Histological evaluation of kidney development in young rats after a surgery and management of wound with fibrin glue

  • Dariusz Pańczyszyn Department of Immunobiochemistry Chair of Biology and Environmental Sciences, Poznan University of Medical Sciences, Poland
  • Paweł Kroll St. Joseph Poznan, Poland
  • Joanna Jagielska Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences
  • Piotr Tabaczewski Chair of Biology and Environmental Sciences, Poznan University of Medical Sciences, Poland
  • Marcin Grochowalski Department of General and Colorectal Surgery, Poznan University of Medical Sciences
  • Jakub Żurawski Department of Immunobiochemistry Chair of Biology and Environmental Sciences, Poznan University of Medical Sciences, Poland
Keywords: kidney, histology, surgery

Abstract

Aim. The subject of this study is evaluation of histological hallmarks of kidney growth in rats after a surgery and subsequent management of the wound with fibrin glue. Material and Methods. Sixty-five Wistar rats underwent a surgical procedure resulting in parenchymal injury by incision followed by an application of fibrin glue. Kidneys have been examined and evaluated histologically after 4 weeks (group I) and 26 weeks (group II) after the surgery Results. When fibrin glue was used, in both groups, regular anastomoses of the wound edges of the kidney after surgery were noted. Histological features of kidney growth (renal glomeruli, renal tubules and blood vessels) were observed in the parenchyma and in the postoperative scar. In the second group kidneys grew on average by 3.5mm in the longitudinal section and by 1.89 in the cross section. In this group, the number of renal glomeruli nearly doubled. Glomeruli and tubules were also found in the postoperative scar.