The effect of low advanced glycation end product diet on bone health and cardio-metabolic parameters in overweight and obese postmenopausal women: study protocol for a randomised controlled trial (AGEs study)

Małgorzata Jamka; Szymon Kurek; Anna Miśkiewicz-Chotnicka; Patrycja Krzyżanowska-Jankowska; Marek Walkowiak; Małgorzata Bęben; Natalia Wichłacz-Trojanowska; Jan Brylak; Aleksandra Makarewicz-Bukowska; Maria Chrobot; Natalia Jaworska; Joanna Popek; Jarosław Walkowiak

doi:10.20883/medical.e1194

Authors

Małgorzata Jamka Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-0257-6180
Szymon Kurek Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0002-1409-2933
Anna Miśkiewicz-Chotnicka Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-5073-2435
Patrycja Krzyżanowska-Jankowska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-8676-9803
Marek Walkowiak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-6554-8761
Małgorzata Bęben Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland
Natalia Wichłacz-Trojanowska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland
Jan Brylak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0003-1398-3387
Aleksandra Makarewicz-Bukowska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-9310-9643
Maria Chrobot Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0009-0004-0323-0378
Natalia Jaworska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0003-2871-1376
Joanna Popek Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0009-0008-1928-3764
Jarosław Walkowiak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznań, Poland https://orcid.org/0000-0001-5813-5707

DOI:

https://doi.org/10.20883/medical.e1194

Keywords:

postmenopause, overnutrition, metabolic diseases, bone density, nutrition therapy

Abstract

Advanced glycation end products (AGEs) have been suggested to play an important role in osteoporosis. However, no randomised controlled trial has investigated the effect of a diet with low AGEs on densitometric parameters. This study will evaluate the effect of a 12-month low AGEs diet on bone health and cardio-metabolic parameters in postmenopausal overweight and obese women. In total, 80 subjects will be included in the study and randomly divided into two groups: low AGEs diet and standard AGEs diet for 12 months. The mineral density and content will be measured at the lumbar spine, femoral neck, and total body during the pre- and post-intervention period. Selected markers of bone formation and resorption will be assessed. Anthropometric parameters and body composition will be evaluated and markers of glucose, insulin, lipid metabolism, inflammatory and endothelial parameters will be measured. Adherence to the diet will be monitored using dietary records.

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