Some nitroimidazole derivatives as antibacterial and antifungal agents in in vitro study

  • Justyna Żwawiak
  • Dorota Olender
  • Lucjusz Zaprutko
Keywords: nitroimidazoles, nitroimidazooxazoles, nitroimidazotetrahydropyrimidines, M. tuberculosis, antifungals

Abstract

Nitroimidazoles have wide range of therapeutic uses mainly as anaerobic antibacterials and antiprotozoal agents. Some bicyclic nitroimidazodihydrooxazoles and nitroimidazotetrahydrooxazines are found to be antituberculosis agents. Hence, the biological and chemical properties of mentioned substances are of great interest to scientists. The aim of this review is to show our contribution to general knowledge concerning the chemistry and biological activity of some nitroimidazole derivatives, based on experimental studies. Our results of biological tests provide many useful information on the effects of particular groups or other structural elements on the level of pharmacological activity. Also, these studies can be helpful in further planning of syntheses of active substances with using nitroimidazole moiety.
Published
2019-04-03
How to Cite
Żwawiak, J., Olender, D., & Zaprutko, L. (2019). Some nitroimidazole derivatives as antibacterial and antifungal agents in in vitro study. Journal of Medical Science. https://doi.org/10.20883/jms.218
Section
Review Papers