Thixotropic effect of some biochemical factors in ischaemic stroke


  • Piotr Kowal Rheological Laboratory, Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego 49, Poznań, POLAND
  • Anna Marcinkowska-Gapinska Rheological Laboratory, Department of Neurology, Poznan University of Medical Sciences, Przybyszewskiego 49, Poznań, POLAND



hemorheology, blood viscosity, plasma viscosity, blood proteins


Background. Yield shear stress (YSS) well characterizes the thixotropic status of blood, that exemplifies a reversible loss of blood fluidity due to a low shear rate. At the stable haematocrit ratio YSS depends mainly on the fibrinogen level.
Aim. Since the role of other biochemical factors in the YSS phenomenon in cerebral ischaemia has not been well known, we have undertaken this problem in a group of stroke patients.
Material and Methods. The study was carried out in 36 patients with acute ischaemic stroke and in 12 controls. YSS was estimated by means of microviscometric method. In all subjects the concentration of the following biochemical factors were assayed: albumin, IgG, IgA, IgM, apolipoprotein A, and B, cholesterol, triglycerides, LDL, HDL and fibrinogen. Then the thixotroipic effect of all biochemical factors and their correlations to fibrinogen were estimated by means of mathematical formulas.
Results. We found a positive correlation in relation to the following thixotropic effects: for all subjects and separately for patients’ group: Alb(YSS) (p < 0.001), ApoA(YSS) (p < 0.001), ApoB(YSS) (p < 0.05), chol(YSS) (p < 0.01), HDL(YSS) (p < 0.05); for patients group without additional diseases: Alb(YSS) (p < 0.05), ApoA(YSS) (p < 0.005), chol(YSS) (p < 0.05), HDL(YSS) (p < 0.02), LDL(YSS) (p < 0.05). There were not any significant correlations in controls.
Conclusions. Results of the study indicated that in the interaction between the red cells and fibrinogen some additional factors appearing or activating during ischaemic process may play a role.


Download data is not yet available.


Chien S. Rheology in the Microcirculation. In: Liss AR (ed.). Normal and Low Flow States. Adv Shock Reasearch. 1982;8:71–80.

Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. Handbook of Hemorheology and Hemodynamics. IOS Press Amsterdam, Berlin, Oxford, Tokyo, Washington, DC, 2007.

Marcinkowska-Gapińska A, Kowal P. Hemorheological studies of chosen clinical cases. J Med Sci. 2015;84(3):197–200.

Chmiel H. Determination of blood rheological parameters and clinical application. Advances in Cardiovascular Physics. 1979;3:1–44.

Lerche D, Bämler H, Kucera W, Meier W, Paulitschke M. Flow properties of blood and hemoreological methods of quantification. In: Scütt W, Klinkmann H, Lamprecht I, Wilson T (eds.). Physical Characterization of Biological cells. Basic research and clinic relevance. Verlag Gesundheit GmbH Berlin, 1991. p. 189–214.

Marossy A, Svorc P, Kron I, Gresova S, Hemorhology and circulation. Clin. Hemorheol and Microcirc. 2009;42:239–258.

Huang CR, Pan WD, Chen HQ, Copley AL. Thixotropic properties of whole blood form healthy human subjects. Biorheology. 1987;24(6):795–801.

Tropea C, Yarin AL, Foss JF. Springer Handbook of Experimental Fluid Mechanics. Springer-Verlag Berlin Heidelberg, 2007.

Kowal P. Quantitative study of fibrinogen molecules contribution to the inter-red cells conections in selected clinical groups of stroke patients. Clin Hemorheol Microcirc. 1998;1:37–41.

Kowal P, Walzl M, Lechner H. The influence of H.E.L.P. system on field shear stress In vascular disease. Clin Haemoreol. 1993;13(5):701–706.

Vermylen J, Blockmans D, Spitz B, Deckmyn H. Thrombosis and immune disorders. Clin Haematol. 1986;15:393–412.

Członkowska A, Meurer M, Palasik W, Barańska-Gieruszczak M, Mendel T, Wierzchowska E. Anticariolipin antiobodies, a disease marker for ischemic cerebrovascular events in a younger patients populations? Acta Neurol Scand. 1992;3:304–307.

Hess DC, Krauss J, Adams RJ. Nichols FT, Zhang D, Rountree HA. Anticardiolipin antibodies: a study of frequency in TIA and stroke. Neurology. 1991;4:525–528.

Levine S, Kim S, Deegan M, Welch KMA. Ichemic Stroke Associated with Anticariolipin Antibodies. Stroke. 1987;18:1101–1106.

Montalban J, Codina A, Ordi J, Vilardel M, Khamashata MA, Hughes GRV. Antiphospholipid antibodies in Cerebral Ischemia. Stroke. 1981;22:750–753.

Donner M, Mills P, Stoltz JE. Influence of plasma proteins on erythrocyte aggregation. Clin Hemorheol. 1989;9:715–721.

Maeda N, Sekiya M, Kameda K, Shiga T. Effect of immunoglobulin prepartations on the aggregation of human erytrocytes. Eur J Clin Invest. 1986;16:184–191.

Baskurt O, Meiselman H. Erythrocyte aggregation: basic aspects and clinical importance. Clin Hemorheol Microcirc. 2013;53:23–37.

Koenig W, Ernst E. The possible role of hemorheology in atherothrombogenesis. Atherosclerosis. 1992;94(2–3):93–107.

Janzen J, Brooks DE. Do plasma proteins adsorb to red cells? Clin Hemorheol. 1989;9:695–714.

Skalak R, Cheng Z. Rheological Aspects of red blood cell aggregation. Biorheology. 1990;27:309–325.

How to Cite

Kowal P, Marcinkowska-Gapinska A. Thixotropic effect of some biochemical factors in ischaemic stroke. JMS [Internet]. 2018 Mar. 30 [cited 2023 Jun. 4];87(1):7-10. Available from:



Original Papers
Received 2017-03-18
Published 2018-03-30