Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis
AbstractBackground: The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium-dependent vasodilation induced by albuterol. Little is known of the effect of shear-stress-induced vasorelaxation on RIDVP.Methods: Thirty three healthy volunteers (22 females, 11 males, mean age 57 yrs) were recruited. Assessment of endothelium-dependent vasorelaxation was performed by the analysis of digital volume pulse after albuterol challenge or locally-induced hyperemia.Results: The hyperemia-induced vasodilation led to a significant decrease of RIDVP in comparison with the values obtained at rest (DRIHyper 69 ± 2 % vs 64 ± 2 , p<0.0001). Similarly albuterol administration resulted in a significant drop in RIDVP (DRIAlb 71 ± 2 % vs 67 ± 2 %, p<0.0001). There was no significant difference between DRIHyper and DRIAlb (5.2 ± 0.8 % vs 4.6 ± 1.0 %, p=0.61). We observed a significant correlation between the small vessel reaction in response to albuterol or hyperemia (r=0.52, p=0.01).Conclusions: Our study demonstrated that hyperemia-induced changes in the Reflexion Index derived from the digital volume pulse are similar to those observed after albuterol-challenge and both are correlated.
Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840–844.
Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23:168–175.
Gimbrone MA Jr. Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol. 1995;75:67B–70B.
Anderson TJ, Gerhard MD, Meredith IT, Charbonneau F, Delagrange D, Creager MA, Selwyn AP, Ganz P. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol. 1995;75:71B–74B.
Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation. 2003;108:2054–2059.
Laurent S, Lacolley P, Brunel P, Laloux B, Pannier B, Safar M. Flow-dependent vasodilation of brachial artery in essential hypertension. Am J Physiol. 1990;258:H1004–11.
Concetta I, Ceravolo R, Notarangelo L, Crescenzo A, Ventura G, Tamburrini O, Perticone F, Gnasso A Comparison of endothelial function evaluated by strain gauge plethysmography and brachial artery ultrasound. Atherosclerosis. 2001:158;53–59.
Millasseau SC, Kelly RP, Ritter JM, CHowienczyk PJ. Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clinical Science. 2002:103;371–377.
Millasseau SC, Kelly RP, Ritter JM, Chowienczyk PJ. The vascular impact of aging and vasoactive drugs: comparison of two digital volume pulse measurements. Am J Hypert. 2003;16:467–472.
Chowienczyk PJ, Kelly RP, MacCallum H, Millasseau SC, Andersson TLG, Gosling RG, Ritter JM, Anggard EE. Photoplethysmographic assessment of pulse wave reflection: blunted endothelium-dependent response to beta2 adrenergic vasodilation in type II diabetes. J Am Coll Cardiol. 1999;34:2007–2014.
Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–265.
Vallance P, Norman Endothelial function and nitric oxide: clinical relevance. Heart. 2001;85:342–350.
Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003;108:2049 –2053.
Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003;42:1149–1160.
Ludmer PL, Selwyn AP, Shook TL, Wayne R. R., Mudge G. H., Alexander R. W., Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046–1051.
Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899–1906.
Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101:948–954.
Targonski PV, Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Lerman A. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation. 2003;107:2805–2809.
Kalra L, Rambaran C, Chowienczyk PJ, Goss D, Hambleton I, Ritter J, Shah A, Wilks R, Forrester T. Ethnic differences in arterial responses and inflammatory markers in afro-caribbean and caucasian subjects. Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2362–7.