Perspectives for gallotannins neuroprotective potential - current experimental evidences

  • Radosław Kujawski Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
  • Małgorzata Kujawska Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland
  • Marcin Ożarowski Department of Pharmaceutical Botany and Biotechnology, Poznan University of Medical Sciences, Poznan, Poland
  • Justyna Baraniak Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Poznan, Poland
  • Halina Laskowska Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
  • Tamara Nowocień Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
  • Magdalena Borowska Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
  • Michał Szulc Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
  • Agnieszka Sobczak Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznan, Poland
  • Przemysław Mikołajczak Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland
Keywords: neuroprotection, plant extract, gallotannins, galloylated cyanogenic glycosides, poly(ADP-ribose) glycohydrolase, 1, 2, 3, 4, 6-penta-O-galloyl-ß-D-glucopyranose

Abstract

Gallotannins are class of hydrolyzable tannins consisting of gallic acid and a sugar moiety. Currently, there is growing interest around a possible neuroprotective effect of this class of phytochemicals, which is suggested to be a result of their active metabolites. Evidence from experimental studies has suggested that tannin-rich plant preparations might be effective at reversing neurodegenerative pathology and age-related declines in neurocognitive performance. This mini-review summarizes, based on experimental studies, current knowledge about diverse neuroprotective abilities of gallotannins, mostly via antioxidant properties and some mechanisms of the effect are proposed including blocking accumulation of nitrites, inhibiting expression and activity of heme oxygenase 1(HO-1), and decreasing degradation of poly(ADP-ribose) glycohydrolase (PARP).