers. Diabetes Nutr Metab. 1999 Feb;12(1):37–41.

Yoshida M, Booth SL, Meigs JB, Saltzman E, Jacques PF. Phylloquinone intake, insulin sensitivity, and glycemic status in men and women. Am J Clin Nutr. 2008 Jul;88(1):210–215.

Yoshida M, Jacques PF, Meigs JB, Saltzman E, Shea MK, Gundberg C, et al. Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care. 2008 Nov;31(11):2092–2096.

Mazzanti L, Battino M, Nanetti L, Raffaelli F, Alidori A, Sforza G, et al. Effect of 1-year dietary supplementation with vitaminized olive oil on markers of bone turnover and oxidative stress in healthy post‑menopausal women. Endocrine. 2015 Nov;50(2):326–334.

Erkkilä AT, Booth SL, Hu FB, Jacques PF, Manson JE, Rexrode KM, et al. Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. Eur J Clin Nutr. 2005 Feb;59(2):196–204.

Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MHJ, van der Meeret IM, al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100–3105.

Braam L, McKeown N, Jacques P, Lichtenstein A, Vermeer C, Wilson P, et al. Dietary phylloquinone intake as a potential marker for a heart‑healthy dietary pattern in the Framingham Offspring cohort. J Am Diet Assoc. 2004 Sep;104(9):1410–1414.

Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, et al. Low‑dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. J Bone Miner Metab. 2014 Mar;32(2):142–150.

Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, et al. Effect of low dose vitamin K2 (MK-4) supplementation on bio‑indices in postmenopausal Japanese women. J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15–21.

Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB, Dawson‑Hughes B, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb;167(3):313–320.

Lee B‑C, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity‑induced insulin resistance. Biochim Biophys Acta. 2014 Mar;1842(3):446–462.

Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011 Jun;121(6):2111–2117.

Sogabe N, Maruyama R, Baba O, Hosoi T, Goseki‑Sone M. Effects of long‑term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. Bone. 2011 May;48(5):1036–1042.

Knapen MHJ, Schurgers LJ, Shearer MJ, Newman P, Theuwissen E, Vermeer C. Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. Br J Nutr. 2012 Sep;108(6):1017–1024.

Shea MK, Dawson‑Hughes B, Gundberg CM, Booth SL. Reducing undercarboxylated osteocalcin with vitamin K supplementation does not promote lean tissue Loss or fat gain over 3 years in older women and men: a randomized controlled trial. J Bone Miner Res. 2017 Feb;32(2):243–249.

Jamka M, Walach H, Walkowiak J. Effect of vitamin K supplementation on cardio‑metabolic parameters in adults. Prospero: CRD42017079368. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID = 79368. Published 2017. Accessed November 28, 2017.

Kmet LM, Lee RC, Cook LS. Standard quality assesment criteria for evaluating primary research papers from a variety of fields. Edmonton: Alberta Heritage Foundation for Medical Research; 2004.

Fulton RL, McMurdo MET, Hill A, Abboud RJ, Arnold GP, Struthers AD, et al. Effect of vitamin K on vascular health and physical function in older people with vascular disease — a randomised controlled trial. J Nutr Health Aging. 2016 Mar;20(3):325–333.

Rasekhi H, Karandish M, Jalali MT, et al. The effect of vitamin K1 supplementation on sensitivity and insulin resistance via osteocalcin in prediabetic women: a double‑blind randomized controlled clinical trial. Eur J Clin Nutr. 2015 Aug;69(8):891–895.

Rasekhi H, Karandish M, Jalali M‑T, Mohammad‑Shahi M, Zarei M, Saki A, et al. Phylloquinone supplementation improves glycemic status independent of the effects of adiponectin levels in premonopause women with prediabetes: a double‑blind randomized controlled clinical trial. J Diabetes Metab Disord. 2015 Aug;14(1):1.

Nakamura E, Aoki M, Watanabe F, Kamimura A. Low‑dose menaquinone-4 improves γ‑carboxylation of osteocalcin in young males: a non‑placebo‑controlled dose‑response study. Nutr J. 2014 Aug;13(1):85.

Dalmeijer GW, van der Schouw YT, Magdeleyns E, Ahmed N, Vermeer C, Beulens JWJ. The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis. 2012 Dec;225(2):397–402.

Volpe SL, Leung MM, Giordano H. Vitamin K supplementation does not significantly impact bone mineral density and biochemical markers of bone in pre- and perimenopausal women. Nutr Res. 2008 Sep;28(9):577–582.

Food and Nutrition Board. Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC): National Academies Press (US); 2001.

Booth SL, Lichtenstein AH, O’Brien‑Morse M, McKeown NM, Wood RJ, Saltzman E, et al. Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr. 2001 Dec;74(6):783–790.

Je SH, Joo N‑S, Choi B, Kim K‑M, Kim B‑T, Park S‑B, et al. Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty‑years‑old. J Korean Med Sci. 2011 Aug;26(8):1093–1098.

Binkley NC, Krueger DC, Engelke JA, Foley AL, Suttie JW. Vitamin K supplementation reduces serum concentrations of under‑gamma‑carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr. 2000 Dec;72(6):1523–1528.

Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007 Aug;130(3):456–469.

Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild‑type mice. Proc Natl Acad Sci U S A. 2008 Apr;105(13):5266–5270.

Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino Sr RB, et al. Genetic and non‑genetic correlates of vitamins K and D. Eur J Clin Nutr. 2009 Apr;63:458–464.

Takeuchi Y, Suzawa M, Fukumoto S, Fujita T. Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone. 2000 Dec;27(6):769–776.

Fisher A, Srikusalanukul W, Davis M, Smith P. Interactions between serum adipokines and osteocalcin in older patients with hip fracture. Int J Endocrinol. 2012;2012:684323.

Kindblom JM, Ohlsson C, Ljunggren Ö, Karlsson MK, Tivesten A, Smith U, et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res. 2009 May;24(5):785–791.

Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2009 Jan;94(1):45–49.

Reinehr T, Roth CL. A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes (Lond). 2010 May;34(5):852–858.

Suksomboon N, Poolsup N, Darli Ko Ko H. Effect of vitamin K supplementation on insulin sensitivity: a meta‑analysis. Diabetes, Metab Syndr Obes Targets Ther. 2017 May;10:169–177.

Rees K, Guraewal S, Wong YL, Majanbu DL, Mavrodaris A, Stranges S, et al. Is vitamin K consumption associated with cardio‑metabolic disorders? A systematic review. Maturitas. 2010 Oct;67(2):121–128.

Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost. 2008 Oct;100(4):530–547.

Schurgers LJ, Vermeer C. Differential lipoprotein transport pathways of K‑vitamins in healthy subjects. Biochim Biophys Acta. 2002 Feb;1570(1):27–32.

Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov;11(1):93.

Groenen‑van Dooren MM, Ronden JE, Soute BA, Vermeer C. Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K‑deficient rats. Biochem Pharmacol. 1995 Sep;50(6):797–801.

Sato T, Ohtani Y, Yamada Y, Saitoh S, Harada H. Difference in the metabolism of vitamin K between liver and bone in vitamin K‑deficient rats. Br J Nutr. 2002 Apr;87(4):307–314.

Schurgers LJ, Teunissen KJF, Hamulyák K, Knapen MHJ, Vik H, Vermeer C. Vitamin K‑containing dietary supplements: comparison of synthetic vitamin K1 and natto‑derived menaquinone-7. Blood. 2007 Apr;109(8):3279–3283.

Booth SL, Martini L, Peterson JW, Saltzman E, Dallal GE, Wood RJ. Dietary phylloquinone depletion and repletion in older women. J Nutr. 2003 Aug;133(8):2565–2569.

Vitamin K — NHS Choices. http://www.nhs.uk/Conditions/vitamins‑minerals/Pages/Vitamin‑K.aspx. Accessed August 12, 2017.

Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T. Vitamin K status of healthy Japanese women: age‑related vitamin K requirement for gamma‑carboxylation of osteocalcin. Am J Clin Nutr. 2006 Feb;83(2):380–386.

Walach H, Loef M. Using a matrix‑analytical approach to synthesizing evidence solved incompatibility problem in the hierarchy of evidence. J Clin Epidemiol. 2015 Nov;68(11):1251–1260.

Verma H, Garg R. Effect of vitamin K supplementation on cardiometabolic risk factors: a systematic review and meta‑analysis. Endocr Metab Immune Disord Drug Targets. 2019;19(1):13–25.

Downloads

Published

2019-12-12

How to Cite

1.
Jamka M, Walach H, Hołubiec M, Wasiewicz M, Walkowiak J. Effect of vitamin K supplementation on anthropometric parameters and adipokine levels – a systematic review: Vitamin K and anthropometric parameters. JMS [Internet]. 2019 Dec. 12 [cited 2024 Apr. 23];88(4):244-55. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/402

Issue

Section

Review Papers
Received 2020-01-07
Accepted 2020-01-19
Published 2019-12-12