Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods

  • Jan Matysiak Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Paweł Dereziński Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Agnieszka Klupczyńska Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Joanna Hajduk Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Agata Światły Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Szymon Plewa Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
  • Agnieszka Horała Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, Poznań 60-535, Poland
  • Patryk Jaźwiński Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland
  • Paulina Banach Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, Poznań 60-535, Poland;
  • Ewa Nowak-Markwitz Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, Poznań 60-535, Poland;
  • Zenon J. Kokot Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland
Keywords: ovarian cancer, prostate cancer, proteomics, metabolomics

Abstract

The project entitled ”Proteomic and metabolomic strategy of searching for biomarkers of genital cancer diseases using mass spectrometry methods” is a study based on novel omics techniques. The main assumption of this research is the development of innovative model of searching of biomarkers in ovarian and prostate cancers using proteomics and metabolomics methodologies supported by bioinformatics analysis. The innovatory strategy based on the latest achievements in the field of mass spectrometry will allow for the implementation of the unique studies for discovery new biomarkers, which are useful in prediction, diagnosis and treatment of the genital cancers. To date, there is no comprehensive data including set of proteins and other endogenous compounds involved in the development and differentiation of these diseases. Therefore, the proposed approach may contribute to the discovery of biomarkers with high sensitivity and specificity, which will provide new information about genital cancers characterization.