AbstractIn-stent restenosis (ISR) is a challenging complication of coronary stent implantation in both stable coronary artery disease (CAD) and acute coronary syndrome (ACS). Recent scientific aproach enables looking closely into its genetic background. This article briefly highlights the already known to increase susceptibility of ISR genetic polymorphisms and summarizes which were not proven to increase the risk of ISR and which may seem protective among CAD patients.
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- Kim MS, Dean LS, In-stent restenosis. Cardiovasc Ther. 2011 June;29(3):190–198.
- McCarroll SA, Kuruvilla FG, Korn JM, et al., Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet. 2008 Oct;40(10):1166–74.
- Osadnik T, Strzelczyk JK, Reguła R, et al. The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-ß1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent. Wallace GR, ed. PLoS ONE. 2016;11(3):e0150500. doi:10.1371/journal.pone.0150500.
- Osadnik T, Strzelczyk JK, et al. Relationship of the rs1799752 polymorphism of the angiotensin-converting enzyme gene and the rs699 polymorphism of the angiotensinogen gene to the process of in-stent restenosis in a population of Polish patients with stable coronary artery disease. Adv Med Sci. 2016 Mar 28;61(2):276–281. doi: 10.1016/j.advms.2016.03.006.
- Fragoso JM, Alvarez-León E, et al. The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting.Exp Mol Pathol. 2015 Aug;99(1):128–32. doi: 10.1016/j.yexmp.2015.06.012. Epub 2015 Jun 20.
- Fragoso JM, Zuniga-Ramos J. The T29C (rs1800470) polymorphism of the transforming growth factor-ß1 (TGF-ß1) gene is associated with restenosis after coronary stenting in Mexican patients.Exp Mol Pathol. 2015 Feb;98(1):13–7. doi: 10.1016/j.yexmp.2014.11.007. Epub 2014 Nov 13.
- Yang Y, Guo SX, et al. [Association between 1019C/T polymorphism of Connexin 37 gene and restenosis after coronary stenting].Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Aug;30(4):456–60.
- Liu W, Liu Y, et al. Plasma levels of interleukin 18, interleukin 10, and matrix metalloproteinase-9 and -137G/C polymorphism of interleukin 18 are associated with incidence of in-stent restenosis after percutaneous coronary intervention. Inflammation. 2013 Oct;36(5):1129–35
- Shuvalova YA, Kaminnyi AI, et al. Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis. Mol Cell Biochem. 2012 Nov;370(1–2):241–9.
- Gomma AH, Elrayess MA,et al. The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis. Eur Heart J. 2002 Dec;23(24):1955–62.
- Silvestre-Roig C, Fernández P, et al. Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis. Circ Cardiovasc Genet. 2014 Feb;7(1):59–70.
- Falcone C, Emanuele E, et al. The -374T/A variant of the rage gene promoter is associated with clinical restenosis after coronary stent placement. Int J Immunopathol Pharmacol. 2007 Oct-Dec;20(4):771–7.
- van Tiel CM1, Bonta PI,et al. p27kip1–838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity. Circulation. 2009 Aug 25;120(8):669–76.
- Nozari Y1, Vosooghi S, et al. The impact of cytochrome P450 2C19 polymorphism on the occurrence of one-year in-stent restenosis in patients who underwent percutaneous coronary intervention: A case-match study.Anatol J Cardiol. 2015 May;15(5):348–53. doi: 10.5152/akd.2014.5418.
- Beijk MA, Boekholdt SM, et al. Toll-like receptor 4 gene polymorphisms show no association with the risk of clinical or angiographic restenosis after percutaneous coronary intervention. Pharmacogenet Genomics. 2010 Sep;20(9):544–52
- Gao J, Cui RZ [Relationship of interleukin-10 gene polymorphism with restenosis after percutaneous coronary intervention in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Feb;28(1):42–6.