AbstractPolyunsaturated fatty acids (PUFAs) beneficially affect an optimal fetal growth and development right after birth. This effect is particularly significant for the growth and maturation of brain. Therefore, an appropriate maternal regimens for PUFAs supplementation, during pregnancy and lactation, may influence birth outcome and infant health. Recently, it has been shown that genetic profile is an another factor determining long-chain polyunsaturated fatty acids (LC-PUFA) composition in human tissues. Single Nucleotide Polymorphisms (SNPs) in the fatty desaturase 1 and 2 (FADS1 and FADS2) modify endogenous synthesis of PUFAs indicating that PUFAs blood concentration may depend on genetic background. What is more, a number of studies indicate that maternal FADS gene variants by their influence on LC-PUFAs synthesis are associated with child’s health right after birth as well as within first years of life. Determining individual dietary recommendations for clinical practice can be beneficial for both mother and the child.
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- Vadivelan G, Prabhakara Rao P, Venkateswaran G. Influence of Supplementation of Vegetable Oil Blends on Omega-3 Fatty Acid Production in Mortierella alpina CFR-GV15. BioMed Research International. 2017.
- Lauritzen L, Brambilla P, Mazzocchi A, et al. DHA Effects in Brain Development and Function. Nutrients. 2016 Jan;8(1):6.
- Harslof L, Larsen L, Ritz C, et al. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. Am J Clin Nutr. 2013 Jun;97(6):1403–1410.
- Bokor S, Dumont J, Spinneker A, et al. Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. J Lipid Res. 2010 Aug;51(8):2325–33.
- Wik Markhus M, Rasinger J, Kjellevold Malde M, et al. Docosahexaenoic Acid Status in Pregnancy Determines the Maternal Docosahexaenoic Acid Status 3-, 6- and 12 Months Postpartum. Results from a Longitudinal Observational Study. PLoS One. 2015; 10(9):e0136409.
- Lattka E, Klopp N, Demmelmair H, Klingler M, Heinrich J, Koletzko B. Genetic variations in polyunsaturated fatty acid metabolism--implications for child health? Ann Nutr Metab. 2012; 60 Suppl 3:8–17.
- Steer C, JR H, Golding J, Smith G. Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. Hum Mol Genet. 2012 Jul;21(7):1504–1512.
- Koletzko B, Lattka E, Zeilinger S, Illig T, C Steer C. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2011 Jan;93(1):211–219.
- Xie L, Innis S. Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n-6) and (n-3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation. J. Nutr. 2008 Nov;138(11):2222–2228.
- Bojarowicz H, Woźniak B. Polyunsaturated fatty acids and their influence on skin condition. Probl Hig Epidemiol. 2008; 89(4):471–475.
- Lewis N, Seburg S, Flanagan N. Enriched Eggs as a Source of n-3 Polyunsaturated Fatty Acids for Humans. Poult Sci. 2000 Jul;79(7):971–974.
- Doughman S, Krupanidhi S, Sanjeevi C. DHA-Rich Algae Oil Is a Safe and Effective Vegetarian Source of Omega-3. Omega-3 Fatty Acids. 2016 Sep:263–266.
- Heaton A, Meldrum S, Foster J, Prescott S, Simmer K. Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? Front Hum Neurosci. 2013 Jul:774.
- Morales E, Bustamante M, Gonzalez J, et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS One. 2011 Feb;6(2):e17181.
- Kawabata T, Kagawa Y, Kimura F, et al. Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth. Nutrients. 2017 Mar;9(3):245.
- Hibbeln J, Davis J, Steer C, et al. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet. 2007 Feb;369(9561):578–85.
- Yeates A, Love T, Engström K, et al. Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study. Prostaglandins Leukot Essent Fatty Acids. 2015 Dec:13–20.
- Moltó-Puigmartí C, van Dongen M, Dagnelie P, et al. Maternal but not fetal FADS gene variants modify the association between maternal long-chain PUFA intake in pregnancy and birth weight. J Nutr. 2014 Sep;144(9):1430–7.
- Gonzalez-Casanova I, Rzehak P, Stein A, et al. Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight. Am J Clin Nutr. 2016 Apr;103(4):1171–1178.
- Yelland L, Gajewski B, Colombo J, Gibson R, Makrides M, Carlson S. Predicting the effect of maternal docosahexaenoic acid (DHA) supplementation to reduce early preterm birth in Australia and the United States using results of within country randomized controlled trials. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016:44–49.
- Czajkowski K, Czerwionka- Szaflarska M. The position of Polish experts group concerning supplementation of DHA and the other omega-3 fatty acids in pregnant women, breast-feeding women, infants and small children. Pediatria Polska. 2010 Nov; p. 597–603.
- Jensen C, Voigt R, Prager T, et al. Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. Am J Clin Nutr. 2005 Jul;82(1):125–132.
- Colombo J, Gustafson K, Gajewski B, et al. Prenatal DHA Supplementation and Infant Attention. Pediatric Research. 2016 Jun;80(5):656–662.
- Scholtz S, Kerling E, Shaddy D, et al. Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy. Prostaglandins Leukot Essent Fatty Acids. 2015 Mar:29–33.
- Smithers L, Gibson R, McPhee A, Makrides M. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr. 2008 Oct;88(4):1049–1056.
- Furuhjelm C, Jenmalm M, Fälth-Magnusson K, Duchén K. Th1 and Th2 Chemokines, Vaccine-Induced Immunity, and Allergic Disease in Infants After Maternal ?-3 Fatty Acid Supplementation During Pregnancy and Lactation. Pediatric Research. 2011;69:259–264.
- Rzehak P, Thijs C, Standl M, et al. Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life. PLoS One. 2010 Oct;5(10):e13261.
- Barman M, Nilsson S, Torinsson Naluai A, Sandin A, Wold A, Sandberg A. Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort). Nutrients. 2015 Dec;7(12):10100–10115.
- Steer C, Lattka E, Koletzko B, Golding J, Hibbeln J. Maternal fatty acids in pregnancy, FADS polymorphisms, and child intelligence quotient at 8 y of age. Am J Clin Nutr. 2013 Dec;98(6):1575–82.
- Helland I, Smith L, Saarem K, Saugstad O, Drevon C. Maternal Supplementation With Very-Long-Chain n-3 Fatty Acids During Pregnancy and Lactation Augments Children's IQ at 4 Years of Age. Pediatrics. 2003 Feb;111(1):e39–44.
- Socha P. DHA supplementation in critical periods of life- how to implement Polish and International guidelines. Standardy Medyczne. 2013;10:521–526.