Factors determining the prognosis of people with type 1 diabetes – current perspective

Authors

  • Aleksandra Araszkiewicz Department of Internal Medicine and Diabetology, Poznan Univeristy of Medical Sciences, Poland https://orcid.org/0000-0002-4955-6099
  • Kacper Trzaska Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Anna Soukharev Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Jakub Spławski Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Jan Wolbach Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Piotr Marek Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Kinga Dubel Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Weronika Wojak Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland
  • Dorota Zozulińska-Ziółkiewicz Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0003-2995-9971

DOI:

https://doi.org/10.20883/medical.e1122

Keywords:

Type 1 diabetes, life expectancy, mortality, complication risks, risk factors

Abstract

A multitude of factors strongly influences the prognosis of subjects with type 1 diabetes. In the literature, it's notable that only a limited number of studies simultaneously address multiple factors. Our objective is to identify and compile current papers that thoroughly examine these factors, offering a comprehensive overview of the various elements that can influence both life expectancy and the prevalence of complications among individuals with type 1 diabetes. In the overview, we included modifiable and non-modifiable factors. The paper covers technology development, comorbidities as well as acute and chronic complications as predictors. Greater focus on the significance of sex and age as a risk of macrovascular diabetes-related complications, age at onset of diabetes, and episodes of acute complications, can lead to more targeted management of type 1 diabetes and therefore, higher life expectancy. The article also discusses such environmental factors as lifestyle, education, and access to the healthcare system affecting better handling of type 1 diabetes. This overview emphasizes the plurality of factors that are considered in type 1 diabetes, which might be crucial to prolonging life expectancy and reducing the prevalence of complications.

Downloads

Download data is not yet available.

Author Biography

  • Aleksandra Araszkiewicz, Department of Internal Medicine and Diabetology, Poznan Univeristy of Medical Sciences, Poland

    Professor at the Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences. Member of the European Association for the Study of Diabetes. Diabetes Poland – a member of the Board 2019-2023, Chair of the Great Poland Region of the Diabetes Poland and member of EASD Neuropathy Working Group (NEURODIAB). Co-author of the Standards of Care in Diabetes. The position of Diabetes Poland. Author and co-author of 138 papers with total IF 203.

References

Mobasseri M, Shirmohammadi M, Amiri T, Vahed N, Hosseini Fard H, Ghojazadeh M. Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis. Health Promot Perspect 2020;10:98–115. https://doi.org/10.34172/hpp.2020.18.

Ruiz PLD, Chen L, Morton JI, Salim A, Carstensen B, Gregg EW, et al. Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts. Diabetologia 2022;65:964–72. https://doi.org/10.1007/s00125-022-05659-9.

Arffman M, Hakkarainen P, Keskimäki I, Oksanen T, Sund R. Long-term and recent trends in survival and life expectancy for people with type 1 diabetes in Finland. Diabetes Res Clin Pract 2023;198. https://doi.org/10.1016/j.diabres.2023.110580.

Tran-Duy A, Knight J, Clarke PM, Svensson A-M, Eliasson B, Palmer AJ. Development of a life expectancy table for individuals with type 1 diabetes. Diabetologia 2021;64:2228–36. https://doi.org/10.1007/s00125-021-05503-6.

Maresova P, Cerna L. Patients’ attitudes to the use of modern technologies in the treatment of diabetes. Patient Prefer Adherence 2016; Volume 10:1869–79. https://doi.org/10.2147/PPA.S118040.

Agrawal S, Makuch S, Dróżdż M, Dudzik T, Domański I, Poręba R, et al. The Impact of Hypoglycemia on Patients with Diabetes Mellitus: A Cross-Sectional Analysis. J Clin Med 2022;11:626. https://doi.org/10.3390/jcm11030626.

Klonoff DC, Parkes JL, Kovatchev BP, Kerr D, Bevier WC, Brazg RL, et al. Investigation of the Accuracy of 18 Marketed Blood Glucose Monitors. Diabetes Care 2018;41:1681–8. https://doi.org/10.2337/dc17-1960.

Salacinski AJ, Alford M, Drevets K, Hart S, Hunt BE. Validity and Reliability of a Glucometer Against Industry Reference Standards. J Diabetes Sci Technol 2014;8:95–9. https://doi.org/10.1177/1932296813514315.

Alshannaq H, Cogswell G, Pollock RF, Ahmed W, Norman GJ, Lynch PM, et al. Cost-utility of real-time continuous glucose monitoring versus self-monitoring of blood glucose and intermittently scanned continuous glucose monitoring in people with type 1 diabetes receiving multiple daily insulin injections in Denmark. Diabetes Obes Metab. 2023 Sep;25(9):2704-2713. doi: 10.1111/dom.15158.

Beck RW, Riddlesworth T, Ruedy K, Ahmann A, Bergenstal R, Haller S, et al. Effect of Continuous Glucose Monitoring on Glycemic Control in Adults With Type 1 Diabetes Using Insulin Injections: The DIAMOND Randomized Clinical Trial. JAMA 2017;317:371. https://doi.org/10.1001/jama.2016.19975.

Oser TK, Hall TL, Dickinson LM, Callen E, Carroll JK, Nease DE, et al. Continuous Glucose Monitoring in Primary Care: Understanding and Supporting Clinicians’ Use to Enhance Diabetes Care. Ann Fam Med 2022;20:541–7. https://doi.org/10.1370/afm.2876.

Pedersen‐Bjergaard U, Agesen RM, Brøsen JMB, Alibegovic AC, Andersen HU, Beck‐Nielsen H, et al. Comparison of treatment with insulin degludec and glargine U100 in patients with type 1 diabetes prone to nocturnal severe hypoglycaemia: The HypoDeg randomized, controlled, open‐label, crossover trial. Diabetes Obes Metab 2022;24:257–67. https://doi.org/10.1111/dom.14574.

Trevisan R, Conti M, Ciardullo S. Once-weekly insulins: a promising approach to reduce the treatment burden in people with diabetes. Diabetologia 2024. https://doi.org/10.1007/s00125-024-06158-9.

Staples AM, Poulsen M, Præstmark KAF, Sparre T, Sand Traberg M. The Needle Shield Size and Applied Force of Subcutaneous Autoinjectors Significantly Influence the Injection Depth. J Diabetes Sci Technol. 2024 Feb 22:19322968241231996. doi: 10.1177/19322968241231996.

Masierek M, Nabrdalik K, Janota O, Kwiendacz H, Macherski M, Gumprecht J. The Review of Insulin Pens—Past, Present, and Look to the Future. Front Endocrinol 2022;13:827484. https://doi.org/10.3389/fendo.2022.827484.

Friedman JG, Silberman P, Herrmann S, Aleppo G. Strategies to Increase the Use of Connected Insulin Pens Through Shared Decision-Making: A Quality Improvement Success Story. Clin Diabetes. 2024 Aug 15;42(4):474-478. doi: 10.2337/cd24-0056.

Friedman JG, Silberman P, Herrmann S, Aleppo G. Strategies to Increase the Use of Connected Insulin Pens Through Shared Decision-Making: A Quality Improvement Success Story. Clin Diabetes. 2024 Aug 15;42(4):474-478. doi: 10.2337/cd24-0056.

Lunati ME, Morpurgo PS, Rossi A, Gandolfi A, Cogliati I, Bolla AM, et al. Hybrid Close-Loop Systems Versus Predictive Low-Glucose Suspend and Sensor-Augmented Pump Therapy in Patients With Type 1 Diabetes: A Single-Center Cohort Study. Front Endocrinol 2022;13:816599. https://doi.org/10.3389/fendo.2022.816599.

Sherr JL, Buckingham BA, Forlenza GP, Galderisi A, Ekhlaspour L, Wadwa RP, Carria L, Hsu L, Berget C, Peyser TA, Lee JB, O'Connor J, Dumais B, Huyett LM, Layne JE, Ly TT. Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions. Diabetes Technol Ther. 2020 Mar;22(3):174-184. doi: 10.1089/dia.2019.0286.

Howsmon DP, Baysal N, Buckingham BA, Forlenza GP, Ly TT, Maahs DM, et al. Real-Time Detection of Infusion Site Failures in a Closed-Loop Artificial Pancreas. J Diabetes Sci Technol 2018;12:599–607. https://doi.org/10.1177/1932296818755173.

Heller S, White D, Lee E, Lawton J, Pollard D, Waugh N, et al. A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. Health Technol Assess 2017;21:1–278. https://doi.org/10.3310/hta21200.

OPTN/SRTR 2022 Annual Data Report n.d.

Boggi U, Baronti W, Amorese G, Pilotti S, Occhipinti M, Perrone V, et al. Treating Type 1 Diabetes by Pancreas Transplant Alone: A Cohort Study on Actual Long-term (10 Years) Efficacy and Safety. Transplantation 2022;106:147–57. https://doi.org/10.1097/TP.0000000000003627.

Ji M, Wang M, Hu W, Ibrahim M, Lentine KL, Merzkani M, et al. Survival After Simultaneous Pancreas‐Kidney Transplantation in Type 1 Diabetes: The Critical Role of Early Pancreas Allograft Function. Transpl Int 2022;35:10618. https://doi.org/10.3389/ti.2022.10618.

Hering BJ, Clarke WR, Bridges ND, Eggerman TL, Alejandro R, Bellin MD, et al. Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. Diabetes Care 2016;39:1230–40. https://doi.org/10.2337/dc15-1988.

Carlsson P-O, Espes D, Sedigh A, Rotem A, Zimerman B, Grinberg H, et al. Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus. Am J Transplant 2018;18:1735–44. https://doi.org/10.1111/ajt.14642.

Maxwell KG, Millman JR. Applications of iPSC-derived beta cells from patients with diabetes. Cell Rep Med 2021;2:100238. https://doi.org/10.1016/j.xcrm.2021.100238.

Weiskorn J, Danne T. Moving from insulin substitution to the treatment of the underlying autoimmune disease in type 1 diabetes. Horm Res Paediatr 2024. https://doi.org/10.1159/000539120.

Eliasson B, Lyngfelt L, Strömblad S-O, Franzén S, Eeg-Olofsson K. The significance of chronic kidney disease, heart failure and cardiovascular disease for mortality in type 1 diabetes: nationwide observational study. Sci Rep 2022;12:17950. https://doi.org/10.1038/s41598-022-22932-4.

Putula E, Kauppala T, Vanhamäki S, Haapakoski J, Laatikainen T, Metso S. All-cause mortality and factors associated with it in Finnish patients with type 1 diabetes. J Diabetes Complications. 2024 Dec;38(12):108881. doi: 10.1016/j.jdiacomp.2024.108881.

Tran-Duy A, Knight J, Palmer AJ, Petrie D, Lung TWC, Herman WH, et al. A Patient-Level Model to Estimate Lifetime Health Outcomes of Patients With Type 1 Diabetes. Diabetes Care 2020;43:1741–9. https://doi.org/10.2337/dc19-2249.

Bell S, Fletcher EH, Brady I, Looker HC, Levin D, Joss N, et al. End-stage renal disease and survival in people with diabetes: a national database linkage study. QJM Int J Med 2015;108:127–34. https://doi.org/10.1093/qjmed/hcu170.

Retinopathy, neuropathy, and foot care: Standards of Care in Diabetes—2025. Diabetes Care 2025;48(Suppl. 1):S252–S265

Araszkiewicz A, Bandurska-Stankiewicz E, Borys S, Broncel M, Budzyński A, Cyganek K, et al. Standards of Care in Diabetes. The position of Diabetes Poland – 2024. Curr Top Diabetes 2024;3:1–348. https://doi.org/10.5114/ctd/183052.

Rawshani Aidin, Rawshani Araz, Franzén Stefan, Eliasson Björn, Svensson Ann-Marie, Miftaraj Mervete, et al. Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes. N Engl J Med 2017;376:1407–18. https://doi.org/10.1056/NEJMoa1608664.

Klatsky AL, Zhang J, Udaltsova N, Li Y, Tran HN. Body Mass Index and Mortality in a Very Large Cohort: Is It Really Healthier to Be Overweight? Perm J 2017;21:16–142. https://doi.org/10.7812/TPP/16-142.

Qeadan F, Tingey B, Egbert J, Pezzolesi MG, Burge MR, Peterson KA, et al. The associations between COVID-19 diagnosis, type 1 diabetes, and the risk of diabetic ketoacidosis: A nationwide cohort from the US using the Cerner Real-World Data. PLoS ONE 2022;17:e0266809. https://doi.org/10.1371/journal.pone.0266809.

Barron E, Bakhai C, Kar P, Weaver A, Bradley D, Ismail H, et al. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol 2020;8:813–22. https://doi.org/10.1016/S2213-8587(20)30272-2.

Driscoll KA, Geno Rasmussen CR, O'Donnell H, Trojanowski P, Alman AC, Keshawarz A, Snell-Bergeon JK. Men with type 1 diabetes had a more than 7-fold odds of elevated depressive symptoms compared to men without diabetes. Diabetes Res Clin Pract. 2024 Dec 15;219:111947. doi: 10.1016/j.diabres.2024.111947.

Trief PM, Xing D, Foster NC, Maahs DM, Kittelsrud JM, Olson BA, et al. Depression in Adults in the T1D Exchange Clinic Registry. Diabetes Care 2014;37:1563–72. https://doi.org/10.2337/dc13-1867.

Ahola AJ, Harjutsalo V, Forsblom C, Pouwer F, Groop P-H, on behalf of the FinnDiane Study Group. Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes. Diabetes Care 2020;44:174–80. https://doi.org/10.2337/dc20-0493.

Rawshani A, Sattar N, Franzén S, Rawshani A, Hattersley AT, Svensson A-M, et al. Excess mortality and cardiovascular disease in type 1 diabetes in relation to age at onset: a nationwide study of 27,195 young adults with diabetes. Lancet Lond Engl 2018;392:477–86. https://doi.org/10.1016/S0140-6736(18)31506-X.

Harjutsalo V, Maric-Bilkan C, Forsblom C, Groop P-H. Impact of sex and age at onset of diabetes on mortality from ischemic heart disease in patients with type 1 diabetes. Diabetes Care 2014;37:144–8. https://doi.org/10.2337/dc13-0377.

Vurallı D, Jalilova L, Alikaşifoğlu A, Özön ZA, Gönç EN, Kandemir N. Cardiovascular Risk Factors in Adolescents with Type 1 Diabetes: Prevalence and Gender Differences. J Clin Res Pediatr Endocrinol. 2024 Mar 11;16(1):11-20. doi: 10.4274/jcrpe.galenos.2023.2023-12-12.

Pettus JH, Zhou FL, Shepherd L, Preblick R, Hunt PR, Paranjape S, et al. Incidences of Severe Hypoglycemia and Diabetic Ketoacidosis and Prevalence of Microvascular Complications Stratified by Age and Glycemic Control in U.S. Adult Patients With Type 1 Diabetes: A Real-World Study. Diabetes Care 2019;42:2220–7. https://doi.org/10.2337/dc19-0830.

Maahs DM, Hermann JM, Holman N, Foster NC, Kapellen TM, Allgrove J, et al. Rates of Diabetic Ketoacidosis: International Comparison With 49,859 Pediatric Patients With Type 1 Diabetes From England, Wales, the U.S., Austria, and Germany. Diabetes Care 2015;38:1876–82. https://doi.org/10.2337/dc15-0780.

Cengiz E, Xing D, Wong JC, Wolfsdorf JI, Haymond MW, Rewers A, et al. Severe Hypoglycemia and Diabetic Ketoacidosis among Youth with Type 1 Diabetes in the T1D Exchange Clinic Registry. Pediatr Diabetes 2013;14:447–54. https://doi.org/10.1111/pedi.12030.

Zimmermann AT, Lanzinger S, Kummernes SJ, Lund-Blix NA, Holl RW, Fröhlich-Reiterer E, et al. Treatment regimens and glycaemic outcomes in more than 100 000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from pediatric diabetes registries. Lancet Diabetes Endocrinol. 2025 Jan;13(1):47-56. doi: 10.1016/S2213-8587(24)00279-1.

Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur Heart J 2022;43:716–99. https://doi.org/10.1093/eurheartj/ehab892.

Huxley RR, Peters SAE, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2015;3:198–206. https://doi.org/10.1016/S2213-8587(14)70248-7.

Dabelea D, Kinney G, Snell-Bergeon JK, Hokanson JE, Eckel RH, Ehrlich J, et al. Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. Diabetes 2003;52:2833–9. https://doi.org/10.2337/diabetes.52.11.2833.

Costacou T, Miller RG, Bornfeldt KE, Heinecke JW, Orchard TJ, Vaisar T. Sex differences in the associations of HDL particle concentration and cholesterol efflux capacity with incident coronary artery disease in type 1 diabetes: The RETRO HDLc cohort study. J Clin Lipidol. 2024 Mar-Apr;18(2):e218-e229. doi: 10.1016/j.jacl.2024.01.004.

Curtin SC, Tejada-Vera B, Bastian BA. Deaths: Leading Causes for 2020. Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat Syst 2023;72:1–115.

Bebu I, Schade D, Braffett B, Kosiborod M, Lopes-Virella M, Soliman EZ, et al. Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care 2020;43:867–74. https://doi.org/10.2337/dc19-2292.

Xu S, Ilyas I, Little PJ, Li H, Kamato D, Zheng X, et al. Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies. Pharmacol Rev 2021;73:924–67. https://doi.org/10.1124/pharmrev.120.000096.

Besic H, Jeraj L, Spirkoska A, Jezovnik MK, Poredoš P. Deterioration of endothelial function of micro- and macrocirculation in patients with diabetes type 1 and 2. Int Angiol J Int Union Angiol 2017;36:354–61. https://doi.org/10.23736/S0392-9590.16.03798-6.

Heier M, Espeland CN, Brunborg C, Seljeflot I, Margeirsdottir HD, Hanssen KF, et al. Preserved endothelial function in young adults with type 1 diabetes. PLoS ONE 2018;13:e0206523. https://doi.org/10.1371/journal.pone.0206523.

Zhang X, Bullard KM, Gregg EW, Beckles GL, Williams DE, Barker LE, et al. Access to health care and control of ABCs of diabetes. Diabetes Care 2012;35:1566–71. https://doi.org/10.2337/dc12-0081.

Liese AD, Ma X, Reid L, Sutherland MW, Bell BA, Eberth JM, et al. Health care access and glycemic control in youth and young adults with type 1 and type 2 diabetes in South Carolina. Pediatr Diabetes 2019;20:321–9. https://doi.org/10.1111/pedi.12822.

Lafontaine S, Mok E, Frei J, Henderson M, Rahme E, Dasgupta K, et al. Associations of Diabetes-related and Health-related Quality of Life With Glycemic Levels in Adolescents With Type 1 Diabetes Preparing to Transition to Adult Care. Can J Diabetes. 2023 Aug;47(6):525-531. doi: 10.1016/j.jcjd.2023.05.002.

Hermanns N, Kulzer B, Ehrmann D, Bergis-Jurgan N, Haak T. The effect of a diabetes education programme (PRIMAS) for people with type 1 diabetes: Results of a randomized trial. Diabetes Res Clin Pract 2013;102:149–57. https://doi.org/10.1016/j.diabres.2013.10.009.

Gagliardino JJ, Chantelot J-M, Domenger C, Ramachandran A, Kaddaha G, Mbanya JC, et al. Impact of diabetes education and self-management on the quality of care for people with type 1 diabetes mellitus in the Middle East (the International Diabetes Mellitus Practices Study, IDMPS). Diabetes Res Clin Pract 2019;147:29–36. https://doi.org/10.1016/j.diabres.2018.09.008.

Verchota G, Sawin KJ. Testing Components of a Self-Management Theory in Adolescents With Type 1 Diabetes Mellitus. Nurs Res 2016;65:487–95. https://doi.org/10.1097/NNR.0000000000000180.

Alarcón-Gómez J, Calatayud J, Chulvi-Medrano I, Martín-Rivera F. Effects of a HIIT Protocol on Cardiovascular Risk Factors in a Type 1 Diabetes Mellitus Population. Int J Environ Res Public Health. 2021 Jan 31;18(3):1262. doi: 10.3390/ijerph18031262.

Alarcón-Gómez J, Chulvi-Medrano I, Martin-Rivera F, Calatayud J. Effect of High-Intensity Interval Training on Quality of Life, Sleep Quality, Exercise Motivation and Enjoyment in Sedentary People with Type 1 Diabetes Mellitus. Int J Environ Res Public Health 2021;18:12612. https://doi.org/10.3390/ijerph182312612.

Lee AS, Johnson NA, McGill MJ, Overland J, Luo C, Baker CJ, et al. Effect of High-Intensity Interval Training on Glycemic Control in Adults With Type 1 Diabetes and Overweight or Obesity: A Randomized Controlled Trial With Partial Crossover. Diabetes Care 2020;43:2281–8. https://doi.org/10.2337/dc20-0342.

Turton JL, Brinkworth GD, Parker HM, Lim D, Lee K, Rush A, et al. Effects of a low-carbohydrate diet in adults with type 1 diabetes management: A single arm non-randomised clinical trial. PloS One 2023;18:e0288440. https://doi.org/10.1371/journal.pone.0288440.

Muntis FR, Smith-Ryan AE, Crandell J, Evenson KR, Maahs DM, Seid M, et al. A High Protein Diet Is Associated with Improved Glycemic Control Following Exercise among Adolescents with Type 1 Diabetes. Nutrients 2023;15:1981. https://doi.org/10.3390/nu15081981.

Weiman DI, Mahmud FH, Clarke ABM, Assor E, McDonald C, Saibil F, et al. Impact of a Gluten-Free Diet on Quality of Life and Health Perception in Patients With Type 1 Diabetes and Asymptomatic Celiac Disease. J Clin Endocrinol Metab 2021;106:e1984–92. https://doi.org/10.1210/clinem/dgaa977.

Dłużniak-Gołaska K, Panczyk M, Szostak-Węgierek D, Szypowska A, Sińska B. Analysis of the diet quality and dietary habits of children and adolescents with type 1 diabetes. Diabetes Metab Syndr Obes Targets Ther 2019;12:161–70. https://doi.org/10.2147/DMSO.S186237.

Downloads

Published

2024-12-31

Issue

Section

Review Papers

How to Cite

1.
Araszkiewicz A, Trzaska K, Soukharev A, Spławski J, Wolbach J, Marek P, et al. Factors determining the prognosis of people with type 1 diabetes – current perspective. JMS [Internet]. 2024 Dec. 31 [cited 2025 Jan. 22];:e1122. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/1122