Comparison of Direct Lateral (Hardinge) and Direct Superior Approaches in Total Hip Arthroplasty – Effects on Perioperative Blood Loss and Transfusion Risk
DOI:
https://doi.org/10.20883/medical.e1547Keywords:
Total Hip Arthroplasty, Direct Superior Approach, Hardinge Approach, Perioperative Blood Loss, Blood TrasfusionAbstract
Background. Total hip arthroplasty (THA) can be performed through several approaches, including the direct superior (DSA) and direct lateral (Hardinge) approach. Perioperative blood loss and transfusion requirements remain key determinants of postoperative recovery and complications. This retrospective cohort study aimed to quantitatively compare perioperative blood loss and transfusion rates between DSA and Hardinge approaches in primary THA.
Material and methods. 215 consecutive adults who underwent primary unilateral THA (106 DSA, 109 Hardinge) were analysed. Perioperative blood loss (PBL) was estimated using Nadler’s formula for blood volume and Gross’s method based on perioperative haematocrit values from the preoperative day to postoperative day 2. Demographic variables and perioperative laboratory parameters were collected. Univariable and multivariable logistic regression assessed whether the Hardinge approach was associated with transfusion after adjustment for age, sex and body mass index (BMI).
Results. Mean PBL was lower with DSA than with Hardinge (1.153 L [SD 0.489] vs 1.323 L [SD 0.506]; P = .013). Overall, 17 patients (7.9%) required transfusion (3.8% DSA vs 11.9% Hardinge; P = .041). In multivariable analysis, the Hardinge approach remained associated with higher odds of transfusion (adjusted odds ratio, 3.63; 95% confidence interval, 1.19–13.7; P = .034), whereas age, sex and BMI were not statistically significant predictors. The model showed modest discrimination (AUC, 0.74) and acceptable calibration.
Conclusions. DSA was associated with lower PBL and a reduced likelihood of red blood cell transfusion in primary THA. These findings support the use of minimally invasive approaches such as DSA to minimise blood loss–related morbidity.
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References
Pivec R, Johnson AJ, Mears SC, Mont MA. Hip arthroplasty. The Lancet. Elsevier; 2012;380:1768–77. https://doi.org/10.1016/S0140-6736(12)60607-2 DOI: https://doi.org/10.1016/S0140-6736(12)60607-2
Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030. JBJS. 2007;89:780. https://doi.org/10.2106/JBJS.F.00222 DOI: https://doi.org/10.2106/JBJS.F.00222
Chalhoub R, MD, Aoun M, BS, Nham FH, MD, et al. Trends and Insights in Direct Anterior Total Hip Arthroplasty: A Comprehensive Bibliometric Analysis. Hip Pelvis. Korean Hip Society; 2025;37:53–63. https://doi.org/10.5371/hp.2025.37.1.53 DOI: https://doi.org/10.5371/hp.2025.37.1.53
Petis S, Howard JL, Lanting BL, Vasarhelyi EM. Surgical approach in primary total hip arthroplasty: anatomy, technique and clinical outcomes. Can J Surg. 2015;58:128–39. https://doi.org/10.1503/cjs.007214 DOI: https://doi.org/10.1503/cjs.007214
Chechik O, Khashan M, Lador R, Salai M, Amar E. Surgical approach and prosthesis fixation in hip arthroplasty world wide. Arch Orthop Trauma Surg. 2013;133:1595–600. https://doi.org/10.1007/s00402-013-1828-0 DOI: https://doi.org/10.1007/s00402-013-1828-0
Hardinge K. The direct lateral approach to the hip. J Bone Joint Surg Br. 1982;64:17–9. https://doi.org/10.1302/0301-620X.64B1.7068713 DOI: https://doi.org/10.1302/0301-620X.64B1.7068713
VAN DOOREN B, PETERS RM, ETTEMA HB, SCHREURS BW, VAN STEENBERGEN LN, BOLDER SBT, et al. Revision risk by using the direct superior approach (DSA) for total hip arthroplasty compared with postero-lateral approach: early nationwide results from the Dutch Arthroplasty Register (LROI). Acta Orthop. 2023;94:158–64. https://doi.org/10.2340/17453674.2023.11959 DOI: https://doi.org/10.2340/17453674.2023.11959
Markiewicz T, Bałonika A, Wójcik P, Buliński P, Chodór P, Kruczyński J. Early and late results of direct superior approach versus direct lateral approach in total hip arthroplasty – single-center, prospective study. Chir Narządów Ruchu Ortop Pol. Wydawnictwo Exemplum; 2023;88:99–102. https://doi.org/10.31139/chnriop.2023.88.3.1 DOI: https://doi.org/10.31139/chnriop.2023.88.3.1
Masonis JL, Bourne RB. Surgical approach, abductor function, and total hip arthroplasty dislocation. Clin Orthop. 2002;46–53. https://doi.org/10.1097/00003086-200212000-00006 DOI: https://doi.org/10.1097/00003086-200212000-00006
Pascarel X, Dumont D, Nehme B, Dudreuilh JP, Honton JL. [Total hip arthroplasty using the Hardinge approach. Clinical results in 63 cases]. Rev Chir Orthop Reparatrice Appar Mot. 1989;75:98–103.
Kwon MS, Kuskowski M, Mulhall KJ, Macaulay W, Brown TE, Saleh KJ. Does surgical approach affect total hip arthroplasty dislocation rates? Clin Orthop. 2006;447:34–8. https://doi.org/10.1097/01.blo.0000218746.84494.df DOI: https://doi.org/10.1097/01.blo.0000218746.84494.df
Wei Z, Xu Y, Zhu W, Weng X, Feng B. Direct superior approach versus posterolateral approach in mid-term clinical outcomes of total hip arthroplasty: a prospective randomized controlled study. BMC Musculoskelet Disord. 2025;26:92. https://doi.org/10.1186/s12891-024-08271-7 DOI: https://doi.org/10.1186/s12891-024-08271-7
Aggarwal VK, Iorio R, Zuckerman JD, Long WJ. Surgical Approaches for Primary Total Hip Arthroplasty from Charnley to Now: The Quest for the Best Approach. JBJS Rev. 2020;8:e0058. https://doi.org/10.2106/JBJS.RVW.19.00058 DOI: https://doi.org/10.2106/JBJS.RVW.19.00058
Miller LE, Gondusky JS, Bhattacharyya S, Kamath AF, Boettner F, Wright J. Does Surgical Approach Affect Outcomes in Total Hip Arthroplasty Through 90 Days of Follow-Up? A Systematic Review With Meta-Analysis. J Arthroplasty. 2018;33:1296–302. https://doi.org/10.1016/j.arth.2017.11.011 DOI: https://doi.org/10.1016/j.arth.2017.11.011
Ugbeye ME, Lawal WO, Ayodabo OJ, Adadevoh IP, Akpan IJ, Nwose U. An Evaluation of Intra- and Post-operative Blood Loss in Total Hip Arthroplasty at the National Orthopaedic Hospital, Lagos. Niger J Surg Off Publ Niger Surg Res Soc. 2017;23:42–6. https://doi.org/10.4103/1117-6806.205750 DOI: https://doi.org/10.4103/1117-6806.205750
Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58:277–80. https://doi.org/10.1097/00000542-198303000-00016 DOI: https://doi.org/10.1097/00000542-198303000-00016
Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51:224–32.
Ahn J, Lee HJ, Jeong BO. Assessment of perioperative total blood loss during total ankle arthroplasty. Foot Ankle Surg. 2022;28:564–9. https://doi.org/10.1016/j.fas.2021.05.011 DOI: https://doi.org/10.1016/j.fas.2021.05.011
Tian S, Li H, Liu M, Zhang Y, Peng A. Dynamic Analysis of Perioperative Hidden Blood Loss in Intertrochanteric Fractures. Clin Appl Thromb Off J Int Acad Clin Appl Thromb. 2019;25:1076029618823279. https://doi.org/10.1177/1076029618823279 DOI: https://doi.org/10.1177/1076029618823279
Yuan G, Xiao Y, Li Z, Chen Z, Liu X. Impact of surgical approaches on stem position and hidden blood loss in total hip arthroplasty: minimally invasive vs. posterolateral. BMC Musculoskelet Disord. 2024;25:681. https://doi.org/10.1186/s12891-024-07806-2 DOI: https://doi.org/10.1186/s12891-024-07806-2
Donovan RL, Lostis E, Jones I, Whitehouse MR. Estimation of blood volume and blood loss in primary total hip and knee replacement: An analysis of formulae for perioperative calculations and their ability to predict length of stay and blood transfusion requirements. J Orthop. 2021;24:227–32. https://doi.org/10.1016/j.jor.2021.03.004 DOI: https://doi.org/10.1016/j.jor.2021.03.004
Obada B, Georgeanu V, Iliescu M, Popescu A, Petcu L, Costea DO. Clinical outcomes of total hip arthroplasty after femoral neck fractures vs. osteoarthritis at one year follow up—A comparative, retrospective study. Int Orthop. 2024;48:2301–10. https://doi.org/10.1007/s00264-024-06242-0 DOI: https://doi.org/10.1007/s00264-024-06242-0
Pecold J, Pruc M, Nucera G, Kurek K, Szarpak L, Al-Jeabory M. Intra-articular versus intravenous tranexamic acid in total hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials. Adv Med Psychol Public Health. INAMPPH; 2024;1:185–98. https://doi.org/10.5281/zenodo.11075371
Yan L, Ge L, Dong S, Saluja K, Li D, Reddy KS, et al. Evaluation of Comparative Efficacy and Safety of Surgical Approaches for Total Hip Arthroplasty: A Systematic Review and Network Meta-analysis. JAMA Netw Open. 2023;6:e2253942. https://doi.org/10.1001/jamanetworkopen.2022.53942 DOI: https://doi.org/10.1001/jamanetworkopen.2022.53942
Ramadanov N, Voss M, Hable R, Prill R, Hakam HT, Salzmann M, et al. Patient-related Predictors for the Functional Outcome of SuperPATH Hemiarthroplasty versus Conventional Approach Hemiarthroplasty: A Systematic Review and Meta-regression Analysis of Randomized Controlled Trials. Orthop Surg. 2024;16:791–801. https://doi.org/10.1111/os.14006 DOI: https://doi.org/10.1111/os.14006
Shigemura T, Murata Y, Yamamoto Y, Shiratani Y, Hamano H, Wada Y. Minimally invasive anterolateral approach versus lateral transmuscular approach for total hip arthroplasty: A systematic review and meta-analysis. The Surgeon. 2022;20:e254–61. https://doi.org/10.1016/j.surge.2021.09.001 DOI: https://doi.org/10.1016/j.surge.2021.09.001
Shin K-H, Kim J-U, Jang I-T. Early Postoperative Outcomes of the Direct Superior Approach versus the Posterior Approach in Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. J Clin Med [Internet]. publisher; 2024 [cited 2026 Feb 28];13. https://doi.org/10.3390/jcm13216291 DOI: https://doi.org/10.3390/jcm13216291
Abdallah R, Asghar M, Jaber S, Chalfoun A, Ghosn A, Chaiban C, et al. Evaluating the direct superior approach compared to the traditional posterior approach for hip arthroplasty: A systematic review and meta-analysis. J Orthop. 2025;68:219–29. https://doi.org/10.1016/j.jor.2025.05.062 DOI: https://doi.org/10.1016/j.jor.2025.05.062
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