Current directions in searching for tuberculostatic substances

Authors

  • Justyna Żwawiak Department of Organic Chemistry, Poznan University of Medical Sciences, Poland
  • Lucjusz Zaprutko Department of Organic Chemistry, Poznan University of Medical Sciences, Poland

DOI:

https://doi.org/10.20883/medical.e58

Keywords:

tuberculosis, tuberculostatic agents, clinical trials

Abstract

Yearly, 8 milion people advance to active tuberculosis (TB) and nearly 2 milion victims die of their infection. Long drug regimen is blamed for the emergence of drug resistant TB. Moreover, 20% of TB isolates are already resistant to the first line antituberculosis drugs. This situation has required to develop new, more active anti-TB substances. Several novel drug candidates from different groups of chemical compounds undergo clinical trials. Others, also promising agents, have been obtained recently. They are the basis for further modifications heading for improvement of their physicochemical, biological and toxicological parameters.

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Published

2014-06-30

How to Cite

1.
Żwawiak J, Zaprutko L. Current directions in searching for tuberculostatic substances. JMS [Internet]. 2014 Jun. 30 [cited 2024 Apr. 26];83(2):138-44. Available from: https://jms.ump.edu.pl/index.php/JMS/article/view/58

Issue

Section

Review Papers
Received 2016-02-17
Published 2014-06-30