Characteristics of Regulatory T cells

  • Magdalena Frydrychowicz Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Maciej Boruczkowski Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Agata Kolecka-Bednarczyk Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Renata Jenek Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Joanna Rosołowska Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Agnieszka Pluto-Prądzyńska Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
  • Grzegorz Dworacki Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Keywords: Tregs, regulatory T cells, autoimmunity, cancer

Abstract

Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-). CD25, CD45Ro, CD152, GITR, LAG-3, several adhesion molecules, chemokine receptors as well as Toll-like receptors are present on the surface of Treg. Mechanism of suppression used by nTreg is not completely understood.