The microbiome-mind connection: exploring gut health’s impact on depression
DOI:
https://doi.org/10.20883/medical.e1173Keywords:
gut-brain axis, gut microbiota, depression treatment, neurotransmitters' regulation, neuroinflammationAbstract
Introduction. The gut-brain axis is considered to be a crucial component of mental health, significantly influenced by the gut microbiota. This axis operates through neural (vagal nerve), hormonal (Hypothalamic-Pituitary-Adrenal axis), and immune pathways. Key mechanisms include microbial production of neurotransmitters like serotonin and gamma-aminobutyric acid, modulation of inflammatory responses and metabolic pathways involving short-chain fatty acids. Dysbiosis - a microbial imbalance - is associated with increased inflammation and neurotransmitter disruptions, both contributing to depressive symptoms.
Material and methods. The search strategy was centered on gathering high-quality articles focusing on the gut-brain axis and its implications for mental health, particularly depression. Databases including PubMed, Scopus, and Google Scholar were searched using keywords such as "gut-brain axis," "microbiota and mental health," "depression and gut microbiome," "gut neurotransmitters," "probiotics," and "inflammation and mood disorders." Studies were selected with a focus on research published mainly within the last two years.
Results. Potential interventions, such as administration of probiotics, prebiotics, dietary modifications, and innovative therapies like fecal microbiota transplantation and vagus nerve stimulation intend to restore the gut microbiota equilibrium.
Conclusions. Despite the limitations of current research, such as reliance on animal models, small human sample sizes, and methodological inconsistencies, expanding these studies remains highly valuable. Conducting large-scale human trials with standardized protocols and deeper exploring the interactions of specific microbial species could create a foundation for new approaches to supporting the treatment of depression effectively.
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References
Heravi FS, Rahman S. Gut Microbiota Composition in Patients with Neurodegenerative Disorders (Parkinson’s and Alzheimer’s) and Healthy Controls: A Systematic Review. Nutr. 2023;15(20):4365. doi: 10.3390/nu15204365.
Wernroth ML, West CE, Alderete TL, Velez MP, Pribyl MI, Tamain AM, Kumar K, Smith PE. Development of gut microbiota during the first 2 years of life. Sci Rep. 2022;12:13009. doi: 10.1038/s41598-022-13009-3.
Miller C, Smith J, Brown A, Johnson M, Williams P, Garcia R, Lee K, Walker S, Perez A, Davis B. Temporal Investigation of the Maternal Origins of Fetal Gut Microbiota. Microorganisms. 2024;12(9):1865. doi: 10.3390/microorganisms12091865.
Odiase E, Smith L, Johnson K, Brown P, Williams A, Garcia M, Martinez R, Lee T, Walker N, Perez J. The Gut Microbiota Differ in Exclusively Breastfed and Formula-Fed United States Infants and are Associated with Growth Status. J Pediatr. 2023;2023:114488. doi: 10.1016/j.jpeds.2023.114488.
Huang H, Liu Y, Wang J, Chen D, Zhang M, Li X, Zhao W, Chen S, Wu Z, Zhou Y, Zhang B. Exposure to prescribed medication in early life and impacts on gut microbiota and disease development. EClinicalMedicine. 2024;100007. doi: 10.1016/j.eclinm.2024.100007
Senghor B, Sokhatskyi V, Aly S, Vázquez-Carrera M, Kimura H, Durot M, Mackie A, Morita T, Nohara K, Yamamoto T, Sudo N. Gut microbiota diversity according to dietary habits and geographical provenance. Heliyon. 2018;3:e00359. doi: 10.1016/j.heliyon.2017.e00359.
Vinelli V, Bianchi F, Rossi L, Mele C, Vitali G, Pellegrini M, Bruno A, Ferrara G, Leone F, Romano P, Greco S. Effects of Dietary Fibers on Short-Chain Fatty Acids and Gut Microbiota Composition in Healthy Adults: A Systematic Review. Nutr. 2022;14(13):2559. doi: 10.3390/nu14132559.
Portincasa P, Vacca M, Leandro G, Santoro N, Bonfrate L, Wang DQH, Polimeno L. Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int J Mol Sci. 2022;23(3):1105. doi: 10.3390/ijms23031105.
Vila VA, Santos L, García R, Lopez M, Alvarez P, Sousa N, Rodrigues T, Fernandez J, Marques F, Ribeiro E, Oliveira H. Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases. Gut. 2024;73(11):1909. doi: 10.1136/gutjnl-2024-329456.
Armitage AOS, Thompson J, Smith H, Johnson D, White M, Brown L, Martin E, Collins K, Lee A, Walker R, Perez F, Davis S. Tripartite interactions: how immunity, microbiota and pathogens interact and affect pathogen virulence evolution. Curr Opin Infect Dis. 2022;45(3):1401. doi: 10.1016/j.cois.2021.12.001.
Ma J, Chen X, Liu Y, Wang H, Li Z, Zhang Q, Sun Y, Yang T, Zhao J, Hu L. The interaction among gut microbes, the intestinal barrier and short chain fatty acids. Food Biosci. 2022;12(3):1967. doi: 10.1016/j.fob.2021.12.003.
Karimi R, Hosseinzadeh D. Probiotics and Gastro-Intestinal Disorders. Augmentation, Enhancement, and Strengthening of Epithelial Lining. Probiotics. 2024;15(3):2249-9. doi: 10.1201/9781003452249-9.
Tsai HJ, Wang S, Lee H, Chang J, Chiu C, Chen Y, Lin P, Huang L, Kuo M, Liu H. Circulating Short-Chain Fatty Acids and Non-Alcoholic Fatty Liver Disease Severity in Patients with Type 2 Diabetes Mellitus. Nutr. 2023;15(7):1712. doi: 10.3390/nu15071712.
Guo X, Li R, Hou C. Breakfast skipping, microbiome composition, and major depressive disorder: a mendelian randomization study. Nutr J. 2024;24:01038-9. doi: 10.1186/s12937-024- 01038-9.
Lal S, Gupta A, Patel R, Singh J, Kumar V, Das P, Sharma N, Srivastava S, Mehta A, Reddy L. Chapter Seven - Gut microbiome dysbiosis in inflammatory bowel disease. Curr Opin Microbiol. 2022;22(1):007. doi: 10.1016/bs.mim.2022.01.007.
Vijayan S, Patel R, Kumar A, Gupta S, Sharma P, Das M, Mehta N, Singh R, Khanna T, Bhatia V, Rao G. Probiotics in Allergy and Immunological Diseases: A Comprehensive Review. Biomedicines. 2024;11(12):3128. doi: 10.3390/biomedicines11123128.
Steckler R, Magzal F, Kokot M, Walkowiak J, Tamir S. Disrupted gut harmony in attention-deficit/hyperactivity disorder: Dysbiosis and decreased short-chain fatty acids. Brain Behav Immun Health. 2024;10:100829. doi: 10.1016/j.bbih.2024.100829.
Cryan JF, Dinan TG, Clarke G, O'Riordan KJ, Sandhu K, Schellekens H, Begley DJ. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(2):187-225. doi: 10.1152/physrev.00018.2018.
Verma A, Sharma R, Gupta S, Patel N, Singh J, Kumar V, Das P, Srivastava A, Mehta S, Reddy M, Bhatia R. Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders. Cells. 2024;13(17):1436. doi: 10.3390/cells13171436.
Wei L, et al. Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction. Front Pharmacol. 2022;13:927446. doi: 10.3389/fphar.2022.927446.
Gershon MD, Margolis KG. The gut, its microbiome, and the brain: connections and communications. J Clin Invest. 2021;143:768. doi: 10.1172/JCI143768.
Császár-Nagy N, Kovács Z, Varga M, Simon L, Tóth K, Horváth R, Szabó G, Takács K, Fekete I, Nagy L. A Multidisciplinary Hypothesis about Serotonergic Psychedelics. Is it Possible that a Portion of Brain Serotonin Comes From the Gut? J Integr Neurosci. 2022;21(5):5148. doi: 10.31083/j.jin2105148.
Leon MT Dicks. Gut Bacteria and Neurotransmitters. Microorganisms. 2022;10(9):1838. doi: 10.3390/microorganisms10091838.
Liwinski T, Schramm G, Heinzel S, Pollmacher T, Szulc A, Müller N, Peters H, Schäfer M, Ziegler C, Maier W, Heuser I. Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut–Brain Axis. Biomedicines. 2023;11(12):3128. doi: 10.3390/biomedicines11123128.
Hinton T, Johnston AR, Graham J. GABA, epigallocatechin gallate, tea, and the gut- brain axis. J Nutr Biochem. 2024;110795. doi: 10.1016/j.jnutbio.2024.110795.
Casertano M, Rao A, Desai R, Smith P, Thompson E, Johnson M, Brown L, Garcia S, Lee J, Walker P, Perez N, Davis M. Gaba-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: A human Double-Blind Placebo- Controlled Cross-Over study. J Affect Disord. 2024;110897. doi: 10.1016/j.jad.2024.110897.
Strandwitz P, Kim KH, Terekhova D, Liu J, Sharma A, Levering J, Miller IJ, Jordan PM, Loach DM, Pauli G, Smith LP, Clardy J, Lewis K. GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2018;3:415-30. doi: 10.1038/s41564-018-0307-3.
Dalile B, Van Oudenhove L, Vervliet B, Bergonzelli GE, Verbeke K. Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial. EBioMedicine. 2020;59:102882. doi: 10.1016/j.ebiom.2020.102882.
Facchin, S.; Bertin, L.; Bonazzi, E.; Lorenzon, G.; De Barba, C.; Barberio, B.; Zingone, F.; Maniero, D.; Scarpa, M.; Ruffolo, C.; Angriman, I.; Savarino, E.V. Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications. Life 2024, 14(5), 559. doi: 10.3390/life14050559.
Kawahata, I.; Finkelstein, D.I.; Fukunaga, K. Dopamine D1–D5 Receptors in Brain Nuclei: Implications for Health and Disease. Receptors 2024, 3(2), 155-181. doi: 10.3390/receptors3020009.
Metz CN, Pavlov VA. Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome. Am J Physiol Gastrointest Liver Physiol. 2018;315(5):G651-G663. doi: 10.1152/ajpgi.00195.2018.
Pires R, Martins P, Silva R, Figueira L, Ribeiro J, Cardoso M, Matos A, Pinto J, Costa F, Sousa L, Gonçalves T. Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health. Appl Sci. 2024;14(20):9383. doi: 10.3390/app14209383.
Hamamah AA, He X, Lin H, Zhao Y, Chen Q, Li M, Chen S, Zhao W, Wang X, Zhang Y, Huang J. Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling. Transl Psychiatry. 2022;12(1):1-12. doi: 10.1038/s41398-022-01817-8.
Oryan Agranyoni S, Fishman Y, Poltyrev T, Kreisel T, Ben-Nun A, Yadid G, Gispan I, Shabat-Simon M, Shulman I, Benichou J, Shemesh Y. Colon impairments and inflammation driven by an altered gut microbiota lead to social behavior deficits rescued by hyaluronic acid and celecoxib. BMC Med. 2024;22:172. doi: 10.1186/s12916-024-03323-0.
Tette FM, Smith R, Johnson L, Brown K, Garcia M, Lee P, Walker S, Perez A, Davis B, Taylor J, Wilson D, Martinez R. Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity. Curr Issues Mol Biol. 2022;44(4):96. doi: 10.3390/cimb4404096.
Wasiak J, Gawlik-Kotelnicka O. Intestinal permeability and its significance in psychiatric disorders: A narrative review and future perspectives. Brain Behav Immun. 2023;103:004. doi: 10.1016/j.bbi.2023.103004.
Bonnechère B, Amin N, van Duijn C. The Role of Gut Microbiota in Neuropsychiatric Diseases: Creation of An Atlas-Based on Quantified Evidence. Front Cell Infect Microbiol. 2022;12:831666. doi: 10.3389/fcimb.2022.831666.
Mou Y, Du Y, Zhou L, Yue J, Hu X, Liu Y, Chen S, Lin X, Zhang G, Xiao H, Dong B. Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging. Front Immunol. 2022;13:796288. doi: 10.3389/fimmu.2022.796288.
Junyi L, Yueyang W, Bin L, Xiaohong D, Wenhui C, Ning Z, Hong Z. Gut Microbiota Mediates Neuroinflammation in Alzheimer’s Disease: Unraveling Key Factors and Mechanistic Insights. Mol Neurobiol. 2024;61:4513. doi: 10.1007/s12035-024-04513-w.
Hirasawa T, Satoh Y, Koma D. Production of aromatic amino acids and their derivatives by Escherichia coli and Corynebacterium glutamicum. World J Microbiol Biotechnol. 2025;41:65. doi: 10.1007/s11274-025-04264-3
Li S, Li Y, Cai Y, Yan Z, Wei J, Zhang H, Yue F, Chen T. Lacticaseibacillus paracasei NCU-04 relieves constipation and depressive-like behaviors in mice through the microbiome- gut-brain axis. J Psychosom Res. 2024;120:201. doi: 10.1016/j.jpsychores.2024.120201.
Tian P, Chen Y, Zhu H, Wang L, Qian X, Zou R, Zhao J, Zhang H, Qian L, Wang Q, Wang G, Chen W. Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial. J Affect Disord. 2022;295:6267. doi: 10.1016/j.jad.2021.123897.
Nel NH, Marafie A, Bassis CM, Sugino KY, Nzerem A, Knickmeyer RR, McKee KS, Comstock SS. Edinburgh postpartum depression scores associated with gut microbiota in pregnancy. J Affect Disord. 2024;302:587. doi: 10.1016/j.jad.2024.120587.
Delgado-Ocaña S, Cuesta S. From microbes to mind: germ-free models in neuropsychiatric research. MBio. 2024;15(4):e02075-24. doi: 10.1128/mBio.02075-24.
Wu M, Tian T, Mao Q, Zou T, Zhou CJ, Xie J, Chen JJ. Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice. Transl Psychiatry. 2020;10(1):38. doi: 10.1038/s41398-020-01038-3.
Ashique S, Mohanto S, Ahmed MG, Mishra N, Garg A, Chellappan DK, Omara T, Iqbal S, Kahwa I. Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application. Heliyon. 2024;10:e09842. doi: 10.1016/j.heliyon.2024.e09842.
Pletikosić Tončić S, Hauser G, Tkalčić M. Gut microbiota, mood, and disorders of the gut-brain axis. Front Microbiol. 2024;15:1098008. doi: 10.3389/fmicb.2024.1098008.
Ansari F, Neshat M, Pourjafar H, Jafari SM, Samakkhah SA, Mirzakhani E. The role of probiotics and prebiotics in modulating of the gut-brain axis. Cells. 2023;12(7):1045. doi: 10.3390/cells12071045.
Rahimian R, Belliveau C, Chen R, Mechawar N. Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder. Front Psychiatry. 2022;13:871997. doi: 10.3389/fpsyt.2022.871997.
Merino del Portillo M, Clemente-Suárez VJ, Ruisoto P, Jimenez M, Ramos-Campo DJ, Beltran-Velasco AI, Martínez-Guardado I, Rubio-Zarapuz A, Navarro-Jiménez E, Tornero- Aguilera JF. Nutritional Modulation of the Gut–Brain Axis in Depression. Nutr. 2024;16(10):2055. doi: 10.3390/nu16102055.
Xu Q, Sun L, Chen Q, Jiao C, Wang Y, Li H, Xie J, Zhu F, Wang J, Zhang W, Xie L, Wu H, Zuo Z, Chen X. Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model. J Affect Disord. 2024;311:347. doi: 10.1016/j.jad.2024.120347.
Zeng Z, Tang W. Gut microbiota: A potential player in psychiatric symptoms during COVID-19. Int J Soc Psychiatry. 2024;70:846. doi: 10.1080/15622975.2024.2342846.
Kaushal A. Microbiome to dictate the occurrence of neurological disorders. Microb Biotechnol. 2024;6:2348. doi: 10.1002/mbo3.2348.
Ma T, Jin H, Kwok LY, Sun Z, Liong MT, Zhang H. Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota. Heliyon. 2021;7:e09485. doi: 10.1016/j.heliyon.2021.e09485.
Noonan S, Zaveri M, Macaninch E, Martyn K. Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adults. Front Psychiatry. 2020;11:1297. doi: 10.3389/fpsyt.2020.01297.
Kazemi A, Noorbalab AA, Azam K, Eskandari MH, Djafarian K. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clin Nutr. 2019;38(3):123-130. doi: 10.1016/j.clnu.2018.03.013.
Stolfi F, Abreu H, Sinella R, Nembrini S, Centonze S, Landra V, Brasso C, Cappellano G, Rocca P, Chiocchetti A. Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine. Front Psychiatry. 2024;15:1422939. doi: 10.3389/fpsyt.2024.1422939.
Ribichini E, Scalese G, Mocci C, Severi C. Gut–Brain Axis and Psychopathology: Exploring the Impact of Diet with a Focus on the Low-FODMAP Approach. Nutr. 2024;16(20):3515. doi: 10.3390/nu16020555.
Zheng Y, Bonfili L, Wei T, Eleuteri AM. Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders. Nutr. 2023;15(21):4631. doi: 10.3390/nu15214631.
Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, Castle D, Dash S, Mihalopoulos C, Chatterton ML, Brazionis L, Dean OM, Hodge AM, Berk M. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Med. 2017;15(1):23. doi: 10.1186/s12916-017-0791-y.
Parletta N, Zarnowiecki D, Cho J, Wilson A, Bogomolova S, Villani A, Itsiopoulos C, Niyonsenga T, Blunden S, Meyer B, Segal L, Baune BT, O’Dea K. A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED). Nutr Neurosci. 2017;20(6):368-377. doi: 10.1080/1028415X.2017.1411320.
Opie RS, O’Neil A, Itsiopoulos C, Jacka FN. The impact of whole-of-diet interventions on depression and anxiety: a systematic review of randomised controlled trials. Public Health Nutr. 2015;18(11):2076-2091. doi: 10.1017/S1368980014002158.
Białoń N, Górka D, Górka M. The brain-gut axis: communication mechanisms and the role of the microbiome as a neuroprotective factor in the development of neurodegenerative diseases: A literature overview. AIMS Neurosci. 2024;11(1):19. doi: 10.3934/Neuroscience.2024019.
Radkhah N, Rasouli A, Majnouni A, Eskandari E, Parastouei K. The effect of Mediterranean diet instructions on depression, anxiety, stress, and anthropometric indices: A randomized, double-blind, controlled clinical trial. Prev Med Rep. 2023;36:102469. doi: 10.1016/j.pmedr.2023.102469.
Aljeradat B, Kumar D, Abdulmuizz S, Kundu M, Almealawy YF, Batarseh DR, Atallah O, Ennabe M, Alsarafandi M, Alan A, Weinand M. Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders. Biomedicines. 2024;11(2):2319. doi: 10.3390/biomedicines11212319.
Ma SN, Liu XH, Cai WS. Preventive noninvasive vagal nerve stimulation reduces insufficient sleep-induced depression by improving the autonomic nervous system. Sleep. 2024;78(3):105432. doi: 10.1016/j.sleep.2024.105432.
Guerriero G, Wartenberg C, Bernhardsson S, Gunnarsson S, Ioannou M, Liljedahl SI, Magnusson K, Svanberg T, Steingrimsson S. Efficacy of transcutaneous vagus nerve stimulation as treatment for depression: A systematic review. Brain Stimul. 2021;14(1):101-120. doi: 10.1016/j.brs.2021.01.001.
Shi X, Zhao L, Luo H, Deng H, Wang X, Ren G, Zhang L, Tao Q, Liang S, Liu N, Huang X, Zhang X, Yang X, Sun J, Qin W, Kang X, Han Y, Pan Y, Fan D. Transcutaneous Auricular Vagal Nerve Stimulation Is Effective for the Treatment of Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Am J Gastroenterol. 2024;119(3):325-335. doi: 10.1053/j.gastro.2024.01.025.
Zhang Q, et al. Current Landscape of Fecal Microbiota Transplantation in Treating Depression. Food Chem Toxicol. 2024;175:105223. doi: 10.1016/j.fct.2024.105223.
Kurokawa S, Kishimoto T, Mizuno S, Masaoka T, Naganuma M, Liang KC, Kitazawa M, Nakashima M, Shindo C, Suda W, Hattori M, Kanai T, Mimura M. The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. J Affect Disord. 2018;235:193. doi: 10.1016/j.jad.2018.02.193.
Li P, Zhao J, Wei X, Luo L, Chu Y, Zhang T, Zhu A, Yan J. Acupuncture may play a key role in anti-depression through various mechanisms in depression. Chin Med. 2024;12(1):990. doi: 10.1186/s13020-024-00990-2.
Yan X-Y, Yao J-P, Li Y-Q, Xiao X-J, Yang W-Q, Chen S-J, Tang T-C, Yang Y-Q, Qu L, Hou Y-J, Chen M, Li Y. Effects of acupuncture on gut microbiota and short-chain fatty acids in patients with functional constipation: a randomized placebo-controlled trial. Front Pharmacol. 2023;14:1223742. doi: 10.3389/fphar.2023.1223742.
Wang Y, Luo Z, Chen N, Han B, Li L, Liu L, Chen G, Yang C. Clinical research progress of traditional Chinese medicine in the treatment of GERD with anxiety and depression by regulating brain-gut axis. Chin J Pharm. 2024;15(3):18-22. doi: 10.6039/j.issn.1001-0408.2024.18.22.
Shi J, Zhang X, Chen J, Shen R, Cui H, Wu H. Acupuncture and moxibustion therapy for cognitive impairment: the microbiome–gut–brain axis and its role. Front Neurosci. 2024;17:1275860. doi: 10.3389/fnins.2023.1275860
Chetty A, Blekhman R. Multi-omic approaches for host-microbiome data integration. Gut Microbes. 2024;16(1):2297860. doi: 10.1080/19490976.2023.2297860.
Filardo S, Di Pietro M, Sessa R. Current progresses and challenges for microbiome research in human health: a perspective. Front Cell Infect Microbiol. 2024;14:1377012. doi: 10.3389/fcimb.2024.1377012.
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