Published: 2016-09-28

Interleukin-7 receptor Thr244Ile gene polymorphism and the risk of systemic lupus erythematosus

Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań, Poland
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Pawel Piotr Jagodzinski

Head of the Department of Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań, Poland
Institute of Rheumatology, Warsaw, Poland
Interleukin-7 receptor SNP SLE

Abstract

Aim. Recently, the IL-7 receptor (IL-7R) C>T (rs6897932) single nucleotide polymorphism (SNP), which causes a Thr244Ile substitution in the IL-7R ?-chain, has been suggested as a risk factor for SLE.
Material and Methods. Using high-resolution melting curve analysis we studied the distribution of the IL-7R C>T polymorphism in SLE patients (n = 281) and control subjects (n = 541) in the Polish population.
Results. We did not find significant differences in the distribution of the IL-7R C>T genotype and alleles between SLE patients and controls. However, in the dominant model (T/T and C/T vs C/C genotypes), we observed a protective effect of the IL-7R C>T polymorphism against the presence of neurological manifestations of SLE [OR = 0.3631 (95% CI = 0.1895–0.6954), p = 0.0017, pcorr = 0.0323] and the presence of anti-Scl-70 antibodies (Ab) [OR = 0.3141 (95% CI = 0.1503–0.6561), p = 0.0014, pcorr = 0.0266].
Conclusion. Our studies suggest that the IL-7R C>T (rs6897932) polymorphism might be involved in the neurological manifestations and the presence of anti-Scl-70 Abs in patients with SLE.

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How to Cite

1.
Jagodzinski PP, Piotrowski P, Olesińska M. Interleukin-7 receptor Thr244Ile gene polymorphism and the risk of systemic lupus erythematosus. JMS [Internet]. 2016Sep.28 [cited 2020Aug.9];85(3):192-6. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/123