Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis

Keywords: endothelial-dependent vasodilation, digital volume pulse, albuterol

Abstract

Background: The Reflection Index (RIDVP) derived from digital volume pulse (DVP) analysis has proved to be useful in the assessment of endothelium-dependent vasodilation induced by albuterol.  Little is known of the effect of shear-stress-induced vasorelaxation on RIDVP.Methods:  Thirty three healthy volunteers (22 females, 11 males, mean age 57 yrs) were recruited. Assessment of endothelium-dependent vasorelaxation was performed by the analysis of digital volume pulse after albuterol challenge or locally-induced hyperemia.Results: The hyperemia-induced vasodilation led to a significant decrease of        RIDVP in comparison with the values obtained at rest (DRIHyper 69 ± 2 % vs 64 ± 2 , p<0.0001). Similarly albuterol administration resulted in a significant drop in RIDVP (DRIAlb 71 ± 2 % vs 67 ± 2 %, p<0.0001). There was no significant difference between DRIHyper and DRIAlb (5.2 ± 0.8 % vs 4.6 ± 1.0 %, p=0.61). We observed a significant correlation between the small vessel reaction in response to albuterol or hyperemia (r=0.52, p=0.01).Conclusions:  Our study demonstrated that hyperemia-induced changes in the Reflexion Index derived from the digital volume pulse are similar to those observed after albuterol-challenge and both are correlated.

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Published
2019-03-09
How to Cite
Wykretowicz, A., Adamska, K., Guzik, P., Zwanzig, M., Dziarmaga, M., & Krauze, T. (2019). Comparison of beta2-adrenergic and hyperemia-induced arterial vasodilation assessed by digital pulse contour analysis. Journal of Medical Science. https://doi.org/10.20883/jms.330
Section
Original Papers