Published: 2016-12-29

Perspectives for gallotannins neuroprotective potential - current experimental evidences

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Radosław Kujawski

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland
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Małgorzata Kujawska

Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland

Department of Pharmaceutical Botany and Biotechnology, Poznan University of Medical Sciences, Poznan, Poland
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Marcin Ożarowski

Department of Pharmaceutical Botany and Biotechnology, Poznan University of Medical Sciences, Poznan, Poland
Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Poznan, Poland
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Justyna Baraniak

Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Poznan, Poland

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Halina Laskowska

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Tamara Nowocień

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Magdalena Borowska

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Michał Szulc

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznan, Poland
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Agnieszka Sobczak

Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznan, Poland

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
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Przemysław Mikołajczak

Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
neuroprotection plant extract gallotannins galloylated cyanogenic glycosides poly(ADP-ribose) glycohydrolase 1 2 3 4 6-penta-O-galloyl-ß-D-glucopyranose

Abstract

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin-rich plant preparations might be effective at reversing neurodegenerative pathology and age-related declines in neurocognitive performance. This mini-review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP-ribose) glycohydrolase (PARP).

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References

  1. Rodriguez-Mateos A, Vauzour D, Krueger CG, Shanmuganayagam D, Reed J, Calani L, Mena P, Del Rio D, Crozier A. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol. 2014;88(10):1803–53.
  2. Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18(14):1818–92.
  3. Tejada S, Setzer W, Daglia M et al. Neuroprotective effects of Ellagitannins: A brief review. Curr Drug Targets. 2016 [Epub ahead of print].
  4. Gong YS, Guo J, Hu K, Gao YQ, Xie BJ, Sun ZD, Yang EN, Hou FL. Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by D-galactose. Exp Gerontol. 2016;74:21–8.
  5. Smeriglio A, Barreca D, Bellocco E, Trombetta D. Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects. Br J Pharmacol. 2016 Sep 20. doi: 10.1111/bph.13630. [Epub ahead of print].
  6. Ebrahimi A, Schluesener H. Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Ageing Res Rev. 2012;11:329–345.
  7. Tomás-Barberán FA, González-Sarrías A, García-Villalba R et al. Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status. Mol Nutr Food Res. 2016. doi: 10.1002/mnfr.201500901. [Epub ahead of print].
  8. Caruana M, Cauchi R, Vassallo N. Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease. Front Nutr. 2016;12:3–31.
  9. Spencer JP, Vafeiadou K, Williams RJ, et. al. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med. 2012;33:83–97.
  10. Williams RJ, Spencer JP. Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic. Biol. Med. 2012;52:35–45.
  11. Mandel SA, Amit T, Kalfon L, Reznichenko L, Weinreb O, Youdim MB. Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG). J Alzheimers Dis. 2008;15(2):211–22.
  12. Terasawa K, Shimada Y, Kita T, Yamamoto T, Tosa H, Tanaka N, Saito Y, Kanaki E, Goto S, Mizushima N, Fujioka M, Takase S, Seki H, Kimura I, Ogawa T,Nakamura S, Araki G, Maruyama I, Maruyama Y, Takaori S. Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study. Phytomedicine. 1997;4(1):15–22.
  13. Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypoperfusion-induced spatial learning deficit via stimulation of muscarinic M1 receptor. Pharmacol Biochem Behav. 2005;81(3):616–25.
  14. Kanno H, Kawakami Z, Tabuchi M, Mizoguchi K, Ikarashi Y, Kase Y. Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid ß oligomer-induced neuronal death. J Ethnopharmacol. 2015;159:122–8.
  15. Ikarashi Y, Mizoguchi K. Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. Pharmacol Ther. 2016;166:84–95.
  16. Itoh T, Shimada Y, Terasawa K. Efficacy of Choto-san on vascular dementia and the protective effect of the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. Mech Ageing Dev. 1999;111(2–3):155–73.
  17. Shimada Y, Goto H, Kogure T, Shibahara N, Sakakibara I, Sasaki H, Terasawa K. Protective effect of phenolic compounds isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. Am J Chin Med. 2001;29(1):173–80.
  18. Tsai YJ, Aoki T, Maruta H, Abe H, Sakagami H, Hatano T, Okuda T, Tanuma S. Mouse mammary tumor virus gene expression is suppressed by oligomeric ellagitannins, novel inhibitors of poly(ADPribose) glycohydrolase. J. Biol. Chem. 1992;267:14436–14442.
  19. Aoki K, Nishimura K, Abe H, Maruta H, Sakagami H, Hatano T, Okuda T, Yoshida T, Tsai YJ, Uchiumi F. Novel inhibitors of poly(ADP-ribose) glycohydrolase. Biochim Biophys Acta. 1993;1158:251–256.
  20. Ying W, Swanson RA. The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death. Neuroreport. 2000;11(7):1385–8.
  21. Ying W, Sevigny MB, Chen Y, Swanson RA. Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc Natl Acad Sci USA. 2001;98(21):12227–32.
  22. Falsig J, Christiansen SH, Feuerhahn S, Bürkle A, Oei SL, Keil C, Leist M. Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. Eur J Pharmacol. 2004;497(1):7–16.
  23. Chiesi M, Schwaller, R. Inhibition of constitutive endothelial NO synthase activity by tannin and quercetin. Biochem. Pharmacol. 1995;49:495–501.
  24. Kaneko M, Saito Y, Saito H, Matsumoto T, Matsuda Y, Vaught JL, Dionne CA, Angeles TS, Glicksman MA, Neff NT, Rotella DP, Kauer JC, Mallamo JP, Hudkins RL, Murakata C. Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J Med Chem. 1997;40:1863–1869.
  25. Ha, HC, Hester, LD, Snyder, SH. Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc Natl Acad Sci USA. 2002;99:3270–3275.
  26. Labieniec M, Gabryelak T, Falcioni G. Antioxidant and prooxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus. Mutat. Res. 2003;539:19–28.
  27. Lopes GK, Schulman HM, Hermes-Lima M. Polyphenol tannic acid inhibits hydroxyl radical formation from Fenton reaction by complexing ferrous ions. Biochim Biophys Acta. 1999;1472:142–152.
  28. Keil C, Petermann E, Oei, SL. Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts. Arch Biochem Biophys. 2004;425:115–121.
  29. Choi BM, Kim HJ, Oh GS, Pae HO, Oh H, Jeong S, Kwon TO, Kim YM, Chung HT. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose protects rat neuronal cells (Neuro 2A) from hydrogen peroxide-mediated cell death via the induction of heme oxygenase-1. Neurosci Lett. 2002;328(2):185–9.
  30. Tan HP, Wong DZ, Ling SK, Chuah CH, Kadir HA. Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia. Fitoterapia. 2012;83(1):223–9.
  31. Warden BA, Smith LS, Beecher GR, Balentine DA, Clevidence BA. Catechins are bioavailable in men and women drinking black tea throughout the day. J Nutr. 2001;131:1731–1737.
  32. Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. J Neurochem. 2009;109(6):1648–57.
  33. Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T. Tannic acid is a natural ß-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem. 2012;287(9):6912–27.
  34. Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, Finn MB, Holtzman DM. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer'sdisease. Neurobiol Dis. 2006;24(3):506–15.

How to Cite

1.
Kujawski R, Kujawska M, Ożarowski M, Baraniak J, Laskowska H, Nowocień T, Borowska M, Szulc M, Sobczak A, Mikołajczak P. Perspectives for gallotannins neuroprotective potential - current experimental evidences. JMS [Internet]. 2016Dec.29 [cited 2020Aug.8];85(4):317. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/172