Soluble selectins and highly fucosylated ?1-antichymotrypsin in rheumatoid arthritis patients

  • Anna Olewicz-Gawlik Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Izabela Korczowska-Łącka Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Paweł Hrycaj Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poland
Keywords: acute phase proteins, fucosylation, rheumatoid arthritis, selectins

Abstract

Introduction. Fucosylation of acute phase proteins and serum soluble selectin levels is increased in rheumatoid arthritis (RA) patients and can influence leukocyte extravasation. Aim. The aim of this study was to evaluate the concentration and fucosylation of ?1-antichymotrypsin (ACT) in relation to serum concentrations of soluble forms of selectins in RA patients. Material and methods. Serum samples of 70 RA patients and 30 healthy controls were examined using sandwich enzyme-linked immunosorbent assay (ELISA). Results. ACT-FR was significantly increased in RA patients when compared to healthy controls (p < 0.001) and significantly correlated with serum concentrations of rheumatoid factor (RF) and antibodies against cyclic citrullinated peptides (ACPA) (p = 0.006, p = 0.04, respectively). Moreover, we found significant correlations between the serum levels of soluble (s)P- and sE-selectin and ACT-FR (p = 0.008 and p = 0.03, respectively) only in male RA patients.Conclusions. Fucosylation of ACT differs between male and female RA patients and is related to sP- and sE-selectin levels only in men.